Hobaneng ha re hloka Nicotinamide Riboside Chloride

Indasteri ea litlolo ke indasteri ea lidolara tse libilione, haholo hobane batho ba amehile haholo ka tsela eo ba shebahalang ka eona. Hona hape ke lebaka la mantlha leo ka lona lipatlisiso li mabapi le metsoako le lihlahisoa tse khahlanong le botsofali li entseng tsoelo-pele e makatsang ka nako e khuts'oane joalo. Mekhatlo e kopaneng ea lefats'e e utloisisa hore ho na le chelete e ka etsoang ka takatso ea batho ea ho lula ba le bacha ka ho sa feleng, ka hona, ho ba le lihlopha sebakeng, ho fana ka matsatsi le libeke ho fumana metsoako le lihlahisoa tse ka ntlafatsang bophelo ba letlalo. Nicotinamide Riboside kapa Niagen e fumanoe ka lebaka la patlo ena e sa khaotseng ea lihlahisoa tse khahlanong le botsofali. Le ha lihlahisoa tse ngata tse khahlanong le botsofali li fokotsa matšoao a botsofali letlalong, Niagen e fokotsa matšoao a botsofali 'meleng. Nicotinamide Riboside kapa Niagen ke mofuta oa kristale oa Nicotinamide Riboside chloride hang ha e le ka har'a 'mele, e fetoha NAD + e ikarabellang bakeng sa botsofali bo phetseng hantle le mesebetsi e meng e mengata ea bohlokoa. 

Sehloohong sena, re akaretsa likarolo tsohle tsa karolo ena ea limakatso, ho kenyelletsa melemo ea eona, litlamorao le litekanyetso tse nepahetseng.

 

Nicotinamide Riboside Chloride ke eng?

Nicotinamide Riboside Chloride kapa Niagen ke mofuta oa kristale oa Nicotinamide Riboside, e leng vithamine ea NAD + ea pele. Ha Nicotinamide Riboside e le boima ba 255.25 g / mol, Nicotinamide Riboside Chloride e boima ba 290.70 g / mol le 100 mg ea Nicotinamide Riboside Chloride e fana ka 88 mg ea Nicotinamide Riboside. NR e nkoa e sireletsehile hore e ka sebelisoa lijong.

Le ha Nikotinamide Riboside e le mofuta oa Vitamin B3, thepa ea eona e fapaneng e e etsa e fapaneng haholo le litho tse ling tsa sehlopha sa vithamine B3, joalo ka nicotinamide le niacin. Le ha Niacin e etsa hore letlalo le thunye ka ho kenya tšebetsong protheine e kopantsoeng ea GPR109A G, Nicotinamide Riboside ha e arabele ho hang ka li-receptor tsena, ka hona, ha e etse hore letlalo le siphohe, le ha le tšeloa ka tekanyo e phahameng ea litekanyetso tse 2000 mg ka letsatsi. Ho feta moo, liteko tse entsoeng ho litoeba li senotse hore Nicotinamide Riboside ke selelekela sa NAD + se lebisitseng ho spike e phahameng ka ho fetisisa Nicotinamide Adenine Dinucleotide kapa NAD + ka har'a 'mele. 

Nicotinamide Riboside e hlaha ka tlhaho lijong tsa motho mme hang ka hare ho 'mele, e fetoha NAD +, eo' mele o e hlokang bakeng sa mesebetsi e fapaneng. Mohlala, lipatlisiso tsa saense li netefalitse hore Nicotinamide Riboside Chloride kapa NAD + e fanoeng ke NR e ntlafatsa ts'ebetso ea mitochondrial le kutloisiso ea insulin ka ho kenya ts'ebetso ea lelapa la sirtuin la enzymes, le ikarabellang ho laola metabolism ea oxidative kahare ho 'mele.

Ho fihlela hajoale, ho entsoe lithuto tse hlano ho ithuta ka polokeho le katleho ea Nicotinamide Riboside mme lithuto tsena kaofela li fumane hore polokeho e bolokehile hore e ka sebelisoa ke batho.

 

Nicotinamide Riboside chloride melemo e

Pele re tšohla taba ea melemo ea Nicotinamide Riboside Chloride, ho bohlokoa ho hlakisa hore kaha Nicotinamide Riboside Chloride ke letsoai leo Nicotinamide Riboside e fumanoang ho lona, ​​melemo ea Nicotinamide Riboside Chloride e tšoana le melemo ea Nicotinamide Riboside.

 

Nicotinamide Riboside Chloride E Ntlafatsa Bolo ba Bophelo bo Botle

NAD + e entsoeng ke Nicotinamide Riboside Chloride ka hare ho 'mele e kenya li-enzyme tse khethehileng tse amanang le botsofali bo phetseng hantle. Enfelopo e 'ngoe e joalo ke li-sirtuins, tse amanang le bophelo bo ntlafalitsoeng ka kakaretso le bophelo ba liphoofolo. Boithuto ba mahlale bo pakile hore li-Sirtuins li ntlafatsa boleng ba bophelo le bophelo bo bolelele ka ho fokotsa ho ruruha, ho ntlafatsa melemo e amanang le thibelo ea khalori le ho lokisa DNA e senyehileng. NAD + e entsoeng ke Nicotinamide Riboside Chloride e boetse e kenya li-polymerase tsa Poly tse tsejoang ho lokisa DNA e senyehileng. Ho feta moo, lithuto tse 'maloa tsa saense li hokahanya tšebetso ea li-polymerase le nako e ntlafalitsoeng ea bophelo. 

 

E fokotsa menyetla ea hore motho a be le mafu a pelo

Ho tsofala le hona ho eketsa menyetla ea motho ea ho ba le mafu a pelo. Ha batho ba ntse ba tsofala, methapo ea bona ea mali e ba tenya le ho tiya, e leng se lebisang ho khatello ea mali e eketsehileng. Ha khatello ea mali kahara lijana e eketseha, pelo e tlameha ho sebetsa ka thata ho pompela mali, e lebisang ho mafu a pelo a fapaneng. NAD + e fanoeng ke Nicotinamide Riboside Chloride e fetola liphetoho tse amanang le lilemo tse bakiloeng ke methapo ea mali. Ho na le bopaki bo bongata ba mahlale bo netefatsang hore Nicotinamide Adenine Dinucleotide kapa NAD + ha e fokolise feela ho tiea ha methapo ea mali empa e boetse e laola khatello ea mali ea systolic.

 

Nicotinamide Riboside Chloride Hape E Fana ka Tšireletso ho Lisele tsa Brain

Nicotinamide Riboside e sireletsa lisele tsa boko. Phuputso e entsoeng litoeba e senotse hore tlhahiso e hlahisitsoeng ke NR ea NAD + e ekelitse tlhahiso ea protheine ea alpha ea PGC-1 ho fihlela ho 50%. Protheine ea alpha ea PGC-1 e thusa ho sireletsa lisele tsa boko khahlano le khatello ea mali le ho ntlafatsa ts'ebetso ea mitochondrial. Ka hona, ts'ebeliso ea NR bathong e sireletsa khahlanong le mafu a bakoang ke boko, a kang Alzheimer's le Parkinson. Phuputso e 'ngoe e ile ea ithuta phello ea maemo a NAD + ho batho ba nang le lefu la Parkinson. Phuputso e fihletse qeto ea hore NAD + e ntlafalitse ts'ebetso ea mitochondrial liseleng tsa stem.

 

Melemo e meng ea Bohlokoa ea Nicotinamide Riboside Chloride

Ntle le melemo e boletsoeng ka holimo, mona ke melemo e meng e mengata e tlatselletsang e amanang le Nicotinamide Riboside Chloride.

  • NR e tsejoa ho matlafatsa matla a mesifa, ts'ebetso le mamello, ka hona, tšebeliso ea NR e hokahane le ts'ebetso e ntle ea baatlelete.
  • Joalokaha ho boletsoe kaholimo, tlhahiso e hlahisitsoeng ke NR ea NAD + e lokisa DNA e senyehileng mme e fana ka tšireletso khahlano le khatello ea mali. Sena le sona se fokotsa menyetla ea motho ea ho tšoaroa ke mofetše.
  • Phuputso e ile ea lekola phello ea Nicotinamide Riboside ho metabolism liteng. Phuputso eo e ile ea fihlela qeto ea hore NR e eketsa metabolism litoeba. Le ha ho hlokahala bopaki bo eketsehileng ba mahlale mabapi le sena, bo-rasaense ba bangata ba lumela hore Nicotinamide Riboside le eona e ka ba le phello e tšoanang ho batho, ka hona, e lokela ho ba molemo ho theola boima ba 'mele.

Nicotinamide Riboside chloride

Mofuta oa Nicotinamide Riboside Chloride

Lithuto tse hlano tse entsoeng ho fihlela joale li netefalitse hore Nicotinamide Riboside e bolokehile hore e ka sebelisoa ke batho. Leha ho le joalo, lithuto tsena li thehile tse sireletsehileng Nicotinamide Riboside chloride tekanyo Moeli bakeng sa batho ba pakeng tsa 1,000 2,000 ho isa ho XNUMX XNUMX mg ka letsatsi. Leha ho le joalo, ho tlameha ho bolokoe kelellong hore lithuto tsohle tse ileng tsa sekaseka polokeho ea Nicotinamide Riboside li ne li na le sampole e nyane haholo mme ka hona, lipatlisiso tse ling lia hlokahala sebakeng sena. 

Morero oa mantlha oa Nicotinamide Riboside Chloride ke hore, ha e le hantle, ho fana ka Nicotinamide Riboside Chloride kapa Niagen 'meleng. Niagen kapa NR hangata e fumaneha ka mefuta e 'meli: matlapa le likhabapo. Bahlahisi ba bangata ba tlatsetso ba Nikotinamide Riboside ba kopanya NR le lik'hemik'hale tse ling, tse kang Pterostilbene. Le ha ho le joalo, ho ba bolokehileng, baetsi ba tlatsetso ba bangata ba khothaletsa ho boloka tšebeliso ea letsatsi le letsatsi ea NR pakeng tsa 250 ho isa ho 300 mg ka letsatsi.

 

Na Nicotinamide Riboside Chloride e Sireletsehile?

Liphuputso tse 'maloa tse entsoeng ho fihlela joale li fumane ts'ebeliso ea Nicotinamide Riboside ka har'a 1000 ho 2000 mg ka letsatsi e bolokehile bakeng sa ts'ebeliso ea batho. Leha ho le joalo, kaha ho hlokahala lithuto tse ngata tsa konkreite sebakeng sena, baetsi ba Nicotinamide Riboside ba khothaletsa ho boloka ho ja NR ea letsatsi le letsatsi tlasa 250-300 mg ka letsatsi.

Le ha ts'ebeliso ea Nicotinamide Riboside kapa Nicotinamide Riboside Chloride e bolokehile, e ka lebisa ho litla-morao tse kang ho nyekeloa ke pelo, ho tšoaroa ke hlooho, indigestion, mokhathala le letshollo. Haeba u ba le a mang a matšoao ana ha u ntse u nka tlatsetso ea NR, etela ngaka hang-hang. Ho feta moo, kaha ha ho na bopaki bo lekaneng mabapi le phello ea Nicotinamide Riboside ho basali ba baimana le ba anyesang, sehlopha sena se lokela ho ikhula ts'ebelisong ea litlatsetso tsa Nicotinamide Riboside. 

 

Nicotinamide Riboside chloride tlatsetsa

Haeba u batla meroho Nicotinamide Riboside chloride tlatsetsa, re khothaletsa tlatsetso ea Tru Niagen Nicotinamide Riboside. Tlatsetso ena e sebelisa NIAGEN, sehlahisoa se ngolisitsoeng ka molao sa k'hamphani ea NR. Khamphani ea tlhahiso e sebetsana feela le litlatsetso tsa Nicotinamide Riboside mme ka hona, motho a ka kholiseha hore litlatsetso tse entsoeng ke k'hamphani ke tsa boleng bo holimo haholo. Tru Niagen Nicotinamide Riboside supplement e tla ka li-capsules tse bonolo ho sebelisoa, tse bonolo ho li koenya. Basebedisi ba koptjoa ho nka capsule e le 'ngoe feela ka letsatsi.

Leha ho le joalo, haeba u batla gluten, lehe, BPA, linate, lithibelo le sehlahisoa se se nang lebese, re khothaletsa ho kenya chelete ea hau ho tlatsetso ea Thorne ResveraCel Nicotinamide Riboside. Tlatsetso ena e kopanya NR le flavonoids. Hammoho, tsena tse peli li ntlafatsa ts'ebetso ea sirtuin. Habohlokoa le ho feta, Thorne ResveraCel e re e etsa liteko tse 'ne tsa tlhatlhobo ho e ngoe le e ngoe ea tlatsetso ea eona mme ka hona, litlatsetso tsa k'hamphani li bolokehile hantle. Ho feta moo, litlatsetso tsena li hlahisoa setsing se netefalitsoeng sa cGMP United States le setsing se netefalitsoeng sa TGA se Australia.

Nicotinamide Riboside chloride

Ho Reka Nicotinamide Riboside chloride Powder ka bongata?

Tlhokahalo ea lisebelisoa tsa tlatsetso ea Nicotinamide Riboside e eketsehile haholo lilemong tse 'maloa tse fetileng, haholo hobane Nicotinamide Riboside e na le melemo e mengata. Haeba u batla ho fella 'marakeng oa tlatsetso oa li-Nicotinamide Riboside, ntho ea pele eo u lokelang ho e etsa ke ho iphumanela morekisi ea lisebelisoa tse tala oa ts'epo le tse tšepahalang. Moo u ka reka Nicotinamide Riboside chloride phofo ka bongata? Karabo ke Cofttek.

Cofttek ke mofani oa thepa ea lihlahisoa ea lihlahisoa tse qalileng ka 2008 mme ha ho fetile lilemo tse leshome feela, khamphani e thehile boteng ba eona linaheng tse 'maloa. Ntle le ho hlahisa lihlahisoa tse tšepahalang, k'hamphani e shebane le ho etsa tsoelo-pele lefapheng la biotechnology, theknoloji ea lik'hemik'hale le tlhahlobo ea lik'hemik'hale. Khamphani e boetse e ikemiselitse ho etsa lipatlisiso tsa boleng, e leng ho e fang moeli ho feta barekisi ba bang 'marakeng. The Phofo ea Nicotinamide Riboside Chloride  e fanweng ke khamphani e tla ka bongata ba 25 kgs mme e ka tshepeha boleng. Ho feta moo, k'hamphani e na le sehlopha se setle sa thekiso le tšehetso ea bareki se tla u hlokomela ka litlhoko tsohle tsa hau le lipotso ka nako ea nnete. Sena, haeba u batla ho reka phofo ea Nicotinamide Riboside Chloride ka bongata, tšepa Cofttek feela. 

 

References
  1. Conze, D., Brenner, C. & Kruger, CL Ts'ireletseho le Metabolism ea Tsamaiso ea Nako e Telele ea NIAGEN (Nicotinamide Riboside Chloride) ka Teko ea Kliniki e laoloang ka nako e sa lekanyetsoang, e habeli, e laoloang ke sebaka. Sci Rep9, 9772 (2019)
  2. Carlijn ME Remie, Kay HM Roumans, Michiel PB Moonen, Niels J Connell, Bas Haskes, Julian Mevenkamp, ​​Lucas Lindeboom, Vera HW de Wit, Tineke van de Weijer, Suzanne ABM Aarts, Esther Lutgens, Bauke V Schomaker, Hyung L Elfrink, Rubén Zapata-Pérez, Riekelt H Houtkooper, Johan Auwerx, Joris Hoeks, Vera B Schrauwen-Hinderling, Esther Phielier, Patrick Schrauwen, Nicotinamide riboside supplementation alters body complication and skeletal meskele acetylcarnitine concentrations in humans oles o phetseng hantle, American Journal of Clinical Nutrition, Buka ea 112, Taba ea 2, Phato 2020, maqephe a 413-426
  3. Elhassan, YS, Kluckova, K., Fletcher, RS, Schmidt, MS, Garten, A., Doig, CL, Cartwright, DM, Oakey, L., Burley, CV, Jenkinson, N., Wilson, M., Lucas , S., Akerman, I., Seabright, A., Lai, YC, Tennant, DA, Nightingale, P., Wallis, GA, Manolopoulos, KN, Brenner, C.,… Lavery, GG (2019). Li-Augotinamide Riboside Augions Mokhatlo oa Batho ba Tsofetseng oa Masapo NAD + Metabolome le li-Signature tsa Induces le li-Anti-inflammatory. Litlaleho tsa lisele28(7), 1717-1728.e6.
  4. Phofo ea Nicotinamide Riboside Chloride

 

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