Alpha Lipoic Acid (ALA)

April 20, 2021

Cofttek ke moetsi oa phofo ea Alpha Lipoic Acid (ALA) ea Chaena. Fektheri ea rona e na le sistimi e felletseng ea taolo ea tlhahiso (ISO9001 & ISO14001), e nang le tlhahiso ea khoeli le khoeli ea 1000kg.

 


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 1kg / mokotla, 25kg / Drum

Alpha Lipoic Acid (ALA) (1077-28-7) Slitšobotsi

Name: Alpha Lipoic Acid (ALA)
CAS: 1077-28-7
Ho hloeka 98%
Limolek'hule Mokgwa wa ho Nahana: C8H14O2S2
Boima ba limolek'hule: 206.33 g / mol
Melt Point: 60-62 ° C (140-144 ° F; 333-335 K)
Lebitso la k'hemik'hale (R) -5- (1,2-Dithiolan-3-yl) pentanoic acid;

α-Lipoic acid; Alpha lipoic acid; Thioctic acid e; 6,8-Dithiooctanoic acid

Li-synonyms: (±) -cy-Lipoic acid, (±) -1,2-Dithiolane-3-pentanoic acid, 6,8-Dithiooctanoic acid, DL -α-Lipoic acid, DL -6,8-Thioctic acid, Lip (S2 )
InChI Key: AGBQKNBQESQNJD-UHFFFAOYSA-N
Halofo ea bophelo: Halofo ea bophelo ea ALA e tsamaisoang ka molomo ke metsotso e 30 feela
Solubility: E qhibiliha hanyane haholo ka metsing (0.24 g / L); Ho qhibiliha ha ethanol 50 mg / mL
Boemo ba ho Boloka: 0 - 4 C bakeng sa nako e khuts'oane (matsatsi ho isa ho libeke), kapa -20 C nako e telele (likhoeli)
e sebetsa joang: Alpha-lipoic acid e sebelisoa 'meleng ho senya lik'habohaedreite le ho etsa matla bakeng sa litho tse ling tsa' mele. Alpha-lipoic acid e bonahala e sebetsa joalo ka antioxidant, ho bolelang hore e ka fana ka ts'ireletso bokong tlasa maemo a ts'enyo kapa kotsi.
Ponahalo: Makhalase a mosehla a kang nale

 

Alpha Lipoic Acid (ALA) (1077-28-7) Ponahalo ea NMR

 

Alpha Lipoic Acid (ALA) (1077-28-7) - NMR Spectrum

Haeba o hloka COA, MSDS, HNMR bakeng sa sehlopha ka seng sa sehlahisoa le tlhaiso-leseling e ngoe, ka kopo ikopanye le rona mookameli oa papatso.

 

Alpha Lipoic Acid (ALA) (1077-28-7)?

Alpha-lipoic acid ke motsoako o fumanoang ka tlhaho kahare ho sele e ngoe le e ngoe ea 'mele oa motho. Karolo ea eona ea mantlha ke ho fetola tsoekere ea mali (tsoekere) hore e be matla a sebelisa oksijene, ts'ebetso e bitsoang metabolism ea aerobic. Alpha-lipoic acid e boetse e nkuoa e le antioxidant, ho bolelang hore e ka fokotsa metsoako e kotsi e bitsoang li-radical tse sa lefelloeng tse senyang lisele tsa lefutso.

Se etsang hore alpha-lipoic acid e ikhethile ke hore e qhibiliha ka metsing le mafura. Seo se bolela hore e ka fana ka matla hanghang kapa ea e boloka bakeng sa ts'ebeliso ea nako e tlang.

Alpha-lipoic acid e ka boela ea sebelisa li-antioxidants "tse sebelisitsoeng", ho kenyeletsoa vithamine C, vithamine E, le motsoako o matla oa amino acid o tsejoang ka hore ke glutathione.1 Nako le nako ha li-antioxidants li fokotsa matla a mahala, li a tsitsisa ebe li fetoha mahala. Alpha-lipoic acid e thusa ho li khutlisa ka ho monya lielektrone tse ngata le ho li fetolela mokokotlong ho sebopeho sa tsona se tsitsitseng.

Alpha-lipoic acid ka linako tse ling e nkuoa e le tlatsetso tlasa mohopolo e ka ntlafatsa ts'ebetso e itseng ea metabolic, ho kenyelletsa ho chesa mafura, tlhahiso ea collagen le taolo ea tsoekere ea mali. Ho na le bopaki bo ntseng bo hola ba bonyane tse ling tsa lipolelo tsena.

 

Alpha Lipoic Acid (ALA) (1077-28-7) melemo

lefu la tsoekere

Ke khale ho nahanoa hore alpha-lipoic acid e ka thusa ho laola tsoekere ka ho eketsa lebelo leo tsoekere ea mali e kopantsoeng ka lona. Sena se ka thusa kalafong ea lefu la tsoekere, lefu le khetholloang ka maemo a phahameng a tsoekere ea mali.

Tlhahlobo ea 2018 e hlophisitsoeng le tlhahlobo ea litlhahlobo tsa liteko tse 20 tse laoloang ka linako tse ling tsa batho ba nang le ts'oaetso ea ts'oaetso (ba bang ba na le lefu la tsoekere la mofuta oa 2, ba bang ba na le mathata a mang a ts'ebetsong) ba fumane hore tlatsetso ea lipoic acid e theotse ho itima lijo tsoekere ea mali, khatello ea insulin, ho hanyetsa insulin le mali a hemoglobin Maemo a A1C.

 

Bohloko ba Meroho

Neuropathy ke lentsoe la bongaka le sebelisetsoang ho hlalosa bohloko, ho ba shohlo, le maikutlo a sa tloaelehang a bakoang ke tšenyo ea methapo. Khafetsa tšenyo e bakoa ke khatello ea mali e behiloeng methapong ke mafu a sa foleng a kang lefu la tsoekere, lefu la Lyme, lefu la shingles, lefu la qoqotho, ho hloleha ha liphio le HIV.

Ba bang ba lumela hore alpha-lipoic acid, e fanoang ka litekanyetso tse lekaneng, e ka loants'a khatello ena ka ho etsa tšebetso e matla ea antioxidant. Ho bile le bopaki ba phello ena ho batho ba nang le lefu la tsoekere la lefu la tsoekere, e leng boemo bo ka fokolisang batho ba nang le lefu la tsoekere le tsoetseng pele.

Tlhahlobo ea 2012 ea lithuto tse tsoang Netherlands e fihletse qeto ea hore letsatsi le leng le le leng methapo ea methapo ea 600-mg ea alpha-lipoic acid e fuoang nako e fetang libeke tse tharo e fane ka "phokotso e kholo le e nepahetseng ea bongaka ho bohloko ba methapo."

Joalo ka lithuto tsa pele tsa lefu la tsoekere, li-alpha-lipoic acid tse tlatsetsang li ne li sa sebetse hantle kapa li se na phello ho hang.

 

Bohloko ba ho Shoeloa Weight

Bokhoni ba alpha-lipoic acid ba ho ntlafatsa khalori e tukang le ho khothaletsa ho theola boima ba 'mele bo fetellelitsoe ke litsebi tse ngata tsa phepo le baetsi ba litlatsetso. Ha ho buuoa joalo, ho na le bopaki bo ntseng bo hola ba hore alpha-lipoic acid e ka ama boima, leha e le ka boikokobetso.

Tlhahlobo ea 2017 ea lithuto tse tsoang Univesithing ea Yale e fumane hore alpha-lipoic acid e tlatsetsa, ho tloha tekanyong ho tloha ho 300 ho isa ho 1,800 mg letsatsi le leng le le leng, e thusitse ho baka boima ba boima ba boima ba liponto tsa 2.8 ha bo bapisoa le placebo.

Ho ne ho se na kamano lipakeng tsa alpha-lipoic supplement dose le palo ea boima ba 'mele. Ho feta moo, nako ea kalafo e bonahala e susumetsa boima ba 'mele oa motho (BMI), empa eseng boima ba' mele ba motho.

Seo se bolelang ke hore, ha ho ntse ho bonahala o ka theola boima ba 'mele ka alpha-lipoic acid,' mele oa hau o ka ntlafala ha mafura a nkeloa sebaka ke mesifa e omeletseng.

 

Cholesterol e phahameng

Haesale ho lumeloa hore alpha-lipoic acid e susumetsa boima ba 'mele le bophelo bo botle ka ho fetola sebopeho sa mafura maling. Sena se kenyelletsa ho eketsa "cholesterol" ea "high" e nang le "high" high-density lipoprotein (HDL) ha e ntse e theola "cholesterol" le "triglycerides" tse mpe. Liphuputso tsa morao-rao li bontša hore ho kanna ha se be joalo.

Phuputsong ea 2011 e tsoang Korea, batho ba baholo ba 180 ba fane ka 1,200 ho isa ho 1,800 mg ea alpha-lipoic acid e lahlile boima ba liperesente tse 21 ho feta sehlopha sa placebo kamora libeke tse 20 empa e se na ntlafatso ho k'holeseterole e felletseng, LDL, HDL, kapa triglycerides.

Ebile, litekanyo tse phahameng tsa alpha-lipoic acid li fuoe keketseho ea k'holeseterole e felletseng le LDL ho bankakarolo ba boithuto.

 

Letlalo le Senyehileng Letsatsing

Baetsi ba litlolo hangata ba rata ho ithorisa ka hore lihlahisoa tsa bona li rua molemo ho "anti-aging" ea alpha-lipoic acid. Patlisiso e fana ka maikutlo a hore ho kanna ha ba le bopaki bo itseng ba lipolelo tsena. Sengoloa sa tlhahlobo se bolela hore ke antioxidant e matla ebile e ithutiloe ka litlamorao tsa eona tsa ts'ireletso khahlano le tšenyo ea radiation.

 

Alpha Lipoic Acid (ALA) (1077-28-7) sebelisa khanya?

Alpha-lipoic acid kapa ALA ke ntho e etsahalang ka tlhaho 'meleng. E sebetsa mesebetsi ea bohlokoa maemong a lisele, joalo ka tlhahiso ea matla. Hafeela u ntse u phetse hantle, 'mele o ka hlahisa ALA eohle eo e e hlokang molemong oa tsena. Leha ho le joalo, ho bile le tjantjello e ngata ea haufinyane ea ho sebelisa tlatsetso ea ALA. Babuelli ba ALA ba etsa lipolelo tse fapaneng le litlamorao tsa ho phekola maemo a kang lefu la tsoekere le HIV ho matlafatsa tahlehelo ea boima ba 'mele.

 

Alpha Lipoic Acid (ALA) (1077-28-7) Tekanyo

Le ha e nkuoa e bolokehile, ha ho na tataiso e tataisang ts'ebeliso e nepahetseng ea alpha-lipoic acid. Boholo ba litlatsetso tsa molomo bo rekisoa ka mefuta ho tloha 100 ho isa ho 600 mg. Ho ipapisitsoe le bongata ba bopaki ba hajoale, ho nahanoa hore tekanyetso e phahameng ea letsatsi le letsatsi ea ho fihla ho 1,800 mg e bolokehile ho batho ba baholo.

Ha ho buuoa joalo, ntho e ngoe le e ngoe ho tloha boima ba 'mele le lilemo ho isa tšebetsong ea sebete le ts'ebetso ea liphio e ka ama se sireletsehileng ho uena u le motho ka mong. E le molao o akaretsang oa monoana o motona, etsa phoso ka lehlakoreng la tlhokomeliso 'me kamehla o khethe tekanyetso e tlase.

Alpha lipoic acid e tlatsetsa e ka fumanoa marang-rang le mabenkeleng a mangata a lijo le mabenkeleng a lithethefatsi. Bakeng sa ho monya haholo, litlatsetso li lokela ho nooa ka mpeng e se nang letho.

 

Alpha-lipoic Acid phofo Ho rekisoa(Moo u ka rekang phofo ea Alpha-lipoic Acid ka bongata)

Khamphani ea rona e thabela likamano tsa nako e telele le bareki ba rona hobane re tsepamisa maikutlo mosebetsing oa bareki le ho fana ka lihlahisoa tse ntle. Haeba o rata sehlahisoa sa rona, re feto-fetoha le maemo ka mokhoa oo re ratang ho odara ka oona o lekanang tlhoko ea hau le nako ea hau ea kapele ea li-odara e tiisa hore o tla latsoa sehlahisoa sa rona ka nako. Re shebile hape le lits'ebeletso tse kenyellelitsoeng boleng. Re fumaneha bakeng sa lipotso tsa ts'ebeletso le tlhaiso-leseling ho ts'ehetsa khoebo ea hau.

Re setsebi sa mofani oa phofo ea Alpha-lipoic Acid ka lilemo tse 'maloa, re fana ka lihlahisoa ka theko ea tlholisano,' me sehlahisoa sa rona ke sa boleng bo holimo haholo 'me se etsoa liteko tse thata, tse ikemetseng ho netefatsa hore se bolokehile hore se ka sebelisoa lefatšeng ka bophara.

 

References

  1. Haenen, GRMM; Bast, A (1991). "Ho qhekella ha acid e hypochlorous ka lipoic acid". Likhemik'hale Pharmacology. 42 (11): 2244-6. doi: 10.1016 / 0006-2952 (91) 90363-A. PMID 1659823.
  2. Biewenga, GP; Haenen, GR; Bast, A (Loetse 1997). "Pharmacology ea antioxidant lipoic acid". Kakaretso ea Pharmacology. 29 (3): 315-31. doi: 10.1016 / S0306-3623 (96) 00474-0. PMID 9378235.
  3. Schupke, H; Hempel, R; Peter, G; Hermann, R; et al. (Phuptjane 2001). "Litsela tse ncha tsa metabolism tsa alpha-lipoic acid". Metabolism ea Lithethefatsi le Boikutlo. 29 (6): 855-62. PMID 11353754.
  4. Acker, DS; Wayne, WJ (1957). "E sebetsang hantle le e ntšang mahlaseli a kotsi α-lipoic acid". Litaba tsa American Chemical Society. 79 (24): 6483-6487. doi: 10.1021 / ja01581a033.
  5. Hornberger, CS; Heitmiller, RF; Gunsalus, IC; Schnakenberg, GHF; et al. (1952). "Litokisetso tsa maiketsetso tsa lipoic acid". Tlaleho ea American Chemical Society. EA-74 (9): 2382. doi: 10.1021 / ja01129a511.