Video ea OEA (111-58-0) video
OEA phofo Slitšobotsi
| Name: | Oleoylethanolamide (OEA) |
| CAS: | 111-58-0 |
| Ho hloeka | 98% |
| Limolek'hule Mokgwa wa ho Nahana: | C20H39NO2 |
| Boima ba limolek'hule: | 325.53 g / mol |
| Melt Point: | 59-60 ° C |
| Lebitso la k'hemik'hale | N-Oleoylethanolamide |
| Li-synonyms: | N-Oleoylethanolamine, N- (Hydroxyethyl) oleamide, N- (cis-9-Octadecenoyl) ethanolamine, OEA |
| InChI Key: | TLHOKOMELISO-MRVPVSSYSA-N |
| Halofo ea bophelo: | N / A |
| Solubility: | Soluble ho DMSO, Methanol, Metsi |
| Boemo ba ho Boloka: | 0 - 4 C bakeng sa nako e khuts'oane (matsatsi ho isa ho libeke), kapa -20 C nako e telele (likhoeli) |
| e sebetsa joang: | Oleoylethanolamide (OEA) ke metabolite ea tlhaho e entsoeng ka bongata bo fokolang ka mpeng ea hau e nyane. OEA e thusa ho laola tlala, boima, mafura a mmele le cholesterol ka ho tlama ho receptor e tsejoang e le PPAR-Alpha (Peroxisome proliferator-activated receptor alpha). |
| Ponahalo: | Pula e tšoeu |
Oleoylethanolamide (OEA) (111-58-0) Ponahalo ea NMR
Haeba o hloka COA, MSDS, HNMR bakeng sa sehlopha ka seng sa sehlahisoa le tlhaiso-leseling e ngoe, ka kopo ikopanye le rona mookameli oa papatso.
Oleoylethanolamide (OEA) CAS 111-58-0 ke eng?
Oleoylethanolamine (OEA) ke tlhaho e hlahang ka tlhaho ea ethanolamide le "receptor-activator" ea nyutlelie ea nyutlelie ea nyutlelie. E hlahisoa ka mpeng e nyane mme e thibela ho kenella ha lijo ka activation ea PPAR-α. OEA e boetse e kenya ts'ebetso ea GPR119, lipid e sebetsang hantle e nang le litlamorao tsa hypophagic le anti-obesity.
Melemo ea Oleoylethanolamide (OEA) CAS 111-58-0
Oleoylethanolamide (OEA) ke metabolite ea tlhaho e entsoeng ka bongata bo fokolang ka mpeng ea hau e nyane. OEA e thusa ho laola tlala, boima, mafura a mmele le cholesterol ka ho tlama ho receptor e tsejoang e le PPAR-Alpha (Peroxisome proliferator-activated receptor alpha). Ha e le hantle, OEA e eketsa metabolism ea mafura a 'mele mme e bolella kelello ea hau hore u tletse mme ke nako ea ho khaotsa ho ja. OEA e boetse e tsejoa ho eketsa litšenyehelo tsa khalori e sa amaneng le boikoetliso.
K'holejeng ea Oleoylethanolamide (OEA) CAS 111-58-0 Mokhoa oa ts'ebetso?
Oleoylethanolamide (OEA) e hlophisitsoe mme ea bokelloa ka maleng a manyane a haufi le a tsoang ho oleic acid e tsoang lijong, joalo ka oli ea mohloaare. Lijo tse nang le mafura a mangata li ka thibela tlhahiso ea OEA ka maleng. OEA e fokotsa ho ja lijo ka ho etsa homeostatic oxytocin le histamine brain circry hammoho le hedonic dopamine pathways. Ho na le bopaki ba hore OEA e kanna ea fokotsa matšoao a hedonic cannabinoid receptor 1 (CB1R), eo ts'ebetsong ea eona e amanang le keketseho ea ho ja lijo. OEA e fokotsa lipalangoang tsa lipid ho li-adipocyte ho fokotsa mafura. Ho hlakisoa ho eketsehileng ha litlamorao tsa OEA mabapi le phepelo ea lijo le metabolism ea lipid ho tla thusa ho khetholla mekhoa ea mmele e ka lebisoang ho nts'etsapele kalafo e sebetsang ea botena.
Oleoylethanolamide (OEA) ke agonist ea peroxisome proliferator-activated receptor-α (PPAR- α). N- Oleoylethanolamide e hlahisa lets'oao la mala le hlohlelletsang ts'ebetso e bohareng ea dopamine e theha khokahano lipakeng tsa balaoli ba caloric- homeostatic le hedonic- homeostatic. Oleoylethanolamide e kentsoe letsoho joalo ka ha mochini oa limolek'hule o amanang le katleho ea ho feta ka mpeng. N- Oleoylethanolamide ke khetho ea GPR55 agonist.
K'holejeng ea Oleoylethanolamide (OEA) CAS 111-58-0 kopo
Oleoylethanolamide (OEA) e sebetsa ho kenya tšebetsong ntho e bitsoang PPAR mme ka nako e ts'oanang e phahamisa ho chesa mafura le ho fokotsa polokelo ea mafura. Ha u ja, litekanyetso tsa OEA lia eketseha 'me takatso ea hau ea lijo ea fokotseha ha methapo ea kutlo e hokelang bokong ba hao e re e khotsofetse PPAR-α ke sehlopha sa li-ligand-activated nuclear receptor se kenang liphatseng tsa lefutso tsa lipid metabolism le energyhomeostasis pathways.
OEA phofo Ho rekisoa(Moo u ka rekang phofo ea Oleoylethanolamide (OEA) ka bongata)
Khamphani ea rona e thabela likamano tsa nako e telele le bareki ba rona hobane re tsepamisa maikutlo mosebetsing oa bareki le ho fana ka lihlahisoa tse ntle. Haeba o rata sehlahisoa sa rona, re feto-fetoha le maemo ka mokhoa oo re ratang ho odara ka oona o lekanang tlhoko ea hau le nako ea hau ea kapele ea li-odara e tiisa hore o tla latsoa sehlahisoa sa rona ka nako. Re shebile hape le lits'ebeletso tse kenyellelitsoeng boleng. Re fumaneha bakeng sa lipotso tsa ts'ebeletso le tlhaiso-leseling ho ts'ehetsa khoebo ea hau.
Re mofani oa phofo oa Oleoylethanolamide (OEA) ka lilemo tse 'maloa, re fana ka lihlahisoa ka theko ea tlholisano,' me sehlahisoa sa rona ke sa boleng bo holimo haholo 'me se etsoa liteko tse thata, tse ikemetseng ho netefatsa hore se bolokehile hore se ka sebelisoa lefatšeng ka bophara.
References
- Gaetani S, Oveisi F, Piomelli D (2003). "Ho feto-fetoha ha mokhoa oa lijo ka rat ke anorexic lipid mediator oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311-6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.
- Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Taolo ea ho ja lijo ka oleoylethanolamine". Sele. Mol. Bophelo Sci. 62 (6): 708-16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
- Gaetani S, Kaye WH, Cuomo V, Piomelli D (Loetse 2008). "Karolo ea li-endocannabinoids le tse tšoanang le tsona ho nona le mathata a ho ja". Ja Mathata a Boima ba 'mele. 13 (3): e42-8. PMID 19011363.
