Moqapi oa Nicotinamide Riboside Chloride (NR) (23111-00-4) Moqapi - Cofttek

Nicotinamide Riboside chloride (NR) (23111-00-4)

April 7, 2020

Nicotinamide riboside, eo hape e tsejoang e le NR le SRT647, ke mofuta oa pyridine-nucleoside oa vithamine B3 o sebetsang e le selelekela sa nicotinamide adenine dinucleotide kapa NAD +. NR e thibela ho senyeha ha methapo ea methapo ea methapo e holofalitsoeng ka matla le ka tšireletso khahlanong le tahlehelo ea kutlo e bakiloeng ke lerata litoeba tse phelang.

 


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 1kg / mokotla, 25kg / Drum

 

Nikotinamide Riboside Chloride (NR) (23111-00-4) video

 

Nicotinamide Riboside chloride (NR) Slitšobotsi

Name: Nicotinamide Riboside chloride (NR)
CAS: 23111-00-4
Ho hloeka 98%
Limolek'hule Mokgwa wa ho Nahana: C11H15ClN2O5
Boima ba limolek'hule: 290.7 g / mol
Melt Point: 115-125 ° C
Lebitso la k'hemik'hale 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
Li-synonyms: Nikotinamide riboside; SRT647; SRT-647; SRT 647; Nikotinamide Riboside Triflate, motsoako oa α / β
InChI Key: YABIFCKURFRPPO-FSDYPCQHSA-N
Halofo ea bophelo: dihora tse 2.7
Solubility: Soluble ho DMSO, Methanol, Metsi
Boemo ba ho Boloka: 0 - 4 C bakeng sa nako e khuts'oane (matsatsi ho isa ho libeke), kapa -20 C nako e telele (likhoeli)
e sebetsa joang: Nicotinamide riboside e boleloa e le mofuta o mocha oa pyridine-nucleoside ea vithamine B₃ e sebetsang e le setsi sa pele sa nicotinamide adenine dinucleotide kapa NAD +.
Ponahalo: Off White ho Palela phofo

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4?

Nicotinamide riboside, eo hape e tsejoang e le NR le SRT647, ke mofuta oa pyridine-nucleoside oa vithamine B3 o sebetsang e le selelekela sa nicotinamide adenine dinucleotide kapa NAD +. NR e thibela ho senyeha ha methapo ea methapo ea methapo e holofalitsoeng ka matla le ka tšireletso khahlanong le tahlehelo ea kutlo e bakiloeng ke lerata litoeba tse phelang. Nicotinamide riboside e thibela mesifa, neural le melanocyte stem cell senescence. Ho eketseha ho eketsehileng ha mesifa ho litoeba ho hlokometsoe kamora kalafo ka nicotinamide riboside, e lebisang mohopolong oa hore e ka ntlafatsa ho nchafala ha litho tse kang sebete, a liphio le pelo. Nicotinamide riboside e boetse e theola tsoekere ea mali le sebete se mafura ho li-prediabetesic le mefuta ea 2 lefu la tsoekere ha o ntse o thibela nts'etsopele ea lefu la tsoekere le amanang le lefu la tsoekere. Tlhokomeliso: chotide ea Nicotinamide Riboside ke motsoako oa α / β.

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 melemo

Li-nucleoside tsa Nikotinamide ke li-pele tsa nicotinamide adenine dinucleotide (NAD) mme li emela mohloli oa vithamine B3. Boithuto ba morao-rao bo bonts'itse hore ho nka boholo ba nicotinamide nucleoside ka tlhaho li teng lijong ho ka fana ka melemo ea bophelo bo botle. Mohlala, li-nucleoside tsa nicotinamide li kentsoe ts'ebetsong ho eketsa khatello ea methapo ea NAD le ho kenya maikutlo a insulin hammoho le ho matlafatsa ts'ebetso ea sirtuin. Bokhoni ba eona ba ho eketsa tlhahiso ea NAD bo bontša hore li-nicotinamide nucleosides le tsona li ka ntlafatsa bophelo ba mitochondrial, tsa khothaletsa ts'ebetso ea mitochondrial, le ho kenya letsoho tlhahiso ea mitochondria e ncha. Boithuto bo bong bo sebelisang nicotinamide li-nucleoside mohlaleng oa lefu la Alzheimer bo bontšitse hore molek'hule e fumanehile ka bokong mme e ka fana ka neuroprotection ka ho tsosetsa motsoako oa boko ba NAD.

Nicotinamide Riboside Chloride le eona e ka fokotsa boima ba 'mele: Liphuputso li bonts'itse hore ka ho eketsa matla a metabolism, o ka fokotsa ka nepo phepo e nang le mafura a mangata e bakang boima ba' mele. Bakeng sa ho lekola mochini oa nicotinamide ribose oa NR o khothalletsang tahlehelo ea boima ba 'mele, bafuputsi ba ile ba lekanya ts'ebetso ea mitochondrial ea sebete e amanang le khalori e kenang, ts'ebetso, likhalori, selikalikoe sa letheka, phomolo ea sekhahla sa ts'oaetso,' mele, mamello ea tsoekere, kutlo ea insulin le likhemik'hale le metabolism mekhahlelo. Lintlha tsena le mochini o mocha oa ho theola boima ba 'mele ka malabsorption, excretion of marker marker for tracking. Bafuputsi ba tlaleha hore litoeba tse fepang nicotinamide nicotinamide li-supplements li na le monyetla oa ho theola boima ba 'mele ha li bapisoa le litoeba tse sa tlatselletseng nicotinamide

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 Mokhoa oa ts'ebetso?

Nicotinamide Riboside Chloride (NR) li-nucleoside ke li-precursors tsa nicotinamide adenine dinucleotide (NAD) mme li emela mohloli oa vithamine B3. Liphuputso tsa morao-rao li bontšitse hore ho nka nicotinamide nucleosides e ngata ka tlhaho e teng lijong ho ka fana ka melemo e mecha ea bophelo bo botle. Mohlala, li-nucleoside tsa nicotinamide li kentsoe letsoho ho eketsa mahlatsipa a NAD le ho baka ts'oaetso ea insulin le ho matlafatsa ts'ebetso ea sirtuin. Bokhoni ba eona ba ho eketsa tlhahiso ea NAD bo fana ka maikutlo a hore nicotinamide nucleosides le eona e ka ntlafatsa bophelo bo botle ba mitochondrial, ea matlafatsa ts'ebetso ea mitochondrial, mme ea hlohlelletsa tlhahiso ea mitochondria e ncha. Boithuto bo bong bo sebelisang nicotinamide nucleosides ka mofuta oa lefu la Alzheimer bo bontšitse hore molek'hule ha e fumanehe bokong mme e ka fana ka ts'ireletso ea methapo ka ho hlasimolla mohopolo oa NAD.

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 kopo

Liphuputso tse entsoeng esale pele li bontšitse hore ho eketsoa ha leqhubu la nicotinamide ho ke ke ha eketsa maemo a NAD + feela ka polokeho, empa hape ho ntlafatsa ts'ebeliso ea NAD + ho batho, ho sa khoneheng ka vithamine B3.Studies e 'ngoe e bonts'itseng hore hang nicotinamide ribose e hlaha seleng, mmele o e fetola ka potlako NAD +. Tsena NAD + joale li hlohlelletsa mokhoa oa ho qala ho kenella ha tlhahiso ea matla ka mitochondria

Nicotinamide Riboside Chloride e ka ntlafatsa ts'ebetso ea mitochondrial, e bonts'itsoeng ho ntlafatsa polelo ea liprotheine tsa li-protein tsa lipapatso tsa mitochondrial, ho ntlafatsa bokhoni ba mitochondrial membrane, le ho eketsa sekhahla sa ho phefumoloha ha oxidative le maemo a intracellular ATP. Sena se ka tsamaisana le maemo a phahameng a ntlafatso ea mitochondrial. Ts'ebetso ea Mitochondrial ea fokotseha ha re ntse re tsofala, 'me sena ke sesupo sa botsofe ba lisele tsa stem tseo re li fumanang. NR e ka ntlafatsa ts'ebetso ea mitochondria le ho thibela senescence ea lisele tsa stem.

 

Nicotinamide Riboside chloride (NR) phofo Ho rekisoa(U ka reka phofo ea Nicotinamide Riboside Chloride (NR) ka bongata)

Khamphani ea rona e thabela likamano tsa nako e telele le bareki ba rona hobane re tsepamisa maikutlo mosebetsing oa bareki le ho fana ka lihlahisoa tse ntle. Haeba o rata sehlahisoa sa rona, re feto-fetoha le maemo ka mokhoa oo re ratang ho odara ka oona o lekanang tlhoko ea hau le nako ea hau ea kapele ea li-odara e tiisa hore o tla latsoa sehlahisoa sa rona ka nako. Re shebile hape le lits'ebeletso tse kenyellelitsoeng boleng. Re fumaneha bakeng sa lipotso tsa ts'ebeletso le tlhaiso-leseling ho ts'ehetsa khoebo ea hau.

 

Re morekisi oa phofo ea Nikotinamide Riboside Chloride (NR) ka lilemo tse ngata, re fana ka lihlahisoa ka theko ea tlholisano, 'me sehlahisoa sa rona ke sa boleng bo holimo ebile sea hlahlojoa ka thata, se ikemetseng ho netefatsa hore se bolokehile bakeng sa ts'ebeliso lefatšeng ka bophara.

 

References

  • Chi Y, Sauve AA. Nicotinamide riboside, motsoako o fumanehang lijong, ke vithamine B3 e nang le litlamorao ho metabolism ea matla le neuroprotection. Curr Opin Clin Nutr Metab Tlhokomelo. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Tlhahlobo. PubMed PMID: 24071780.
  • Bogan KL, Brenner C. Nicotinic acid, nicotinamide, le nicotinamide riboside: tlhahlobo ea limolek'hule ea li-vithamine tsa NAD + tse tlang pele ho phepo ea batho. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Tlhahlobo. PubMed PMID: 18429699.
  • Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation e le moqapi oa methapo, mokoetlisi oa phetoho ea polokelo ea mafura: logic ea lik'hemik'hale le metabolic ea liphetoho tsa acetyl-lysine. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. Doi: 10.3109 / 10409238.2013.838204. Tlhahlobo. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.
  • Ntho e 'ngoe le e' ngoe eo u hlokang ho e tseba ka Nicotinamide Riboside Chloride