Phofo ea NMN (1094-61-7) Moetsi le feme

Phofo ea NMN (1094-61-7)

April 7, 2020

Nicotinamide Mononucleotide, eo hape e tsejoang e le ("NMN" le "β-NMN") ke nucleotide e tsoang ho ribose le nicotinamide Joaloka nicotinamide riboside, NMN e tsoa ho niacin, mme batho ba na le li-enzyme tse ka sebelisang NMN ho hlahisa nicotinamide adenine dinucleotide ( NADH).

 


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 1kg / mokotla, 25kg / Drum

Phofo ea NMN (1094-61-7) tsa video

 

NMN phofo Slitšobotsi

Name: β-Nicotinamide Mononucleotide (NMN)
CAS: 1094-61-7
Ho hloeka 98%
Limolek'hule Mokgwa wa ho Nahana: C11H15N2O8P
Boima ba limolek'hule: 334.2208 g / mol
Melt Point: > 96 ° C
Lebitso la k'hemik'hale ((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate
Li-synonyms: Nicotinamide Mononucleotide; NMN; β-NMN; β-Nikotinamide mononucleotide
InChI Key: DAYLJWODMCOQEW-TURQNECASA-N
Halofo ea bophelo: N / A
Solubility: Soluble ho DMSO, Methanol, Metsi
Boemo ba ho Boloka: 0 - 4 C bakeng sa nako e khuts'oane (matsatsi ho isa ho libeke), kapa -20 C nako e telele (likhoeli)
e sebetsa joang: Nicotinamide mononucleotide (NMN) ke derivative ea B-vithamini niacin e ntlafatsang haholo bophelo bo botle le bophelo bo bolelele ka ho sebeletsa e le selelekela sa NAD +, komporo e bapala karolo ea bohlokoa tlhahisong ea matla, metabolism, le polelo ea gene 'meleng.
Ponahalo: Pula e tšoeu

 

Β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 ke eng?

Nicotinamide Mononucleotide, eo hape e tsejoang e le ("NMN" le "β-NMN") ke nucleotide e tsoang ho ribose le nicotinamide Joaloka nicotinamide riboside, NMN e tsoa ho niacin, mme batho ba na le li-enzyme tse ka sebelisang NMN ho hlahisa nicotinamide adenine dinucleotide ( NADH). Hobane NADH ke cofactor bakeng sa lits'ebetso kahare ho mitochondria, bakeng sa li-sirtuin, le bakeng sa PARP, NMN e ithutiloe ka mefuta ea liphoofolo e le sesebelisoa sa ho thibela le ho tsofala.

 

benefits-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 melemo

Patlisiso e khahlanong le botsofali e bonts'itse hore tlatsetso le NMN, senotlolo sa NAD + sa bohlokoa, e sebetsa hantle ho fokotseng ho theoha ha metabolism e amanang le lilemo le ho fokotsa tsoelo-pele ea maloetse a mangata a amanang le lilemo. NMN e na le litlamorao tse ntle tlhahisong ea matla maemong a seloko, e ntlafatsa mamello, e fokotsa tsitsipano, e thusa ho boloka tsamaiso ea potoloho, e lokisa DNA, 'me e na le litlamorao mosebetsing oa ho boloka matla a kelello. NMN e boetse e bonts'itse bokhoni ba ho ba moemeli oa kalafo khahlanong le mathata a neurodegenerative a tloaelehileng a botsofe. Tlatsetso le NMN e kanna ea u thusa ho boloka mamello le ho sisinyeha. Ho boloka mesebetsi ea lits'ebetso tsena tse fapaneng 'meleng ho khothaletsa bophelo bo botle le bophelo bo bolelele' me ho ntlafatsa boleng ba bophelo ha botsofali bo ntse bo tsoela pele.

 

β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 Mokhoa oa ts'ebetso?

β-Nicotinamide Mononucleotide (NMN) ke lipakeng tsa NAD + biosynthesis e hlahisoang ho tloha nicotinamide ka nicotinamide phosphoribosyltransferase (NAMPT) hape e bitsoang NMN kapa nicotinamide ribotide. Liphuputsong tsa morao-rao tsa lits'ebetso tsa NMN tsa thibelo le tlhahlobo ea mafu a itšetlehileng ka lilemo joalo ka lefu la tsoekere, lefu la methapo ea pelo, lefu la pelo jj, e se e le e 'ngoe ea li-biomarker tse chesang ka ho fetesisa moqoqong oa ho thibela botsofe morao tjena.

 

β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 kopo

β-Nicotinamide Mononucleotide (NMN) e na le litlamorao tse sebetsang tsa 'mele' meleng, ho kenyelletsa litholoana tse ntle ho mesifa ea marapo, ts'ebetso ea sebete, masapo a masapo, ts'ebetso ea mahlo, kutloisiso ea insulin, ts'ebetso ea 'mele ea ho itšireletsa mafung, boima ba' mele le maemo a ts'ebetso.

 

NMN phofo Ho rekisoa(U ka reka phofo ea β-Nicotinamide Mononucleotide (NMN) ka bongata)

Khamphani ea rona e thabela likamano tsa nako e telele le bareki ba rona hobane re tsepamisa maikutlo mosebetsing oa bareki le ho fana ka lihlahisoa tse ntle. Haeba o rata sehlahisoa sa rona, re feto-fetoha le maemo ka mokhoa oo re ratang ho odara ka oona o lekanang tlhoko ea hau le nako ea hau ea kapele ea li-odara e tiisa hore o tla latsoa sehlahisoa sa rona ka nako. Re shebile hape le lits'ebeletso tse kenyellelitsoeng boleng. Re fumaneha bakeng sa lipotso tsa ts'ebeletso le tlhaiso-leseling ho ts'ehetsa khoebo ea hau.

Re morekisi oa phofo ea β-Nicotinamide Mononucleotide (NMN) ka lilemo tse ngata, re fana ka lihlahisoa ka theko ea tlholisano, 'me sehlahisoa sa rona ke sa boleng bo holimo ebile sea hlahlojoa ka tieo, se ikemetseng ho netefatsa hore se bolokehile bakeng sa ts'ebeliso lefatšeng ka bophara.

 

References

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  • Lukacs M, Gilley J, Zhu Y, Orsomando G, Angeletti C, Liu J, Yang X, Park J, Hopkin RJ, Coleman MP, Zhai RG, Stottmann RW. Liphetoho tse matla tse lahlehang tsa biallelic-ho-tšebetso ho nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) ka li-fetus tse peli tse latellanang ka tatellano ea fetal akinesia. Neurol ea mehleng. 2019 Mots'eanong 25: 112961. Doi: 10.1016 / j.expneurol.2019.112961.PubMed PMID: 31136762.
  • Grozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K, Lei HC, Cunningham R, Sasaki Y, Migaud ME, Imai SI. Slc12a8 ke nicotinamide mononucleotide transporter. Nat Metab. 2019 Jan; 1 (1): 47-57. Doi: 10.1038 / s42255-018-0009-4. Epub 2019 Jan 7. PubMed PMID: 31131364; PubMed Central PMCID: PMC6530925.