Phofo ea NMN (1094-61-7) tsa video
NMN phofo Slitšobotsi
| Name: | β-Nicotinamide Mononucleotide (NMN) |
| CAS: | 1094-61-7 |
| Ho hloeka | 98% |
| Limolek'hule Mokgwa wa ho Nahana: | C11H15N2O8P |
| Boima ba limolek'hule: | 334.2208 g / mol |
| Melt Point: | > 96 ° C |
| Lebitso la k'hemik'hale | ((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate |
| Li-synonyms: | Nicotinamide mononucleotide; NMN; β-NMN; β-Nicotinamide mononucleotide |
| InChI Key: | DAYLJWODMCOQEW-TURQNECASA-N |
| Halofo ea bophelo: | N / A |
| Solubility: | Soluble ho DMSO, Methanol, Metsi |
| Boemo ba ho Boloka: | 0 - 4 C bakeng sa nako e khuts'oane (matsatsi ho isa ho libeke), kapa -20 C nako e telele (likhoeli) |
| e sebetsa joang: | Nicotinamide mononucleotide (NMN) ke e nkiloeng ho B-vitamin niacin e ntlafatsang bophelo bo botle le bophelo bo bolelele haholo ka ho sebetsa e le selelekela sa NAD+, motsoako o bapalang karolo ea bohlokoa matleng. Tlhahiso, metabolism, le liphatsa tsa lefutso 'meleng. |
| Ponahalo: | Pula e tšoeu |
NMN (1094-61-7) Ponahalo ea NMR
Haeba o hloka COA, MSDS, HNMR bakeng sa sehlopha ka seng sa sehlahisoa le tlhaiso-leseling e ngoe, ka kopo ikopanye le rona mookameli oa papatso.
Β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 ke eng?
Nicotinamide Mononucleotide, eo hape e tsejoang e le (“NMN” le “β-NMN”) ke nucleotide e nkiloeng ho ribose le nicotinamide Like nicotinamide riboside, NMN ke motsoako oa niacin, 'me batho ba na le li-enzyme tse ka sebelisang NMN ho hlahisa nicotinamide adenine dinucleotide (NADH). Hobane NADH ke cofactor bakeng sa lits'ebetso tse ka hare ho mitochondria, bakeng sa li-sirtuin, le bakeng sa PARP, NMN e 'nile ea ithutoa ka mehlala ea liphoofolo e le ntho e ka' nang ea e-ba moemeli oa methapo ea kutlo le e khahlanong le botsofali.
benefits-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 melemo
Patlisiso e khahlanong le botsofali e bonts'itse hore tlatsetso ka NMN, e leng NAD+ ea bohareng, e sebetsa hantle ho fokotsa ho fokotseha ho amanang le botsofali le ho liehisa tsoelo-pele ea mafu a mangata a amanang le botsofali. NMN e na le liphello tse molemo tlhahisong ea matla boemong ba lisele, e ntlafatsa mamello ea tsoekere, e fokotsa ho ruruha, e thusa ho boloka tsamaiso ea potoloho ea mali, ho lokisa DNA, 'me e na le liphello tse molemo ho boloka ts'ebetso ea kelello. NMN e boetse e bonts'itse bokhoni ba ho ba moemeli oa kalafo khahlanong le mathata a neurodegenerative a tloaelehileng a botsofali. Ho tlatselletsa le NMN ho ka ba molemo ka ho baballa mamello le motsamao. Ho boloka mesebetsi ea mekhoa ena e fapaneng ho pholletsa le 'mele ho khothalletsa bophelo bo botle le bophelo bo bolelele le ho ntlafatsa haholo boleng ba bophelo ha botsofali bo ntse bo tsoela pele.
β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 Mokhoa oa ts'ebetso?
β-Nicotinamide Mononucleotide (NMN) ke lipakeng tsa NAD + biosynthesis e hlahisoang ho tloha nicotinamide ka nicotinamide phosphoribosyltransferase (NAMPT) hape e bitsoang NMN kapa nicotinamide ribotide. Liphuputsong tsa morao-rao tsa lits'ebetso tsa NMN tsa thibelo le tlhahlobo ea mafu a itšetlehileng ka lilemo joalo ka lefu la tsoekere, lefu la methapo ea pelo, lefu la pelo jj, e se e le e 'ngoe ea li-biomarker tse chesang ka ho fetesisa moqoqong oa ho thibela botsofe morao tjena.
β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 kopo
β-Nicotinamide Mononucleotide (NMN) e na le litlamorao tse sebetsang tsa 'mele' meleng, ho kenyelletsa litholoana tse ntle ho mesifa ea marapo, ts'ebetso ea sebete, masapo a masapo, ts'ebetso ea mahlo, kutloisiso ea insulin, ts'ebetso ea 'mele ea ho itšireletsa mafung, boima ba' mele le maemo a ts'ebetso.
NMN phofo Ho rekisoa(U ka reka phofo ea β-Nicotinamide Mononucleotide (NMN) ka bongata)
Khamphani ea rona e thabela likamano tsa nako e telele le bareki ba rona hobane re tsepamisa maikutlo mosebetsing oa bareki le ho fana ka lihlahisoa tse ntle. Haeba o rata sehlahisoa sa rona, re feto-fetoha le maemo ka mokhoa oo re ratang ho odara ka oona o lekanang tlhoko ea hau le nako ea hau ea kapele ea li-odara e tiisa hore o tla latsoa sehlahisoa sa rona ka nako. Re shebile hape le lits'ebeletso tse kenyellelitsoeng boleng. Re fumaneha bakeng sa lipotso tsa ts'ebeletso le tlhaiso-leseling ho ts'ehetsa khoebo ea hau.
Re morekisi oa phofo ea β-Nicotinamide Mononucleotide (NMN) ka lilemo tse ngata, re fana ka lihlahisoa ka theko ea tlholisano, 'me sehlahisoa sa rona ke sa boleng bo holimo ebile sea hlahlojoa ka tieo, se ikemetseng ho netefatsa hore se bolokehile bakeng sa ts'ebeliso lefatšeng ka bophara.
References
- Kiss T, Balasubramanian P, Valcarcel-Ares MN, Tarantini S, Yabluchanskiy A, Csipo T, Lipecz A, Reglodi D, Zhang XA, Bari F, Farkas E, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) kalafo e bontša khatello ea maikutlo le ho pholosa bokhoni ba angiogenic liseleng tse tsofetseng tsa "cerebromicrovascular endothelial": mochini o ka thusang ho thibela ho senyeha ha methapo ea kutlo. Geroscience. 2019 Mots'eanong 29. doi: 10.1007 / s11357-019-00074-2. PubMed PMID: 31144244.
- Lukacs M, Gilley J, Zhu Y, Orsomando G, Angeletti C, Liu J, Yang X, Park J, Hopkin RJ, Coleman MP, Zhai RG, Stottmann RW. Liphetoho tse matla tse lahlehang tsa biallelic-ho-tšebetso ho nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) ka li-fetus tse peli tse latellanang ka tatellano ea fetal akinesia. Neurol ea mehleng. 2019 Mots'eanong 25: 112961. Doi: 10.1016 / j.expneurol.2019.112961.PubMed PMID: 31136762.
- Grozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K, Lei HC, Cunningham R, Sasaki Y, Migaud ME, Imai SI. Slc12a8 ke nicotinamide mononucleotide transporter. Nat Metab. 2019 Jan; 1 (1): 47-57. Doi: 10.1038 / s42255-018-0009-4. Epub 2019 Jan 7. PubMed PMID: 31131364; PubMed Central PMCID: PMC6530925.
