Urolithin (1143-70-0) (1139-83-9) - Feme ea moetsi

Urolithin

Cofftek e na le bokhoni ba tlhahiso ea bongata le phepelo ea urolithin a le urolithin b tlasa boemo ba cGMP.

Selelekela ho Urolithins

Li-Urolithin ke metabolite ea bobeli ea ellagic acid e tsoang ho ellagitannins. Ho batho ellagitannins e fetoloa ke mala microflora ho ba ellagic acid e fetoloang ho ba urolithins A, urolithin B, urolithin C le urolithin D mala a maholo.

Urolithin A (UA) ke metabolite e atileng ka ho fetisisa ea ellagitannins. Leha ho le joalo, urolithin A ha e tsejoe hore e hlaha ka tlhaho mehloling efe kapa efe ea lijo.

Urolithin B (UB) ke metabolism e ngata e hlahisoang ka mpeng ka phetoho ea li-ellagitannins. Urolithin B ke sehlahisoa sa hoqetela kamora hore lihlahisoa tse ling tsa urolithin li phethiloe. Urolithin B e fumanoa ka morong joalo ka urolithin B glucuronide.

  Urolithin A 8-Methyl Ether ke sehlahisoa se mahareng nakong ea ts'ebeliso ea Urolithin A. Ke metabolite ea bobeli ea bohlokoa ea ellagitannin ebile e na le thepa ea antioxidant le e khahlanong le ho ruruha.

Mokhoa oa ketso ea urolithin A le B

● Urolithin A e khothalletsa mitophagy
Mitophagy ke mofuta o le mong oa autophagy o thusang ho tlosa mitochondrial e senyehileng bakeng sa ts'ebetso ea bona e nepahetseng. Autophagy e bua ka ts'ebetso e akaretsang eo litaba tsa cytoplasmic li nyenyefalitsoeng 'me ka lebaka leo li phetisetsoang ha li-mitophag ke mokhoa o nyarosang le oa ho nchafatsa oa mitochondria.

Nakong ea botsofali ho fokotseha ha autophagy ke karolo e 'ngoe e lebisang ho fokotseheng ha ts'ebetso ea mitochondrial. Ho feta moo, khatello ea mali e ka lebisa ho ho itšireletsa tlaase. Urolithin A na le bokhoni ba ho felisa mitochondria e senyehileng ka ho khetha autophagy.

● Mefuta e thibelang likokoana-hloko
Ho imeloa kelellong ho etsahala ha ho ba le ho leka-lekana pakeng tsa li-radicals tsa mahala le antioxidant 'meleng. Li-radicals tsena tse sa lefelloeng haholo hangata li amahanngoa le mafu a mangata a sa foleng a kang mafu a pelo, lefu la tsoekere le mofets'e.

Urolithins A le B li bonts'a litlamorao tsa antioxidant ka bokhoni ba tsona ba ho fokotsa li-radicals tsa mahala mme ka ho khetheha maemo a kenang a oksijene a maiketsetso a oksijene (ROS) hape a thibela lipid peroxidation mefuteng e meng ea lisele.

Ho feta moo, li-urolithin li khona ho thibela li-enzyme tse nang le oxidizing, ho kenyelletsa le monoamine oxidase A le tyrosinase.

● Lintho tse thibelang ho ruruha
Ho ruruha ke mokhoa oa tlhaho oo 'mele ea rona e loantšang ntho efe kapa efe e oeleng joalo ka ts'oaetso, likotsi le likokoana-hloko. Leha ho le joalo, ho ruruha ho sa foleng ho ka ba kotsi 'meleng kaha hona ho amahanngoa le mathata a fapaneng a kang asma, mathata a pelo le mofetše. Ho ruruha ho sa foleng ho ka hlaha ka lebaka la ho ruruha ho matla ho sa phekoleheng, tšoaetso kapa esita le methapo ea mmele e sa lefelloeng.

Urolithins A le B e bonts'a thepa e khahlanong le ho ruruha ka ho thibela tlhahiso ea nitric oxide. Ka ho khetheha ba thibela protheine ea nitric oxide synthase (iNOS) ea inducible le polelo ea mRNA e ikarabellang bakeng sa ho ruruha.

● Litla-morao tse thibelang likokoana-hloko
Likokoana-hloko tse kenyeletsang libaktheria, li-fungus le likokoana-hloko li etsahala ka tlhaho tikolohong ea 'mele oa motho. Le ha ho le joalo, likokoana-hloko tse 'maloa tse bitsoang li-pathogen li ka baka mafu a tšoaetsanoang joalo ka ntaramane, semola le mala.

Urolithin A le B li khona ho bonts'a ts'ebetso ea antimicrobial ka ho thibela sensor ea quorum. Sensor ea Quorum ke mokhoa oa puisano oa baktheria o thusang libaktheria ho bona le ho laola lits'ebetso tse amanang le ts'oaetso joalo ka virilence le motility.

● Ho thibela protein glycation
Glycation e bua ka karolo e se nang enzymatic ea tsoekere ho lipid kapa protheine. Ke sehlahisoa sa bohlokoa sa lefu la tsoekere le mafu a mang hammoho le botsofali.

Ho ba le protheine e phahameng ke phello ea bobeli ea hyperglycemia e na le karolo e kholo mathateng a amanang le pelo le methapo e kang lefu la tsoekere le lefu la Alzheimer's.

Urolithin A le B li na le thepa ea anti-glycative e itšetlehileng ka litekanyetso tse ikemetseng mesebetsing ea bona ea antioxidant.

Melemo ea Urolithin A le B

Li-Urolithin li na le litlamorao tse ngata tse ntle tse tšehelitsoeng ke bopaki bo thehiloeng lipatlisisong ba thepa ea anti-inflammatory, anti-carcinogenic, antioxidant le antimicrobial. Melemo ea Urolithin A e amana haufi le melemo ea urolithin B. Ka tlase ke melemo e tlalehiloeng ho tsoa ho li-urolithin;
Melemo ea Urolithin A
(1) E ka lelefatsa nako ea bophelo
Urolithin A e kenyelletsa sebopeho ka ho khetha ka boomo ho tlosa mitochondria e senyehileng. Sena se boetse se netefatsa hore li-mitochondria li sebetsa hantle hape. Mitochondria hangata e senyeha ka lilemo le ka lebaka la khatello ea maikutlo. Ho tlosa mitochondria e senyehileng ho bapala karolo ea ho atolosa nako ea bophelo.

Thutong ea liboko, urolithin Tlatsetso e sebelisitsoeng ho 50 µM ho tloha sethaleng sa lehe ho fihlela lefung e fumanoe e le ho eketsa bophelo ba bona ka 45.4%.

Phuputsong e 'ngoe e entsoeng ka 2019 ho sebelisoa li-fibroblast tsa batho tse senescent, urolithin A supplement e fumanoe e bonts'a bokhoni ba ho loants'a botsofali. E khonne ho eketsa mofuta oa 1 collagen expression hape e fokotsa polelo ea matrix metalloproteinase 1.

Boithuto bo nyane ba motho bo boetse bo bonts'a hore UA e khonne ho ntlafatsa ts'ebetso ea mitochondrial le bophelo bo botle ba masapo ho batho ba tsofetseng ha ba fanoa ka molomo ho 500-1000mg nako ea libeke tse 'ne.

(2) Thusa ho thibela mofetše oa senya
Li-urolithin le moetapele oa tsona, ellagitannins, li na le thepa ea anti-cancer. Ba khona ho thibela bongata ba lisele tsa mofetše ka ho potoloha le ho potoloha ha lisele. Apoptosis e bua ka lefu le hlophisitsoeng leo ho lona 'mele o felisang lisele tse nang le mofetše le lisele tse ling tse nang le tšoaetso.

Phuputsong ea litoeba tse kentsoeng ka lisele tsa mofetše oa batho, li-ellagitannins metabolites (Urolithin A) li fumanoe li thibela kholo ea mofets'e oa lefu la senya. Phuputso e boetse e tlaleha ho phahama ho hoholo ha metabolites ka har'a tšoelesa ea senya, lera le mala.

(3) Ntlafatso ea kelello
Urolithin A e khona ho sireletsa li-neuron ho tloha lefung hape e ka baka le neurogeneis ka ho saena le ho tšoaetsana le mats'oafo.

Phuputsong ea litoeba tse nang le bothata ba ho lebala, urolithin A e fumanoe e ntlafatsa ho senyeha hoa kelello le ho sireletsa li-neuron ho tloha apoptosis. Sena se fana ka maikutlo a hore UA e ka sebelisoa ho phekola lefu la Alzheimer's (AD).

(4) Bokhoni bo khahlanong le botenya
Patlisiso e bonts'a hore li-ellagitannins li khona ho thibela ho bokellana ha lipid le li-tag tsa adipogenic tse kang protheine ea pele ea kholo ea ho hola 2 hammoho le protheine e tlamang mats'oafo ka ho ts'oaroa ha cell cell.

Urolithin A e fumanoe ka ho khetheha ho ntlafatsa kutloisiso ea insulin kahoo e thibela nts'etsopele ea botenya.

Phuputsong ea litoeba tse nang le botenya bo feteletseng, urolithin A tlatselletso e fumanoe ho thibela botenya bo bakoang ke ho ja le ho senyeha hoa metabolic ka litoeba. Phuputso e bontšitse hore kalafo ea UA e eketsa tšebeliso ea matla ka hona boima ba mmele o tlase.

Melemo ea Urolithin B
Lisebelisoa tsa Urolithin B li boetse li na le melemo e 'maloa ea bophelo bo botle' me boholo ba tsona li ts'oana le melemo ea urolithin A.

(1) Bokhoni bo khahlanong le mofets'e
Thepa e khahlanong le ho ruruha ea urolithin B e e etsa khetho e ntle ea ho loants'a mofetše. Bafuputsi ba bang ba tlalehile bokhoni bona ho li-fibroblasts, microphages le lisele tsa endothelial.

Boithuto bo tlalehile hore UB e thibela mefuta e fapaneng ea mofets'e joalo ka mofetše oa senya, colon le lefu la senya.

Phuputsong e amang lisele tsa mofetše oa colon ea motho, li-ellagitannins, ellagic acid le urolithins A le B li ile tsa hlahlojoa bakeng sa bokhoni ba tsona ba ho thibela mofetše. Ba tlaleha hore kalafo tsohle li atlehile ho thibela lisele tsa mofetše. Ba sitisitse lisele tsa mofetše ka bongata ka ho potoloha ha lisele ka mekhahlelo e fapaneng le ka ho susumetsa apoptosis.

(2) E ka thusa ho loants'a khatello ea mali
Urolithin B e na le thepa e ntle ea antioxidant ka ho fokotsa mefuta e fapaneng ea mefuta ea oksijene le lipid peroxidation mefuteng e meng ea lisele. Maemo a phahameng a ROS a amahanngoa le mathata a mangata a kang lefu la Alzheimer's.

Phuputsong e nang le lisele tsa neuronal tse pepesitsoeng khatello ea oxidative, tlatsetso ea urolithin B hammoho le urolithin A li fumanoe ho sireletsa lisele khahlanong le oxidation ka hona ho ile ha eketsa pholoho ea sele.

(3) Urolithin B ntlafatsong ea mohopolo
Urolithin b ho tlalehiloe hore e ntlafatsa boemo ba mali bo thibelang mali. Sena se matlafatsa ts'ebetso ea kelello.

Boithuto bo bontša hore urolithin B e ka ntlafatsa mohopolo oa memori ka ho ntlafatsa ts'ebetso e akaretsang ea kelello.

(4) E thibela ho lahleheloa ke mesifa
Ho lahleheloa ke mesifa ho ka hlaha ka lebaka la mabaka a fapaneng a joalo ka ho hloka taolo, ho tsofala le khaello ea protheine lijong. Ho ka sebelisoa mehato e 'maloa ea ho emisa, ho fokotsa kapa ho fokotsa ho lahleheloa ke mesifa ho kenyeletsa, boikoetliso, lithethefatsi le li-amino acid hammoho le polyphenols li ka sebelisoa.

Li-urolithins li ka khethoa e le li-polyphenols mme li bapala karolo ea ho thibela tahlehelo ea mesifa ka ho kenya tšebetsong protheine ea mesifa hape le ho fokotsa ho fokola.

Phuputsong le litoeba, li-supplement tsa Urolithin B tse tsamaisoang ka nako e telele li fumanoe li matlafatsa nts'etsopele ea mesifa ha mesifa e ne e bonoa e le kholo.  

(5) Urolithin B o loana le ho ruruha
Urolithin B e na le thepa ea khahlanong le ho fokola ka ho fokotsa mats'oao a ho chesa.

 Phuputsong ea likhoto tse nang le lesapo la mokokotlo la mokokotlo, urolithin B e fumanoe e le ho ntlafatsa likotsi tsa menoana. E ntlafalitse ts'ebetso ea renal, morphology ea monoana le ho fokotsa mats'oao a ho lemala hoa renal. Sena se bontša hore UB e ne e khona ho fokotsa ho ruruha ha renal.

Melemo ea Synergistic ea urolithin A le B
Liphello tsa synergistic le tsona li tlalehiloe ka motsoako oa urolithin A le B ts'ebetsong ea ts'ebetso le bokhoni. Phuputso e boletse hore motswako ona o ka sebelisoa ho phekola kapa ho thibela mathata a amanang le 'dementia' joalo ka ho tšoenyeha kapa lefu la Alzheimer's.

Melemo e meng e amanang le urolithins ke;
  • neuroprotection
  • E ntlafatsa lefu la metabolic

Mehloli ea lijo ea Urolithin A le B

Li-urolithin ha li tsejoe ho fumaneha ka tlhaho mehloling efe kapa efe ea lijo. Ke sehlahisoa sa phetoho ea li-ellagic acid tse nkiloeng ho ellagitannins. Ellagitannins e fetoloa li-ellagic acid ke gut microbiota mme ellagic acid e fetoloa hape ka metabolites ea eona (urolithins) ka mala.

  Li-ellagitannins li hlaha ka tlhaho mehloling ea lijo joalo ka likharenate, monokotsoai o kenyelletsang fragole, tse tala, monokotšoai le monokotšoai, morara oa muscadine, lialmonde, li-guava, tee le linate tse kang walnuts le li-chestnut hammoho le lino tse tsofetseng tsa oak mohlala veine e khubelu le whisky Meqomo ea eike.

Ka hona re ka phethela lijo tsa urolithin A le lijo tsa urolithin B ke lijo tse nang le ellagitannin. Ke habohlokoa ho hlokomela hore ellagitannin bioavailability e na le moeli ha methabolite ea eona ea bobeli (urolithins) e fumaneha habonolo.

Metsoako ea Urolithins le tlhahiso li fapana haholo har'a batho ho tloha ha phetoho e tsoang ho ellagitannins e its'etleha ka microbiota ka maleng. Ho na le libaktheria tse ikhethang tse amehang phetohong ena 'me lia fapana hara batho moo ba bang ba nang le microbiota e phahameng, e tlase kapa e se nang eona. Mehloli ea lijo le eona ea fapana maemong a ellagitannins. Kahoo melemo e ka bang teng ea ellagitannins e fapana ho ea ka batho.

Lisebelisoa tsa Urolithin A le B

Li-supplements tsa Urolithin A hammoho le li-supplements tsa Urolithin B li fumaneha habonolo 'marakeng joalo ka mohloli oa lijo tse nang le ellagitannin. Urolithin A li-supplement le tsona li fumaneha habonolo. Haholo-holo likharenate tse tlatselletsang li rekisitsoe haholo mme li sebelisitsoe ka katleho. Lisebelisoa tsena li entsoe ka litholoana kapa linate ebe li etsoa ka mokelikeli kapa phofo.

Ka lebaka la phapang ea li-ellagitannins tse kenang lijong tse fapaneng, bareki ba urolithin ba e reka ho nahanisisa ka mohloli oa lijo. Ho joalo le ha o fumana phofo ea urolithin B kapa litlatsetso tsa metsi.

Lithuto tse 'maloa tsa bongaka tse entsoeng ka urolithin A phofo kapa B ha li so ka li tlaleha litla-morao tse tsoang ho tsamaiso ea li-supplement tsena.

Tlhaloso:

  1. Garcia-Munoz, Cristina; Vaillant, Fabrice (2014-12-02). "Phello ea Metabolic ea Ellagitannins: Litlamorao ho Bophelo bo Botle, le Lits'ebetso tsa Patlisiso bakeng sa Lijo Tse Sebetsang Tse Sebetsang". Litlhahlobo tse Bohlokoa ho Saense ea Lijo le Phepo e Ntle.
  2. Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 Pulungoana 2009). "Li-Urolithin, mala a likokoana-hloko a methapo ea likharenate ellagitannins, e bonts'a tšebetso e matla ea antioxidant tekong e thehiloeng seleng". J Agric Lijo Chem.
  3. Bodwell, Graham; Pottie, Ian; Nandaluru, Penchal (2011). "Sesebelisoa sa Inverse Electron-Demel Diels-Alder-Based Total Synthesis ea Urolithin M7".