Video ea NR phofo (23111-00-4)
Nicotinamide Riboside chloride (NR) Slitšobotsi
| Name: | Nicotinamide Riboside chloride (NR) |
| CAS: | 23111-00-4 |
| Ho hloeka | 98% |
| Limolek'hule Mokgwa wa ho Nahana: | C11H15ClN2O5 |
| Boima ba limolek'hule: | 290.7 g / mol |
| Melt Point: | 115-125 ° C |
| Lebitso la k'hemik'hale | 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride |
| Li-synonyms: | Nikotinamide riboside; SRT647; SRT-647; SRT 647; Nikotinamide Riboside Triflate, motsoako oa α / β |
| InChI Key: | YABIFCKURFRPPO-FSDYPCQHSA-N |
| Halofo ea bophelo: | dihora tse 2.7 |
| Solubility: | Soluble ho DMSO, Methanol, Metsi |
| Boemo ba ho Boloka: | 0 - 4 C bakeng sa nako e khuts'oane (matsatsi ho isa ho libeke), kapa -20 C nako e telele (likhoeli) |
| e sebetsa joang: | Nicotinamide riboside e boleloa e le mofuta o mocha oa pyridine-nucleoside ea vithamine B₃ e sebetsang e le setsi sa pele sa nicotinamide adenine dinucleotide kapa NAD +. |
| Ponahalo: | Off White ho Palela phofo |
Nicotinamide Riboside chloride
'Mele oa motho ke sebopeho se rarahaneng se entsoeng ka lisele, lisele le litsamaiso tsa litho. Ts'ebetso e nepahetseng ea lisele le lisele tsa 'mele e laoloa le ho thusoa ke lik'hemik'hale tse fapaneng, li-enzyme le limatlafatsi. Tse ling tsa tsona 'mele o ka iketsetsa tsona,' me tse ling li tlameha ho jeoa. Kahoo, limatlafatsi tsena li ka sebopeho sa lijo le litlatsetso. E 'ngoe ea likarolo tsena tse ka thusang ho folisa le ho laola' mele e bitsoa nicotinamide riboside chloride (NR). E thusa ho eketsa palo ea nicotinamide adenine dinucleotide (NAD +) 'meleng.
Nicotinamide Riboside chloride e etsa eng?
Nicotinamide Riboside Chloride, eo hape e bitsoang NR, ke pyridine nucleoside ea vithamine B3. E sebetsa e le selelekela sa nicotinamide adenine dinucleotide (NAD +). E fumaneha e le 'mala o soeufetseng ho isa ho' mala o mosehla o sootho. Ke e 'ngoe ea li-precursors tsa NAD + tse ithutoang haholo kaha e na le melemo e mengata ea bophelo bo botle.
NAD + e amahanngoa le e le e 'ngoe ea likarolo tsa mantlha tse sebetsang mekhoeng e fapaneng ea homeostasis' meleng. E ka thusa ho boloka 'mele o phetse hantle, ea eketsa nako ea bophelo ea lisele, ea thusa ho etsa mesebetsi e fapaneng ea ts'ebetsong le ho thusa ho phekola mafu a fapaneng' meleng.
NR phofo e bontšitse katleho e le phekolo e ntseng e phahama maloetseng a fapaneng. Ka tekanyetso e phahameng, NR e ka alafa maemo a joalo ka mafu a pelo, methapo ea mafu, masapo a mesifa le mathata a ts'oaetso. NR e boetse e bontšitsoe e liehisa botsofali ba lisele le ho lelefatsa bophelo ba tsona. E fumanoa lihlahisoa tsa lijo tse kang litlhapi, likhoho, mahe, lebese le lijo-thollo.
Nicotinamide Riboside chloride e etsa eng?
Ho utloisisa seo nicotinamide riboside chloride e se etsang, re tlameha ho utloisisa pele nicotinamide adenine dinucleotide kapa NAD +.
NAD + ke coenzyme ea bohlokoa 'meleng oa motho. E sebetsa ho tsamaiseng litsela tse fapaneng tsa metabolic. Boteng ba eona 'meleng boa hlokahala bakeng sa ho phekola mefuta e mengata ea mafu. E boetse e thusa ho hlahisa matla bakeng sa boko, lisele tsa 'mele le mesifa.
Palo ea NAD + e ka fumanoang mehloling ea phepo e nyane haholo. Sena ha se lekane hore lisele tse ngata tsa 'mele li li sebelise. Kahoo ho e etsa, 'mele o feta litselaneng tse fapaneng. Ho na le litsela tse tharo tse kholo tseo NAD + e ka hlophisoang ka tsona. Tsela ea synthesis ea De novo, tsela ea Preiss Handler, le tsela ea Salvage.
Tsela ea Salvage ke ts'ebetso e tloaelehileng haholo eo NAD + e entsoeng ka eona 'meleng. Tseleng ena, NAD + e feta liphetohong tsa redox. E kenyelletsa ho fokotsoa ke li-elektronike tse tšoanang le tse ling, ebe li fetoha sebopeho se bitsoang nicotinamide adenine dinucleotide (NADH). Kaha tlatsetso ea lijo ha ea lekana bakeng sa tlhoko ea 'mele ea NAD +, tsela ea salvage e sebelisa le ho sebelisa NAD + e seng e ntse e le teng le mefuta ea eona e fapaneng.
E 'ngoe ea liketso tsa mantlha tseo NAD + e li etsang ke ho kenya tšebetsong li-sirtuin, sehlopha sa li-enzyme tse 7, Sirt1 ho Sirt7. Li-enzyme tsena li na le tšebetso ea ho laola botsofali le bolelele ba lisele. Li-sirtuin li sebetsa lits'ebetsong tse ngata tsa ts'ebetsong, joalo ka ho lokolloa ha insulin, ho hlohlelletsa lipids le karabelo ea khatello ea maikutlo. E ka ba ea laola nako ea bophelo. Li-sirtuin lia kenngwa tšebetsong ha maemo a NAD + a phahama.
NAD + hape ke substrate bakeng sa sehlopha sa liprotheine tse bitsoang poly ADP-ribose polymerase (PARP). E ikarabella bakeng sa tokiso ea DNA le botsitso liphatseng tsa lefutso mme e kanna ea ba le boikarabello ba nako e telele ea bophelo.
NAD + maemo a fokotseha ka lilemo le maloetse. A mang a mabaka a ho fokotseha ha ona ke ho ruruha ho sa foleng, ho eketsa ts'ebetso ea sesole sa 'mele, le ho fokotsa ts'ebetso ea nicotinamide phosphoribosyltransferase (NAMPT), e lebisang ho tlhahiso ea eona e fokotsehileng. Ha 'mele oa motho o ntse o tsofala, sekhahla sa tšenyo ea DNA sea eketseha ka menyetla e fokolang ea ho e lokisa, e baka botsofali le mofetše.
Ho na le mekhoa e 'maloa ea ho eketsa maemo a NAD +' meleng. Ba ja hanyane mme ba laola palo ea likhalori, ho itima lijo le ho ikoetlisa. Mesebetsi ena e ka thusa ho boloka 'mele o phetse hantle hape o le mafolofolo.
Mekhoa e meng ea ho eketsa NAD + e kenyelletsa ho ja tryptophan le niacin le ho nka NAD + boosters joalo ka nicotinamide riboside chloride le nicotinamide mononucleotide.
Nicotinamide riboside chloride ke selelekela se ka eketsang maemo a lisele tsa NAD +. Hape ke mohloli oa vithamine B3. Ke sehlahisoa se sebetsang tseleng ea poloko ea tlhahiso ea NAD +. E fetoha nicotinamide mononucleotide (NMN) ka thuso ea enzyme NR kinase Nrk1. E tsoela pele ho fetoha NAD +.
Kamora ho fana ka NR, litekanyetso tsa NAD + lia eketseha 'meleng, ebe li abeloa likarolo tse fapaneng. Ha e khone ho tšela mokoallo oa mali le boko, empa e fetoha nicotinamide e ntan'o isoa bokong le liseleng tse ling moo e etsang NAD +.
Boholo ba tlhaiso-leseling e mabapi le katleho ea Nicotinamide Riboside chloride e tsoa lipatlisisong tsa liphoofolo. Liphuputso tse entsoeng ke batho li ntse li lekantsoe mme li hlokahala haholo.
Melemo ea Nicotinamide Riboside Chloride
Ho na le melemo e 'maloa ea ho sebelisa Nicotinamide Riboside Chloride. Ke:
Phello ho Mafu a Neuromuscular
Bokhoni ba Nicotinamide riboside chloride ba ho eketsa NAD + bo ka ntlafatsa mesebetsi ea mitochondria. Sena se ka thusa ho phekola myopathies ea mitochondrial [1]. NR phofo e boetse e bontšitsoe e sebetsa hantle ho ntlafatsa mesebetsi ea mesifa ea mesifa.
Liphello tsa mafu a pelo
Mathata afe kapa afe ka metabolism ea NAD + a ka baka mathata ka pelo le methapo ea mali. E ka baka maemo a joalo ka ho hloleha ha pelo, khatello ea khatello ea maikutlo, infarction ea myocardial, jj NR supplementation e ka tlisa karolelano ea NAD + le nicotinamide adenine dinucleotide + hydrogen (NADH) ho tloaelehileng le ho emisa ho lokisoa hampe ha lisele tsa pelo [2]. E ka fetola le litlamorao tsa ho hloleha ha pelo.
Liphello ho mafu a neurodegenerative
Hangata mafu a Neurodegenerative a etsahala ka botsofali. Li amahanngoa le khatello ea mali e ka bakang tšenyo ho DNA. Hangata, ho tla ba le liketso tse sa tloaelehang tsa mitochondria, kamora lintlha tse ling kamora moo lisele li ke keng tsa sebetsa hantle. NAD + e fokotseha ka bongata ha mmele o ntse o tsofala, o lebisang ts'ebetsong e fosahetseng ea mitochondria. Sena se ka baka mafu a fapaneng a methapo ea kutlo. E ka eketsa menyetla ea lefu la Alzheimer.
Nicotinamide Riboside chloride e eketsa palo ea NAD + 'meleng, e fokotsa khatello ea mali, hape e ka lokisa DNA e senyehileng. Ho boetse hoa thusa ho phekola lefu la Alzheimer ho litoeba [3]. E ka boela ea fokotsa ho ruruha bokong, ho thusa ho ntlafatsa ts'oaetso le mohopolo [4]. E ka etsa sena ka ho fokotsa palo ea protheine ea selelekela sa amyloid-and le ho thibela amyloidogenesis.
NR phofo e ka boela ea emisa ho senyeha ha li-axon ka mefuta e sa foleng ea maloetse a nang le tšoaetso ea methapo ka ho fetola metabolism ea NR ka axon [5]. Ho senyeha ha methapo ea kutlo ea `` ganglion neurons '' e sa hlokeng lisele tsa moriri tse kopaneng e ka etsahala kamora ho pepesetsoa ke lerata le feteletseng. NR e bontšitse e sebetsa hantle ho thibela tahlehelo ea kutlo e bakoang ke lerata. E etsa sena ka ho sebetsa ka sirtuin kapa SIRT3-e itšetlehileng ka mochini o fokotsang ho senyeha ha methapo ea kutlo [6].
Phello ho batho ba nang le lefu la tsoekere
Nicotinamide ribonucleoside chloride e bonts'itse hore e sebetsa hantle ho fokotsa matšoao a ts'oaetso ea ts'oaetso joaloka lefu la tsoekere la Type II [7]. E bonts'itsoe e ntlafatsa mamello ea tsoekere, ea fokotsa boima ba 'mele le ea ho senya sebete ho litoeba. Kahoo e kanna ea atleha ho phekoleng batho le bona.
Phello bophelong ba sebete
Maemo a sebete a joalo ka lefu la sebete le mafura le senang joala a bontšitsoe a baka khaello ea NAD +. Kahoo, ho tlatselletsa ka phofo ea NR ho ka thusa ho hlaphoheloa hamolemo maemong ana [8].
Phello ea ho tsofala
NAD + e boetse e fumanoe e fokotsa botsofali ba lisele le ho li nchafatsa. Ho fumanoe hape hore e ntlafatsa mesebetsi ea stem cell e thusang ho fokotsa botsofali [9].
Molemo oa Nicotinamide Riboside Chloride Ho feta tse ling tsa li-precurs tsa NAD
NR e na le bioavailability e ntle ebile e sireletsehile ho e sebelisa ha e bapisoa le tse ling tse tlileng pele ho eona. Ho bonts'itsoe ho eketsa maemo a NAD + ho feta ka ho noa ka molomo ho litoeba hape ho fana ka NAD + e eketsehileng mesifa ha e bapisoa le tse ling tsa pele. E ka boela ea laola maemo a lipid tsa mali hantle le ho eketsa boemo ba NAD + ka pelong [10].
Litla-morao tsa Nicotinamide Riboside Chloride
Ho ja molomo oa nicotinamide riboside chloride ka tekanyetso e tlase ho batla ho bolokehile. E ka kenyelletsa litla-morao tse ling joalo ka
- Nausea
- Ho thibela
- Edema
- Ho hlatsoa
- Mokhathala
- Moriri oa hlooho
- Letšollo
- Ho otloa ke mpa
- Boitšoaro
- Ho otla
U ka reka Nicotinamide Riboside Chloride joang?
Haeba u batla ho reka phofo ea NR, ho molemo ho ikopanya ka kotloloho le fektheri ea moetsi oa Nicotinamide Riboside Chloride. E netefatsa hore thepa ea boleng bo holimo e sebelisoa bakeng sa tlhahiso, ka leihlo la mahlo la litsebi lefapheng le amanang. Lihlahisoa tsena li etsoa ho latela litataiso tse thata tsa polokeho tse netefatsang hore sehlahisoa ke sa boleng bo holimo, se na le matla a maholo, 'me se pakiloe hantle. Ho latela tlhoko ea mosebelisi, liodara li ka etsoa hore li lumellane le tatso ea tsona.
Hang ha sehlahisoa se entsoe, se hloka ho bolokoa mocheso o batang oa 0 ho isa ho 4C bakeng sa nako e khuts'oane le -20C nako e telele. Ke ho e thibela hore e senyehe kapa e sebetse ka lik'hemik'hale tse ling tikolohong.
References
- Chi Y, Sauve AA. Nicotinamide riboside, motsoako o fumanehang lijong, ke vithamine B3 e nang le litlamorao ho metabolism ea matla le neuroprotection. Curr Opin Clin Nutr Metab Tlhokomelo. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Tlhahlobo. PubMed PMID: 24071780.
- Bogan KL, Brenner C. Nicotinic acid, nicotinamide, le nicotinamide riboside: tlhahlobo ea limolek'hule ea li-vithamine tsa NAD + tse tlang pele ho phepo ea batho. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Tlhahlobo. PubMed PMID: 18429699.
- Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation e le moqapi oa methapo, mokoetlisi oa phetoho ea polokelo ea mafura: logic ea lik'hemik'hale le metabolic ea liphetoho tsa acetyl-lysine. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. Doi: 10.3109 / 10409238.2013.838204. Tlhahlobo. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.
- Ntho e 'ngoe le e' ngoe eo u hlokang ho e tseba ka Nicotinamide Riboside Chloride
