Sodium ea Citicoline (33818-15-4)

E se eka 8, 2021

Cofttek ke moetsi oa phofo ea Citicoline Sodium (CDP Choline Sodium) Chaena. Fektheri ea rona e na le sistimi e felletseng ea taolo ea tlhahiso (ISO9001 & ISO14001), e nang le tlhahiso ea khoeli le khoeli ea 220kg.

 


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 1kg / mokotla, 25kg / Drum

Citicoline Sodium (CDP Choline Sodium)(33818-15-4) Slitšobotsi

Name: Citicoline Sodium (CDP Choline Sodium)
CAS: 33818-15-4
Ho hloeka 98%
Limolek'hule Mokgwa wa ho Nahana: C14H25N4NaO11P2
Boima ba limolek'hule: 510.308 g / mol
Melt Point: > 240 ° C
Lebitso la k'hemik'hale Sodium ea Citicoline; Cdp-choline sodium
Li-synonyms: Sodium [[(2S,3R,4S,5S)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]2-(trimethylazaniumyl)ethyl phosphate
InChI Key: YWAFNFGRBBBDDD-KDVMHAGBSA-M
Halofo ea bophelo: Lihora tse 56
Solubility: Soluble ho DMSO, Metsi (Hanyane)
Boemo ba ho Boloka: E omme, e lefifi ebile e le 0 - 4 C ka nako e khuts'oane (matsatsi ho isa ho libeke) kapa -20 C nako e telele (likhoeli ho isa ho lilemo).
e sebetsa joang: Citicoline Sodium ke sesebelisoa sa methapo ea kutlo le tlatsetso ea lijo
Ponahalo: Palo e tšoeu e tšoeu

 

Sodium ea Citicoline (33818-15-4) Ponahalo ea NMR

Citicoline Sodium (33818-15-4) Spectrum ea NMR

Haeba o hloka COA, MSDS, HNMR bakeng sa sehlopha ka seng sa sehlahisoa le tlhaiso-leseling e ngoe, ka kopo ikopanye le rona mookameli oa papatso.

 

ke eng Citicoline Sodium (CDP Choline Sodium)(33818-15-4) ?

Citicoline Sodium (CDP-choline Sodium, cytidine 5'-diphosphocholine) phofo ke phepo e qhibilihang metsing e sebetsang e le selelekela sa choline le cytidine kahare ho bokong (eo hamorao e fetohang uridine). Ho batho, Citicoline Sodium ke limatlafatsi tsa bohlokoa kaha karolo ea eona ea ho fokotsa likotsi tsa bokooa ba methapo ea methapo, lefu la mafura a sebete le mafu a mang a tlalehiloe. CDP-choline Sodium ke e 'ngoe ea li-phospholipid tse tharo tse nang le choline tse ka eketsoang ka molomo (tse ling tse peli ke alpha-GPC le phosphatidylcholine).

 

Citicoline Sodium (CDP Choline Sodium)(33818-15-4) melemo e

CDP-choline e kenya tšebetsong biosynthesis ea sebopeho sa phospholipids ka lera la neuronal, e eketsa metabolism ea bokong mme e sebetsa maemong a li-neurotransmitters tse fapaneng. Kahoo, ho netefalitsoe ka liteko hore CDP-choline e eketsa maemo a noradrenaline le dopamine ho CNS.

Tlatsetso ena e etsoa ho thibela kapa ho phekola ho kula ha mohopolo ho amanang le botsofali ka lebaka la hore limolek'hule tseo ka bobeli li fanang ka li-neuroprotective mme li ka ntlafatsa thuto. Le hoja ho bonahala eka e sebetsa ho feta phosphatidylcholine (PC) karolong ena, karolo e itseng ka lebaka la ho eketseha ha PC palo ea bokong, potency ea eona e batla e tšoana le ea Alpha-GPC.

 

Citicoline Sodium (CDP Choline Sodium)(33818-15-4) sebelisa khanya

CDP-choline e na le mekhoa e meng eo e ka e sebelisang mabapi le ts'oaetso. E sebelisoa hangata e le sehopotso sa mohopolo bocheng, empa leha lithuto tse ling tsa litoeba li fana ka maikutlo a hore sena se ka etsahala ka molomo oa CDP-choline, ha ho na lithuto tsa batho bocheng nakong ena ka nako. Phuputso e 'ngoe e hlokometse keketseho ea tlhokomelo ka tekanyetso e tlase ea CDP-choline (e hlokang ho phetoa),' me CDP-choline e ka ba le likarolo e le komporo e khahlanong le lithethefatsi khahlanong le cocaine le (bopaki ba pele bo fana ka maikutlo a) lijo hape ..

 

Citicoline Sodium (CDP Choline Sodium)(33818-15-4) kopo

Citicoline Sodium (CDP Choline Sodium) phofo ke sesebelisoa sa methapo ea kutlo. E sebetsa ka ho ntlafatsa puisano ea lisele, e matlafatsa tšebetso ea SAMe, le ho eketsa metabolism ea tsoekere. Citicoline Sodium (CDP Choline Sodium) phofo ke nucleotide e hlahang ka tlhaho; lipakeng tseleng e kholo ea lecitin biosynthesis. Tšireletso ea meriana. E sebelisoa kalafong ea setorouku le ho sithabela hlooho. Sehlahisoa sa Neuroprotective. Citicholine e bonts'a litlamorao ho cerebral ischemia, kotsi e mpe ea boko le mathata a ho hopola. Haufinyane e bonts'itse katleho khahlanong le 'dementia' ha e fanoa le AchEIs (Acetylcholinesterase inhibitor). E bonts'a ts'ebetso ea Neuroprotective, acnticonvulsant le phello ea sedative ka lethal dose ea 150mg / kg ka likhoto. E bontšitse ts'ireletso khahlano le aluminium e bakileng ts'oaetso ea likhoto ho fokotsa maemo a phahameng a glutamate, khatello ea oksijene mme HA HO tlhahiso e fetelletseng ho hippocampus.

 

Citicoline Sodium (CDP Choline Sodium)(33818-15-4) phofo Ho rekisoa

(Moo u ka rekang Sodium ea Citicoline (CDP Choline Sodium)(33818-15-4) phofo ka bongata)

Khamphani ea rona e thabela likamano tsa nako e telele le bareki ba rona hobane re tsepamisa maikutlo mosebetsing oa bareki le ho fana ka lihlahisoa tse ntle. Haeba o rata sehlahisoa sa rona, re feto-fetoha le maemo ka mokhoa oo re ratang ho odara ka oona o lekanang tlhoko ea hau le nako ea hau ea kapele ea li-odara e tiisa hore o tla latsoa sehlahisoa sa rona ka nako. Re shebile hape le lits'ebeletso tse kenyellelitsoeng boleng. Re fumaneha bakeng sa lipotso tsa ts'ebeletso le tlhaiso-leseling ho ts'ehetsa khoebo ea hau.

Re setsebi Citicoline Sodium (CDP Choline Sodium)(33818-15-4) mofani oa phofo ka lilemo tse 'maloa, re fana ka lihlahisoa ka theko ea tlholisano,' me sehlahisoa sa rona ke sa boleng bo holimo haholo 'me se etsoa liteko tse thata, tse ikemetseng ho netefatsa hore se bolokehile hore se ka sebelisoa lefatšeng ka bophara.

 

References

[1] Tyurenkov IN, Kurkin DV, Bakulin DA, Volotova EV, Chafeev MA. [Ketsahalo ea cerebroprotective ea metformin, gosogliptin, citicoline le rialo ea GPR119 agonist ho "cerebral ischemia" tlasa liteko tsa lefu la tsoekere la mellitus]. Zh Nevrol Psikhiatr Im SS Korsakova. 2017; 117 (12. Vyp. 2): 53-59. doi: 10.17116 / jnevro201711712253-59. Se-Russia. PubMed PMID: 29411746.

[2] Jiang JJ, Xie YM, Zhang Y, Zhang YK, Wang ZM, Han B. [Litlhare tsa meriana ea Clinical tsa ente ea Shuxuening kalafong ea lipatlisiso tsa lefutso la mokokotlo tse thehiloeng ho ngoliso]. Zhongguo Zhong Yao Za Zhi. 2016 Dec; 41 (24): 4516-4520. Doi: 10.4268 / cjcmm20162407. Machaena. PubMed PMID: 28936832.

[3] Liu Y, Wang J, Xu C, Chen Y, Yang J, Liu D, Niu H, Jiang Y, Yang S, Ying H. Ts'ebetso ea li-CDP-choline tse ngata tse nang le li-enzyme tse ngata tse tsamaisoang ke moduli ea fanang ka mofani oa ATP. Appl Microbiol Biotechnol. 2017 Feb; 101 (4): 1409-1417. Doi: 10.1007 / s00253-016-7874-0. Epub 2016 Oct 13. PubMed PMID: 27738720.

[4] Giménez R, Raïch J, Aguilar J (Pherekhong 1991). "Liphetoho bokong ba striatum dopamine le li-acetylcholine receptors tse bakoang ke kalafo e sa foleng ea CDP-choline ea litoeba tse tsofalang". Koranta ea Brithani ea Pharmacology. EA-104 (3): 575–8. doi: 1111 / j.1476-5381.1991.tb12471.x. PMC1908237PMID1839138.

[5] Tardner, P. (2020-08-30). "Ts'ebeliso ea citicoline bakeng sa kalafo ea ts'oaetso ea ts'oaetso le ts'oaetso ea ts'ebeliso ea kelello: Tlhatlhobo ea meta ea lingoliloeng tsa litlhare tsa bongaka • International Journal of Environmental Science & Technology". Koranta ea Machabeng ea Saense ea Tikoloho le Theknoloji. E khutlisitsoe ka 2020-08-31.