Urolithin phofo

Cofftek e na le bokhoni ba tlhahiso ea bongata le phepelo ea urolithin a, urolithin b le Methylurolithin A tlasa boemo ba cGMP.

Urolithins ke eng?

Li-Urolithin ke lihlahisoa kapa li-metabolite tsa likarolo tsa ellagic acid tse kang ellagitannins. Likarolo tsena tsa lik'hemik'hale li silafatsoa ke li-ellagic acid-derivatives ke gut microbiota.

Kaha limela tsa mala li bohlokoa bakeng sa tlhahiso ea li-urolithin, bongata ba li-urolithin tse hlahisoang 'meleng bo ipapisitse le mofuta oa limela tse limela, e leng setho sa bohlokoahali sa sehlopha sa Clostridium leptum. Ho tlalehoa hore batho ba nang le microbiota ba ruileng ho litho tsa sehlopha sena ba hlahisa palo e phahameng haholo ea li-urolithin ho feta tse nang le limela tse ling tsa mala tse kang Bacteroides kapa Prevotella.

Li-Urolithin le tsona li hlahisoa ka punicalagin ka maleng, hantle joalo ka li-ellagitannins, ebe li ntšetsoa ka ntle ho moroto. Ho lekola tlhahiso ea urolithin 'meleng, maemo a bona a hloka ho hlahlojoa morotong oa motho ea jeleng lijo tse nang le asiti e ellagic kapa tse tlatselletsang ka li-urolithin e le sesebelisoa sa bona sa mantlha. Urolithin, hang ka lero la mali, e ka fumanoa ka mofuta oa glucuronides.

Li-Urolithin li fumaneha ka tlhaho lijong tse 'maloa, leha e se limolek'hule tsohle tsa urolithin tse ka tsoang lijong. Hang ha lijo tse nang le asiti e ellagic li kentsoe, ho latela limela tsa mala ho senya li-ellagitannins le punicalagin ho ea pele ho li-metabolite tse mahareng le lihlahisoa tsa ho qetela; limolek'hule tsa urolithin.

Limolek'hule tsena haufinyane li fumane botumo mme li ntse li tsoela pele ho phahama e le li-supplement tsa lijo tse phahameng ka lebaka la lithibela-mafu, anti-botsofali, anti-inflammatory, le melemo ea ho its'oarella. Ho feta moo, limolek'hule tse khethehileng tsa urolithin li amahanngoa le maemo a ntlafetseng a matla kaha li na le tšusumetso e kholo ho bophelo bo botle ba mitochondrial. Tlhahiso ea matla 'meleng ke ts'ebetso e etsahalang mitochondria, mme ho ntlafatsa ts'ebetso ea organelle ena ke o mong oa mesebetsi e mengata ea Urolithins.

Limolek'hule tse tsebahalang tsa Urolithin

Li-Urolithin li bua ka bongata ho limolek'hule tse fapaneng tsa lelapa la urolithin empa li na le mekhoa e fapaneng ea lik'hemik'hale, mabitso a IUPAC, likarolo tsa lik'hemik'hale le mehloli. Ho feta moo, limolek'hule tsena li na le ts'ebeliso le melemo e fapaneng haholo 'meleng oa motho ka hona li bapatsoa ka tsela e fapaneng ka mokhoa oa tlatsetso.

Li-Urolithin, kamora ho etsa lipatlisiso tse pharaletseng, li tsejoa ka hore li senyeha ka limolek'hule tse latelang 'meleng, leha ho sa tsejoe hakaalo ka molek'hule e ngoe le e ngoe e ikhethang.

● Urolithin A (3,8-Dihydroxy Urolithin)
● Urolithin A glucuronide
● Urolithin B (3-Hydroxy Urolithin)
● Urolithin B glucuronide
● Urolithin D (3,4,8,9-Tetrahydroxy Urolithin)

Urolithin A le Urolithin B, tse tsejoang ka ho fetisisa e le UroA le UroB ka ho latellana, ke li-metabolite tse tsebahalang tsa Urolithins 'meleng. Tsena tse peli hape ke limolek'hule tse ntseng li sebelisoa hajoale ho li-supplement le li-powders tse ncha tsa lijo.

Hang ha e le maling, Urolithin A e ba teng ha Urolithin A glucuronide, mme Urolithin B e ka fumanoa e le Urolithin B glucuronide. Ka lebaka la sena, ho lumeloa hore li na le litlamorao tse tšoanang le tsa ba tlileng pele ho bona joalo ka ha liphuputso tsa vivo li sa khonehe ka li-urolithin. Ho haella ha lithuto tsa vivo ho etsa hore ho be thata ho lekola hore na UroA le UroB glucuronides li na le litlamorao tse fapaneng le UroA le UroB ka botsona.

Urolithin A e na le sehlahisoa se seng se ka fumanoang maling, e leng, Urolithin A sulfate. Lihlahisoa tsena tsohle li etsa mesebetsi ea tsona maling ebe li hlakoloa tsamaisong ka moroto.

Urolithin D ke molek'hule e 'ngoe ea bohlokoa e hlahisoang ke litlamorao tsa gut microbiota, leha ho le joalo, ha ho tsejoehale haholo ka litlamorao le ts'ebeliso e ka bang teng ea eona. Hajoale, ha e sebelisoe litlatselisong kapa phetisetsong ea lijo, ho fapana le balekane ba eona, UroA le UroB. Ho feta moo, mehloli ea lijo tsa Urolithin D ha e tsejoe.

Sephutheloana sa Boitsebiso ba Urolithin A Powder

Urolithin A ha e fumanehe ka tlhaho ho tsoa mehloling ea lijo ebile ke ea sehlopha sa metsoako e tsejoang ka hore ke benzo-coumarins kapa dibenzo-α-pyrones. Ha e le hantle e kopantsoe le li-ellagitannins ho ea ho Urolithin A 8-Methyl Ether pele e ka senyeha hape hore e be Urolithin A. Sehlahisoa sena sa ho qetela se fumaneha ka bongata fekthering ea rona ea tlhahiso ka mofuta oa Urolithin A phofo. MethylUrolithin A phofo e fumaneha hape hore e rekoe ka bongata ha ho hlokahala.

Urolithin A ha e fumanehe maemong a ts'oanang, leha ho na le maemo a ts'oanang a ts'ebeliso ea tse tlileng pele ho eona, ho batho ba fapaneng hobane e its'etleha holima tšebetso ea gut microbiota. Metabolism ea Urolithin A ho lumeloa hore e hloka Gordonibacter urolithinfaciens le Gordonibacter pamelaeae empa batho ba bang ba nang le tsona ba ntse ba bontša ho honyenyane ho sa ame letho tlhahisong ea molek'hule.

Urolithin A e na le likarolo tse ikhethang tse etsang hore e hlahelle ho likarolo tse ling, joalo ka tse boletsoeng tafoleng e ka tlase.

Nomoro ea CAS1143-70-0
Ho hloeka98%
Lebitso la IUPAC3,8-Dihydroxybenzo [c] chromen-6-ngoe
Li-synonyms3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-ngoe; 3,8-DIHYDRO DIBENZO- (B, D) PYRAN-6-ONE; 3, 8-Dihydroxy-6H-benzo [c] chromen-6-e le 'ngoe; Pente ea Castoreum I; Urolithin A; 6H-Dibenzo (B, D) pyran-6-ngoe, 3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-ngoe); urolithin-A (UA; 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-ngoe
Molecular FormulaC13H8O4
Boima ba 'mele228.2
Melting Point> 300 ° C
InChI KeyRIUPDUFZCXCHM-UHFFFAOYSA-N
foromotiileng
PonahaloPhofo e khanyang e khanyang
Halofo ea bopheloHa e tsejoe
SolubilitySoluble ho DMSO (3 mg / mL).
Boemo StorageMatsatsi ho isa ho Libeke: Ka kamoreng e lefifi, e omileng ka 0 - 4 likhato tsa C Likhoeli ho isa ho Lilemo: Ka Freezer, hole le lino tse ka bang -20 likhato tsa C.
kopoLisebelisoa tsa lijo e le phetoho ea lijo le li-supplement

Sephutheloana sa Boitsebiso ba Urolithin B Powder

Urolithin B ke motsoako oa phenolic o qalileng ho hlahisoa ka bongata ho tloha ka Pherekhong oa 2021. E ka fumanoa ka ho ja lijo tse 'maloa tseo e leng mehloli ea tlhaho ea li-ellagitannins tse ka sebelisoang ho Urolithin B. E fumanoe e le matla komponeng e thibelang botsofali eo u ka e rekang ka bongata ka mofuta oa phofo ea Urolithin B.

Thepa e fapaneng ea phofo ea Urolithin B e fumanehang k'hamphaning ea rona ea tlhahiso e boletsoe ka tlase:

Nomoro ea CAS1139-83-9
Ho hloeka98%
Lebitso la IUPAC3-Hydroxy-6H-dibenzo [b, d] pyran-6-ngoe
Li-synonymsAURORA 226; Urolithin B; AKOS BBS-00008028; 3-hydroxy urolithin; 3-hydroxy-6-benzo [c] chromenone; 3-hydroxybenzo [c] chromen-6-ngoe; 3-Hydroxy-benzo [c] chromen-6-e le 'ngoe; 3-HYDROXY-6H-DIBENZO [B, D] PYRAN-6-ONE; 6H-Dibenzo (b, d) pyran-6-one, 3-hydroxy-; 3-Hydroxy-6H-benzo [c] chromen-6-ngoe AldrichCPR
Molecular FormulaC13H8O3
Boima ba 'mele212.2 g / mol
Melting Point> 247 ° C
InChI KeyWXUQMTRHPNOXBV-UHFFFAOYSA-N
foromotiileng
PonahaloPhofo e sootho e bobebe
Halofo ea bopheloHa e tsejoe
SolubilityQhibiliha ka 5mg / mL ha ho futhumala, metsi a hlakileng
Boemo Storage2-8 ° C
kopoAnti-oxidant le Pro-oxidant tlatsetso le ts'ebetso ea estrogenic.


Ntle le limolek'hule tsena tsa mantlha tsa Urolithin tse entsoeng ka lebaka la liketso tsa limela tsa mala, ho na le limolek'hule tse 'maloa tse kopaneng nakong ea ho senyeha ha li-precursors. Li-intermediates tsena li kenyelletsa:

● Urolithin M-5
● Urolithin M-6
● Urolithin M-7
● Urolithin C (3,8,9-Trihydroxy urolithin)
● Urolithin E (2,3,8,10-Tetrahydroxy urolithin)

Ha ho tsejoe hakaalo ka li-intermediate ho tloha joale, leha ho le joalo, lipatlisiso tse ling li na le monyetla oa ho fumana melemo le ts'ebeliso ea limolek'hule tsena tsa Urolithin.

Urolithins e sebetsa joang?

Li-Urolithin, joalo ka metsoako e meng e sebelisitsoeng ho tlatseng, e ama litho le litsamaiso tse fapaneng 'meleng, ho hlahisa litholoana tse ntle. Mechini e sebetsang ea Urolithins, ka bobeli A le B, e ka aroloa ka makala a maholo a tšeletseng, mme lekala ka leng le na le monyetla oa ho hlahisa melemo e mengata.

● Thepa ea antioxidant
Molemo o ka sehloohong oa ho ba le thepa ea antioxidant o fokotse khatello ea maikutlo 'meleng. Ho imeloa kelellong ho bolela khatello ea maikutlo ea lisele le lisele tsa 'mele ka lebaka la liphetoho tsa lik'hemik'hale tse hlahisang metsoako e sa tsitsang, e tsejoang hape e le li-radicals tsa mahala. Li-radical tsena tsa mahala li na le menyetla e meng ea ho nka karolo liketsong tse sa fetoheng tsa lik'hemik'hale 'meleng, lihlahisoa tsa tsona tse senyang lisele le lisele.

Li-Urolithin li hatella khatello ea mali ena, e lebisang ho thibelo ea likotsi tsa sele le ho eketsa menyetla ea ho phela ha sele. Litholoana tsena li entsoe hore li khonehe ka ho fokotsa tlhahiso ea li-intracellular Reactive Oxygen Species (iROS), e leng mofuta oa li-radicals tsa mahala. Ho feta moo, li-antioxidant tsa Urolithin A le Urolithin B le tsona li hlaha ka ho fokotsa polelo ea NADPH oxidase subunit, e bohlokoa bakeng sa liphetoho tsa lik'hemik'hale tse bakang khatello ea mali.

Ho hlahisa thepa ea antioxidant, Urolithins le eona e eketsa polelo ea antioxidant heme oxygenase-1 ka tsela ea ho tšoaea ea Nrf2 / ARE. Sena ha se ba thuse feela ho fokotsa metsoako e kotsi empa se boetse se eketsa li-enzyme tse ntle tse khothalletsang thepa ea antioxidant.

Li-Urolithin, ha li fuoa litoeba tse nang le tšenyo ea boko bo bakoang ke LPS, li thibela ts'ebetso ea microglial, kapa ka mantsoe a bonolo, lebali le sebopeho sa ho ruruha tse ka eketsang kotsi ea ts'enyo e sa feleng ea boko. Phello ea li-urolithin ho lumeloa hore ke motsoako oa thepa ea antioxidant le e khahlanong le ho ruruha.

● Thepa ea ho ruruha e khahlanong le ho ruruha
Lintho tse khahlanong le ho ruruha tsa Urolithins ke le leng la mabaka a mantlha a botumo ba eona bo ntseng bo phahama lefatšeng la tlatsetso. Mochini oo metsoako ena, haholo-holo Urolithin A, Urolithin B, le sebopeho sa 'ona sa glucuronides, li fapaneng haholo' me li hlahisa litholoana tse fapaneng ka ho lekana.

Phello e khahlano le ho ruruha ea Urolithin A le Urolithin B e na le mochini o ts'oanang le oa li-anti-inflammatory tsa li-non-Steroidal kapa li-NSAID joalo ka Ibuprofen le Aspirin. Li-Urolithin li tsejoa hore li na le phello e thibelang tlhahiso ea PGE2 le polelo ea COX-2. Ha li-NSAID li thibela polelo ea bobeli ba COX 1 le COX 2, ho ka fihlela qeto ea hore li-Urolithin li na le tšusumetso e khahlano le ho ruruha.

Litšobotsi tse khahlano le ho ruruha tsa Urolithins ho netefalitsoe hore ha li loantše feela ho ruruha 'meleng empa hape li khona ho etsolla tšenyo e entsoeng lithong ka lebaka la ho ruruha ha nako e telele ho bakileng ho hloleha ha setho. Phuputsong ea haufinyane e entsoeng ka mefuta ea liphoofolo, ho fumanoe hore ts'ebeliso ea urolithin e na le bokhoni ba ho fokotsa nephrotoxicity e bakoang ke lithethefatsi ka ho thibela lefu la sele le renal le ho ruruha.

Ho fumanoe hore urolithin A phofo, e fanoeng ka molomo, e na le tšusumetso e thibelang tsela ea ho ruruha hammoho le proapoptotic cascade, ka hona, ho sireletsa ts'ebetso ea renal. Lintho tsena tsa Urolithin A hammoho le li-urolithin tse ling li supa bokamoso moo metsoako ena e ka sebelisoang e le moriana hammoho le ts'ebeliso ea hona joale e le litlatsetso.

● Thepa ea Anti-Carcinogenic
Ho lumeloa hore li-Urolithin li khahlanong le lefu la kankere ka lebaka la bokhoni ba tsona ba ho ba le litlamorao tse kang ho ts'oaroa ha lisele tsa sele, aromatase inhibition, ho kenella ha apoptosis, khatello ea hlahala, ho khothaletsa autophagy, le senescence, taolo ea sengoloa ea oncogenes, le li-receptor tsa kholo. Litlamorao tsena, haeba li le sieo, li ka baka kholo e mpe ea lisele tsa mofetše. Likarolo tse thibelang tsa Urolithins li netefalitsoe, haholoholo bakeng sa mofetše oa senya le mofetše oa colon, ka bafuputsi ba bangata ba ipokellela ts'ebeliso ea Urolithins e le meriana e ka thibelang mofetše oa senya.

Phuputso e entsoeng ka 2018 e ithutile litlamorao tsa Urolithin tseleng ea mTOR ka sepheo sa ho fumana khetho ea kalafo bakeng sa mofetše oa pancreatic. Kankere ea Pancreatic e amahanngoa le lipalo tse phahameng tsa batho ba shoang, empa lipatlisiso tsa morao-rao li bonts'a hore Urolithin e kanna ea se khone ho eketsa sekhahla sa pholoho feela empa e ka thibela ho hlomathisetswa ha lisele tsa hlahala likarolong tse ling tsa 'mele, ho baka metastasis. Urolithin A e ile ea ithutoa ka kotloloho mme liphetho tsa bapisoa le liphetho tse hlahisoang ke regimen ea kalafo e tloaelehileng. Ho phethetsoe hore Urolithin A e hlahisitse litholoana tse ntle ha e sebelisoa ho laola mofetše oa pancreatic, maemong ka bobeli; ha e sebelisoa e le mong kapa ka moralo o tloaelehileng oa kalafo.

Ka lipatlisiso tse ling, melemo ea Urothilins e kanna ea ba le kalafo ea mofetše oa pancreatic hape.

● Thepa ea Antibacteria
Li-Urolithin li tsejoa ka thepa ea tsona ea likokoana-hloko 'me li na le phello ena ka ho thibela metjha ea puisano ea likokoana-hloko, li sa li lumelle ho tsamaea kapa ho tšoaetsa lisele. Ho boetse ho lumeloa hore li na le thepa e loantšang fungal, leha ts'ebetso e nepahetseng e ntse e sa hlaka.

Ho na le likokoana-hloko tse peli tseo Urolithin e nang le tšusumetso e matla ho tsona, e lebisang ho ts'ireletso bakeng sa 'mele oa motho. Likokoana-hloko tsena ke likokoana-hloko tsa malaria le Yersinia enterocolitica, ka bobeli ba tsona li baka tšoaetso e matla bathong. Mochini oo Urolithin a nang le ona thepa ea antibacteria ho sa tsotelehe 'mele o ts'oanang.

● Thepa ea Anti Estrogenic le Estrogenic
Estrogen ke hormone ea bohlokoa 'meleng oa basali,' me ho theoha ha maemo a eona ho amahanngoa le matšoao a kang ho ruruha, ho chesa ho chesang le ho fokotsa masapo. Ka lebaka la bohlokoa ba hormone, hoa utloahala hore motho ea kenang o ntse a phenyekolloa ka mafolofolo. Leha ho le joalo, lihormone tse ikhethang li na le litla-morao tse itseng tse etsang hore ts'ebeliso ea tsona e se ratehe.

Leha ho le joalo, Urolithin A le Urolithin B li na le sebopeho se ts'oanang le estrogen e sa feleng le kamano ea li-receptor tsa estrogen 'meleng. Urolithin A e na le kamano e matla le ho feta, haholo bakeng sa receptor ea alpha ha e bapisoa le ea beta receptor. Le ha metsoako ena ka bobeli e tšoana ka sebopeho sa estrogen, li-urolithin li na le thepa ea estrogenic le anti-estrogenic, ho fapana le estrogen e sa feleng.

Boholo ba phello ena ea Urolithins bo ba etsa khetho ea kalafo bakeng sa mathata a itseng a hlahang ha estrogen e fanoang ho phekola matšoao a khaello ea estrogen.

● Ho thibela liprotheine Glycation
Protheine glycation ke mohato oo ho oona molek'hule ea tsoekere e tlangang ho protheine. Ts'ebetso ena e bonoa nakong ea botsofali kapa e le karolo ea mathata a itseng. Li-Urolithin li thibela ho eketsoa ha tsoekere, ka hona ho baka litlamorao tsa anti-glycation. Ho feta moo, li thibela tlhahiso ea lihlahisoa tse tsoetseng pele tsa glycation, eo ho bokellana ha eona e leng mohato oa bohlokoa oa ho holisa lefu la tsoekere.

Melemo ea Urolithins

Li-Urolithin li na le mekhoa e fapaneng ea ts'ebetso ho hlahisa melemo e fapaneng ea ts'ireletso 'meleng oa motho. Urolithin A phofo le phofo ea Urolithin B li thusa ho etsa li-supplement tse tsebahalang ka lebaka la melemo ea metsoako e meholo. Melemo eohle ea metsoako ena ea lik'hemik'hale e tšehelitsoe ke bopaki ba mahlale, mme ho ntse ho etsoa lipatlisiso tse ling ho ts'ehetsa ho eketsoa ha Urolithins tataisong ea kalafo ea mathata a 'maloa.

Melemo ea metsoako ena, e ipapisitse le mekhoa e boletsoeng kaholimo, e kenyelletsa:

● Thepa ea antioxidant
Li-Urolithin li ntšoa lijong tse 'maloa tse nang le li-ellagitannins tse tsejoang hore li na le li-antioxidants tse ngata. Mohloli o tloaelehileng haholo oa lijo tsa ellagitannins le ellagic acid ke likharenate, hape ke mohloli o moholo oa li-antioxidants. Leha ho le joalo, ho bohlokoa ho khetholla hore na li-antioxidant tsa mohloli oa lijo le li-urolithin lia tšoana kapa haeba e 'ngoe e na le bokhoni bo phahameng ho feta e' ngoe.

Boithuto ba pele ba Urolithin A le Urolithin B bo bonts'itse hore litlamorao tsa antioxidant tsa tsena li ne li le tlase ho makhetlo a 42 ho feta tholoana ka bo eona, ka hona ho bolela hore metsoako ena ea lik'hemik'hale e ke ke ea etsa metsoako e metle ea litlatsetso.

Leha ho le joalo, lithuto tsa morao-rao tse nang le mokhoa o fapaneng oa ho sekaseka li bonts'a hore Urolithin A le B li sebetsa hantle ebile li na le thepa e matla ea antioxidant e tla loants'a litlamorao tsa khatello ea mali. Ha mokhoa o ts'oanang oa tlhahlobo o ne o sebelisoa ho ithuta li-urolithin tsohle ho bona hore na ke efe e matla ka ho fetisisa, Urolithin A e ile ea hlahella. Liphetho li ile tsa hlahisoa thutong e ts'oanang le Urolithin A ea etelletseng pele ka potency, hape.

Ebile, e 'ngoe ea lithuto e shebile ho lekola likarolo tsa antioxidant tsa metsoako ena ea lik'hemik'hale ka ho lekola bokhoni ba tsona ba ho loants'a khatello ea mali. Bakeng sa boithuto bona, bafuputsi ba ile ba baka khatello ea maikutlo liseleng tsa neuronal mme ha ba pepesetsoa Urolithins, haholo-holo Urolithin B, ba hlokometse ho fokotseha ho totobetseng ha khatello ea maikutlo hammoho le pholoho e eketsehileng ea lisele tsa neuronal.

● Thepa ea ho ruruha e khahlanong le ho ruruha
Likokoana-hloko tse khahlanong le ho ruruha tsa Urolithins li hlahisa melemo e 'maloa, tseo kaofela li pakiloeng ka mahlale.

1.Antimalarial e le hantle
Pheko ea maiketsetso ea kalafo ea malaria e sebelisoang haholo libakeng tse ling tsa mahaeng e kenyelletsa tšebeliso ea kharenate. Bafuputsi ba lekile ho utloisisa litholoana tse ntle tsa pheko ena kalafong ea malaria ka ho amahanya sephetho le litlamorao tsa Urolithin tse silafalitsoeng ka mpeng ke kharenate.

Ho ile ha etsoa phuputso ho ithuta phello ea Urolithins ho phekoleng malaria ka ho pepesa lisele tsa monocytic tse nang le tšoaetso ho Urolithins. Phuputso ena e fumane hore metsoako ea lik'hemik'hale e thibela ho tsoa ha MMP-9, e leng metalloproteinase ea bohlokoa nts'etsopele le pathogenesis ea malaria. Thibelo ea komponeng e thibela malaria ho ba likokoana-hloko 'meleng, ke ka lebaka leo ho lumeloang hore e na le phello ea malaria.

Liphetho tsa phuputso li boetse li bonts'a hore Urolithins e thibetse polelo ea mRNA ea likokoana-hloko tsa malaria, e lebisang ho thibelo e tsoelang pele ea bokhoni ba likokoana-hloko ba ho baka tšoaetso. Liphetho tsa boithuto bona li paka hore melemo ea litlhare tse entsoeng ka maiketsetso ho kenyeletsoa le kharenate e bakoa ke litlamorao tsa urolithin.

Phello ea lisele tsa Endothelial
Atherosclerosis ke boemo bo tloaelehileng bo lebisang ho litlhapa tsa pelo le infarction ea myocardial. Lintho tse peli tse tloaelehileng tse bakang kholo ea atherosclerosis ke ho se sebetse ha endothelial le ho ruruha. Liphuputso tsa morao-rao li lekile ho paka hore thepa e khahlanong le ho ruruha ea Urolithin e kanna ea thibela ho se sebetse hoa endothelial, ka hona ea laola ho theoa le nts'etsopele ea atherosclerosis.

Urolithin A e fumanoe ke bafuputsi hore e na le ketso e phahameng ka ho fetisisa e khahlanong le ho ruruha har'a li-urolithin tsohle. Phuputso ea morao-rao e shebile lisele tsa motho tse qetellang li entsoe ka LDL e nang le oxidized, ntho e hlokahalang bakeng sa sebopeho sa atherosclerosis, le libaka tse fapaneng tsa Urolithin A. Bafuputsi ba fumane hore Urolithin A e thibetse nitric oxide synthase mme ea fokotsa polelo ea I-CAM, e bakileng hore fokotsa ho ruruha le ho fokotseha ha bokhoni ba lisele, haholo-holo monocyte ho khomarela lisele tsa endothelial, ka ho latellana. Ho fokotsa ho khomarela monocytic ho fokotsa ho se sebetse ha endothelial.

Ho feta moo, Urolithin A e fumanoe e fokotsa polelo ea hlahala necrosis factor α, interleukin 6, le endothelin 1; li-cytokine tsohle tse thibelang ho ruruha.

Phello ea li-Fibroblast Colon
Colon e pepesetsoa likokoana-hloko tse sa tloaelehang le likarolo tsa phepo e etsang hore e be tlokotsing ea ho ruruha, eo ha nako e ntse e ea e ka lebisang litabeng tse 'maloa tsa bophelo bo botle. Ha Urolithin A le Urolithin B li hlahisoa ke limela tsa mala, ho bohlokoa ho tseba litlamorao tsa tsona 'meleng oa tsona.

Ho ithuta litlamorao tsa li-Urolithin liseleng tsa colon le li-fibroblast, bafuputsi ba ile ba etsa liteko moo li-fibroblast li pepesitsoeng ke li-cytokine tse matlafatsang ebe li ea ho Urolithins. Joalokaha ho boletsoe kaholimo, ho fumanoe hore Urolithins e thibela ho khomarela monocyte le phallo ea fibroblast ho thibela ho ruruha kolone.

Ho feta moo, ho fumanoe hore Urolithins e thibela ts'ebetso ea NF-κB factor, e bohlokoa bakeng sa taolo ea ho ruruha. Ebile, bafuputsi ba lumela hore sena ke sona lebaka la mantlha la li-urolithin tse khahlanong le ho ruruha.

● Thepa ea Anti-Carcinogenic
Li-Urolithin li amahanngoa le thepa e khahlanong le mofetše, mme mochini oa thepa ena o boletsoe kaholimo. Leha ho le joalo, melemo ea thepa ena e boletsoe ka tlase:

1.Tšireletso ho tsoa Kankere ea Prostate
Ho fumanoa li-Urolithin 'meleng hangata ho etsoa ka ho sebelisa mali kapa moroto; leha ho le joalo, li ka bonoa kholoneng ea banna le basali le tšoelesa ea senya ea banna.

Ka lebaka la phumano ena, bafuputsi ba ile ba leka ho lekola hore na melemo ea metsoako ea lik'hemik'hale e ea bonahala tšoelesa ea senya joalo ka ha e le ka har'a kolone. Kahoo, ho entsoe thuto, 'me liphetho tsa eona li paka hore Urolithin e na le tšireletso ho tšoelesa ea senya.

Ho fumanoe hore Urolithin A le Urolithin B, hammoho le Urolithin C le Urolithin D li ile tsa thibela enzyme ea CYP1B1 mokokotlong oa senya. Enzyme ena ke sepheo sa chemotherapy mme e ne e thibetsoe ka matla ke Urolithin A, ha e bapisoa le li-urolithin tse ling. Ba boetse ba thibetse CYP1A1, leha ho le joalo, ho hlokahala hore ho be le li-urolithin tse phahameng ho hlahisa sephetho seo.

Phuputso e 'ngoe e ile ea etsoa ho ithuta litlamorao tsa ts'ireletso ea senya ea Urolithins. Ho fumanoe hore Urolithin A e na le tšusumetso e khahlanong le mofets'e ho mofets'e oa tšoelesa ka bobeli, p53 e its'etleha le p53 ka mokhoa o ikemetseng.

2.Topoisomerase 2 le thibelo ea CK 2
Li-Urolithin li na le thepa e khahlanong le mofets'e ka ho thibela litsela tse 'maloa tsa limolek'hule tse lebisang ho thibelo ea kholo ea mofets'e ka kotloloho kapa ka kotloloho. Enzyme ea CK2 ke enzyme ea bohlokoa e nkang karolo litseleng tse joalo tsa limolek'hule, mme mosebetsi oa eona oa mantlha e le ho khothaletsa ho ruruha le mofetše.

Li-Urolithin li thibela litsela tse fapaneng ho fihlela enzyme e fumanehang hohle, CK2 hore qetellong e thibele matla a eona, joalo ka thepa ea eona e khothalletsang mofets'e. Urolithin A e bonts'itsoe e le matla CK2 inhibitor, ka silico.

Ka mokhoa o ts'oanang, thibelo ea Topoisomerase 2 ho lumeloa hore e na le litlamorao tse khahlanong le mofets'e. Ebile, mochini ona o sebelisoa ke mahlahana a mang a chemotherapy joalo ka Doxorubicin. Phuputsong ea haufinyane, ho fumanoe hore Urolithin A e matla ho feta Doxorubicin ka ho thibela Topoisomerase 2, ka hona, e kopa hore e ekelletsoe tataisong ea hona joale ea kalafo ea mofets'e o itseng.

● Thepa ea Antibacteria
Likokoana-hloko tsa Urolithin li ipapisitse le Quorum Sensing Inhibition e tlosang bokhoni ba kokoana-hloko ea ho buisana, ho sisinyeha le ho theha lisosa tsa bongata. Ke mokhoa oa bohlokoa oa ho phela ha libaktheria, 'me thibelo ea eona ke Urolithins e bolaea kokoana-hloko.

Thepa e ka sehloohong ea lithibela-mafu ea Urolithin ke bokhoni ba eona ba ho sireletsa mala ho feta Yersinia enterocolitica. Ebile, Urolithins e amahanngoa le ho feto-fetoha ha limela tsa ka mpeng, limela tse tšoanang tse ikarabellang bakeng sa tlhahiso ea tsona pele. Sena se bohlokoa haholo hobane ke lintho tse ikhethileng tsa limela tse ka eketsang tlhahiso ea Urolithins.

● Thepa ea Anti Estrogenic le Estrogenic
Li-Urolithin li tlama ho li-receptor tsa Estrogen ebe li hlahisa thepa ea estrogenic le anti-estrogenic ka bobeli. Sena se e etsa mokhethoa ea hloahloa bakeng sa Selective Estrogen Receptor Modulators kapa li-SERM, e leng mochini o ka sehloohong oa ho ba le phello e ntle sebakeng se le seng sa 'mele le phello e thibelang sebaka se seng sa' mele.

Ho e 'ngoe ea lithuto tse entsoeng ka litlamorao tsa li-urolithin ho li-receptor tsa estrogen, ho fumanoe hore bona, haholo-holo urolithin A, ba thibela lipolelo tsa liphatsa tsa lefutso tsa lisele tsa mofets'e tsa "end-endometrial" tse hlahisang khatello ea mofetše oa endometrium. Endometrial hypertrophy ke phello e tloaelehileng ea litlamorao tsa estrogen ka mor'a neoplasia joalo ka basali ba sebelisang kalafo ea li-hormone, mme ts'ebeliso ea li-urolithin ho lumeloa hore e na le tšireletso ho endometrium. Leha ho le joalo, lipatlisiso tse ling li hloka ho etsoa pele Urolithins e ka ba moriana o latelang oa SERM.

● Ho thibela liprotheine Glycation
Boteng ba lihlahisoa tse tsoetseng pele tsa pheletso ea glycation ke letšoao la hyperglycemia le behelang batho kotsing ea lefu la tsoekere le amanang le lefu la pelo kapa lefu la Alzheimer's. Urolithin A le Urolithin B li bonts'itsoe hore li na le phello e khahlanong le glycation e thibelang litlhapa tsa pelo le ho fokotsa menyetla ea ho fetoha ha methapo ea kutlo haholo.

Kahoo, ho lumeloa hore thibelo ea protheine glycation ke Urolithins e na le litlamorao tsa pelo le tšireletso ea pelo.

Melemo ea Urolithin A e boletsoe ka tlase mona:

● Ho eketsa nako ea bophelo
Ho tsofala, khatello ea maikutlo le mathata a itseng a ka senya mitochondria, e bohlokoa bakeng sa tlhahiso le tšebeliso e tloaelehileng ea matla 'meleng. Ho feta moo, mitochondria hangata e bitsoa 'matla a sele', ho bolelang bohlokoa ba ona bakeng sa tšebetso e tloaelehileng ea sele. Kahoo, tšenyo efe kapa efe ntlong ena ea motlakase e ka ama sele le hampe mme ea fokotsa nako ea bophelo ba eona.

Li-Urolithin li baka tšusumetso e itseng e tsejoang e le mitophagy e lumellang 'mele ho tlosa mitochondria e senyehileng, ho sa tsotelehe lebaka la tšenyo, mme e eketsa nako ea bophelo. Ho ipapisitsoe le boholo ba tšenyo, mitochondria e ka sebelisoa hape bakeng sa limatlafatsi le tlhahiso ea matla.

● Ho thibela methapo ea kutlo
Joalokaha ho boletsoe kaholimo, li-urolithin li na le thepa e khahlanong le ho ruruha mme ke thepa ena e khothalletsang sebopeho sa lisele tsa neuronal bokong, se nang le phello e ntle ho ts'ebetsong le ho boloka mohopolo. Ho feta moo, Urolithin A e sireletsa khahlanong le methapo ea methapo e bonoang ke lefu la Alzheimer, ka hona, litlamorao tsa ts'ireletso ea methapo.

● Thibela Kankere ea Prostate
Urolithin A e na le thepa e khahlanong le mofets'e empa e bonahala haholo maemong a mofets'e oa senya, ka lithuto tse 'maloa tse khothalletsang ts'ebeliso ea kharenate le mehloli e meng ea Urolithins bakeng sa kalafo ea mofetše oa Prostate.

● Tšoara Botenya
Urolithin A e na le litlamorao tse khahlano le botenya hobane ha e thibele feela ho bokellana ha lisele tsa mafura 'meleng empa hape e thibela matšoao a ikarabellang bakeng sa adipogenesis. Phuputsong e entsoeng ka mefuta ea liphoofolo, ho fumanoe hore Urolithin A e na le phello e phahameng ho lihormone tsa T3 tsa qoqotho, e leng se hlahisang tšebeliso e eketsehileng ea matla ho litoeba. Sena se baka thermogenesis mme se etsa hore mafura a sootho a qhibilihe, ha mafura a masoeu a ntse a susumetsoa hore e be sootho.

Thutong e ts'oanang, ho fumanoe hore URolithin A e na le tšusumetso e thibelang botenya le ho litoeba tse fepetsoeng lijo tse nang le mafura a mangata. Sena se bontša ts'episo e kholo mabapi le botenya mme bafuputsi ba kopile ts'ebeliso ea batho ea liphuputso tsena ho khona ho sebelisa sets'oants'o sena ho loants'a seoa sa botenya.

Melemo ea Urolithin B e ka tlase mona:

● Qoba ho senyeha ha mesifa
Urolithin B e arolelana melemo e meng ea Urolithin A empa e na le molemo o le mong o ikhethang, o ikhethileng o le mong. Urolithin B e tsejoa ho thibela tahlehelo ea mesifa maemong a mmele le a mafu. Ho feta moo, e khothalletsa kholo ea masapo ka ho eketsa liprotheine tse ngata mesifa.

E boetse e na le tšusumetso e thibelang ho fokola ha mesifa joalo ka ha ho bonoe phuputsong e entsoeng ho litoeba tse neng li khaotsoe methapo ea methapo. Sena se ka be se lebisitse ho senyeha ha mesifa empa litoeba li kentsoe lipompo tsa mini osmotic tse tsoelang pele ho ba fa Urolithin B. Ho fumanoe hore litoeba tsena li hatelletsoe tseleng ea bona ea ubiquitin-proteasome, e lebisitseng ho hlaka ho hlakileng ha mesifa atrophy leha e na le methapo ea methapo ea methapo. .

Tekanyo ea Urolithins

Li-Urolithin li tsoa mefuteng ea tlhaho 'me litlatsetso tsa tsona li nkuoa li mamelloa hantle ntle le moqolotsi oa litaba ea chefo. Leha ho le joalo, ho bohlokoa ho hopola hore metsoako ena e ntse e le tlasa lipatlisiso mme e na le meeli ea litekanyetso e lokelang ho lateloa ka tieo.

● Urolithin A
Kamora ho etsa lipatlisiso tse pharalletseng ka melemo ea Urolithin A, ho bile le lithuto tse 'maloa tsa lipatlisiso tse entsoeng ho lekola litekanyetso tse nepahetseng tsa k'hemik'hale ena. Phuputso ea Absorption, Digestion, Metabolism, le Elimination e ile ea etsoa ho sekaseka likarolo tsa kompone.

Phuputso e arotsoe habeli, ho latela palo ea matsatsi, mme ho fumanoe hore thuto ea matsatsi a 28 le 0, 0.175, 1.75, le 5.0% ea Urolithin A e kopaneng le lijo le matsatsi a 90 ho ithuta le 0, 1.25, 2.5, le 5.0% Urolithin A e kopantsoeng lijong ha ea bontša liphetoho lipakeng tsa kliniki, chemistry ea mali, kapa hematology, mme e ne e sa bolele mekhoa efe kapa efe e chefo. Lithuto ka bobeli li bile le tekanyetso e phahameng ka ho fetisisa e lekiloeng ho 5% UA ka boima ba 'mele lijong tse lebisitseng litekanyetsong tse latelang; 3451 mg / kg BW / letsatsi ho banna le 3826 mg / kg BW / ka letsatsi ho basali thutong ea molomo ea matsatsi a 90.

● Urolithin B
E ts'oanang le Urolithin A, Urolithin B e ile ea ithutoa haholo ho lekola litekanyetso tse phethahetseng. Le ha ho le bohlokoa ho hlokomela hore lithuto li shebane le litekanyetso tse bolokehileng ho fihlela kholo e ntle ea mesifa. Tekanyo ena e fumanoe e le 15uM, bakeng sa banna le basali, ho sa tsotelehe boima ba eona.

● Urolithin A 8-Methyl Ether
Motsoako ona le ona oa sebelisoa, haholo hobane ke lipakeng nakong ea tlhahiso ea Urolithin A. Leha ho le joalo, ha ho lipatlisiso tse lekaneng tse entsoeng bakeng sa tekanyetso e nepahetseng e lokelang ho khethoa bakeng sa Urolithin ena e khethehileng.

Mehloli ea Lijo tsa Urolithins

Li-Urolithin ha li fumanoe ka tlhaho mohloling ofe kapa ofe oa lijo, leha ho le joalo, li fumanoa e le li-ellagitannins. Li-tannin tsena li fetoha acid e ellagic, e tsoelang pele ho sebelisa Urolithin A 8-Methyl ether, ebe e kena Urolithin A, mme qetellong, Urolithin B. Lijo tse ruileng Urolithins ke tsena:

Mohloli oa lijoEllagic acid
Litholoana (mg / 100g boima bo bocha)
Maberebere a matsó150
Tse tala tse ntšo90
Li-boysenberries70
Litholoana tsa leru315.1
kharenate> 269.9
Lihlahla tse tala270
Rose letheka109.6
Fragole77.6
Jeme ea fragola24.5
Lihlahla tse tala tse mosehla1900
Linate (mg / g)
Ma-Pecane33
Li-walnuts59
Lijo (mg / L)
Lero la kharenate811.1
Cognac31-55
Veine e khubelu ea khale33
whisky1.2
Peo (mg / g)
Tse tala tse ntšo6.7
Tse tala tse khubelu8.7
Li-boysenberries30
mango1.2


Joalokaha ho bonoa tafoleng, Cloudberries ke litholoana tse nang le li-Ellagitannins tse phahameng ka ho fetisisa le Ellagic acid, 'me kharenate ke motsotsoana o haufi. Lero la kharenate, leha ho le joalo, ke mohloli o matla ho feta, makhetlo a ka bang makhetlo a mararo ho feta a Cloudberries.

Ho bohlokoa ho hlokomela hore likahare tsa ellagic acid mehloling ea lijo ha li lekane le urolithin e lekanang le 'mele. Ho fumaneha ha li-URolithin ho its'etleha haholo ho li-microbiota tsa motho e mong le e mong.

Hobaneng ha o lokela ho reka ho fektheri ea rona ea moetsi?

Urolithin Powder A le Urolithin Powder B li fumaneha ka bongata, fekthering ea rona ea tlhahiso e kopanyang tlhahiso, lipatlisiso, nts'etsopele le thekiso ea litlatsetso tse joalo. Lihlahisoa tsa rona li etsoa ka ho nepahala ho fetelletseng ho latela melao eohle ea ts'ireletso, e netefatsang boleng bo phahameng le polokeho ea sehlahisoa sa hoqetela. Lihlahisoa tsohle li batlisisoa pele ho tlhahiso 'me li lekoa hantle nakong ea tlhahiso le kamora ho fihlella litekanyetso tsa hau tsa boleng.

Kamora tlhahiso, lihlahisoa li lekoa lilabakeng tsa rona nako e 'ngoe hape ho lekola boleng, potency le polokeho ea li-powder tsa Urolithin le lihlahisoa tse ling. Ha li se li loketse ho ajoa, lihlahisoa li pakiloe ebe li bolokoa litsing tse loketseng, mochesong o nepahetseng ha o ntse o latela litataiso tsohle ho netefatsa hore sehlahisoa sa boleng bo holimo sea u fihlela. Li-powder tsa Urolithin ha li pepesetsoe ke khanya ea letsatsi nakong ea lipalangoang, ho paka kapa ho boloka hobane li ka senya sehlahisoa sa ho qetela.

Ho reka phofo ea Urolithin A le phofo ea Urolithin B fekthering ea moetsi oa rona ho tiisa sehlahisoa sa boleng bo holimo ka theko e tlase haholo.

Tlhaloso:

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  2. Guada M, Ganugula R, Vadhanam M, Ravi Kumar MNV. Urolithin A e fokotsa Nephrotoxicity e hlahisitsoeng ke Cisplatin ka ho thibela ho ruruha ha renal le apoptosis ho Model Rat Model. J Pharmacol Phekolo ea Ther. 2017; 363 (1): 58-65. doi: 10.1124 / jpet.117.242420.
  3. Juan Carlos Espín, Mar Larrosa, María Teresa García-Conesa, Francisco Tomás-Barberán, "Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derives Metabolites: The Evidence So Far", Bopaki bo Thehiloeng Bopaki le Mekhoa e meng, vol. 2013, Article ID 270418, maqephe a 15, 2013. https://doi.org/10.1155/2013/270418.
  4. Lee G, Park JS, Lee EJ, Ahn JH, Kim HS. Mefuta e khahlanong le ho ruruha le antioxidant ea urolithin B ho microglia e sebelisitsoeng. Phytomedicine. 2019; 55: 50-57. doi: 10.1016 / j.phymed.2018.06.032.
  5. Han QA, Yan C, Wang L, Li G, Xu Y, Xia X. Urolithin A e thibela ho se sebetse ha likhomo-LDL tse bakoang ke endothelial ka mokhoa o mong ka ho hlophisa tsela ea microRNA-27 le ERK / PPAR-γ. Lijo tsa Mol Nutr. 2016; 60 (9): 1933-1943. doi: 10.1002 / mnfr.201500827.