KHOPOLO RADICAL MAHALA

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Metabolism e tloaelehileng ea 'mele

Tšilafalo ea moea

Mahlaseli a kotsi a ultraviolet

Tšilafalo ea tšepe e boima

Tšilafalo ea likokoanyana

Tšilafalo ea likokoanyana

 

 

RADICALS & MAFU A MAHALA

 

Ka tloaelo, li-radical tse sa lefelloeng lia hlokahala bakeng sa 'mele, empa li-radicals tse fetelletseng tse sa lefelloeng li ka baka ho se leka-lekane ha ts'ebetso ea mmele, ebe li lebisa khatellong ea mali e tsoang malwetseng a fapaneng (lingoloa li supa hore li-radicals tsa mahala ke mohloli oa mafu a fapaneng).

 

 

 

 

LIEKETSENG MOTLATSI

 

'Mele ea rona e ke ke ea sebetsa ntle le oksijene,' me hang ha palo e kholo ea li-radicals e se e eketsehile, 'mele o tlasa khatello ea maikutlo o tla etsa hore sistimi ea tokiso e hlolehe ho tlosa li-radical tse fetelletseng tsa mahala. Maemong a ikhethang, 'mele o hloka ho tlatsa li-antioxidants in vitro ho tlosa li-radical tse fetelletseng tsa mahala.

 

NTS'ELISO LITSIETSI

 

 

L-ERGOTHIONEINE –KHETHO E NCHA EA MOTSOALLE OA TLHAHO

 

EGT ke chiral ea tlhaho ea amino-acid antioxidant biosynthesized ho libaktheria tse ling le li-fungus. Ke motsoako oa bohlokoa oa li-bioactive o sebelisitsoeng e le mohokahanyi o matla, sehlaseli sa mahlaseli a kotsi, taolo ea liphetoho tsa phokotso ea khase le bioenergetics ea cellular, le cytoprotector ea 'mele, jj.
L-Ergothioneine (EGT, ERGO, CAS: 497-30-3), eo hape a tsejoang ka hore ke (S) -cy-Carboxy-2,3-dihydro-N, N, N-trimethyl-2-thioxo-1H-imidazole- 4-ethanaminium letsoai le kahare, le qalile ho nts'oa ergot ke Tanret C ka 1909, joale le lona le ile la fumanoa maling a phoofolo. Pure EGT ke kristale e tšoeu, e qhibilihang ka metsing, (e qhibilihile 0.9mol / L ka mocheso oa kamore). Autoxidation e ke ke ea hlaha ka boleng ba 'mele oa pH kapa tharollo e matla ea alkaline. EGT e ka ba teng ka mefuta e 'meli ea isomer - foromo ea thiol le thione, joalo ka ha ho bonts'itsoe ka tlase:

 

 

 

LIEKETSENG MOTLATSI

Ka melemo ea mesebetsi e mengata, EGT e hlahella har'a li-antioxidants tse ling tse ngata.

 

 

menyetla

Ka melemo ea mesebetsi e mengata, EGT e hlahella har'a tse ling tse ngata antioxidantsMelemo (ha e bapisoa le glutathione, cysteine ​​jj.):
——EGT ho bonolo ho bokellana liseleng 'me ho tsepamisa mohopolo ho tsitsitse ho feta li-antioxidants tse ling.
——EGT e sebetsa hantle haholo ho fokotsa ho shoa ha lisele ho bakoang ke pyrogallol.
-EEGT haholo-holo e hlasela ROS ho thibela oxidation, ha glutathione le ba bang ba hlasela li-radicals tsa mahala, ke hore, tse ling antioxidants scavenge lihlahisoa tsa oxidation.(1) Oleoylethanolamide (oea) - leqhubu la boloi la bophelo ba hau

HO FIHLELA BONOLO

Results: EGT e ne e le 'muelli ea mafolofolo ka ho fetesisa oa li-radicals tsa mahala ha a bapisoa le li-antioxidants tsa khale joaloka GSH, uric acid le trolox. Haholo-holo, matla a phahameng ka ho fetisisa a antioxidant a bonts'itsoeng ke EGT vs peroxyl radicals a hlahisitse 25% e phahame ho feta boleng bo fumanoeng ka reference antioxidant trolox. Bokhoni ba ho qhekella ba EGT bo lebisang ho li-radical hydroxyl bo ne bo phahame ka 60%, ha bo bapisoa le uric acid, e emelang antioxidant vs. hydroxyl radicals. Kamora nako, EGT e bonts'itse tšebetso e phahameng ka ho fetisisa ea antioxidant hape e lebisang ho peroxynitrite, e nang le matla a ho senya 10% e phahameng ho feta a uric acid.

 

 

 

MESEBETSI E MANG

 

EGT e boetse e na le litlamorao taolong ea matla a kenang,

ho matlafatsa boits'ireletso,

ho ntlafatsa sekhahla sa pholo ea setho,

Ho sireletsa sebete ho tsoa likotsi,

ho thibela ho ruruha,

ho fetoha ha methapo,

bofokoli ba nts'etsopele le lefu la koluoa.

 

 

BOHLOKOA NTS'ETSO

① LEBAKA LE FUMANEHILE KA BOPHARA MEMENG LE DIPHOOFOLO

 

TAELO

5-10mg yuniti bakeng sa motho e moholo le li-unit tse 2-3 tse kenang khafetsa li bohlokoa lijong tsa hau tsa letsatsi le letsatsi.

Mohloli: Li Yiqun, Zhou Nianbo. Mesebetsi ea Biology le Likopo tsa EGT [J]. Lijo tsa Boenjiniere, 2010 li9 （3） ： 26-28.

Lihlahisoa li thathamisitsoe ka tsela e latelang:

Bana (lilemo tse 3-11) ≤l 0 mg / letsatsi
Bocha (Lilemo tse 11-21) ≤30 mg / letsatsi
Batho ba baholo (lilemo tse 21-80) ≤30 mg / letsatsi

Tlhokomeliso: 1. Litekanyo tsa bana le batho ba baholo years lilemo tse 3 -80）

           Ts'ebeliso ea basali ba baimana kapa ba anyesang ha e khothalletsoe.

Mohloli oa litaba: Tetrahedron ha o etsa kopo ea US NDI

Lintlha li fana ka maikutlo a: 10.5mg / g bakeng sa OXIS's ADI (Kamohelo e Amohelehang ea Letsatsi le Letsatsi).

 

③ TS'ENISO

 

 

KEKETSO LE KOPO

(1) KEKETSO

Hajoale, ho na le mekhoa e meraro ea tlhahiso ea EGT: tsa tlhaho bio-ntšang (haholo-holo e tsoa ho li-mushroom, lisele tsa liphoofolo le ho ntša mali), le mokhoa oa biosynthesis.

Papiso ea Tlatsetso ea EGT mekhoa

(2) KOPO

EGT e na le lits'ebetso tse pharaletseng ho litlolo, lijo tse sebetsang, meriana, litlhare, biomedicine, joalo-joalo.

(3) Likopo tse ling tse fumanehang

References

  1. Oleoylethanolamide (oea) - leqhubu la boloi la bophelo ba hau
  2. Anandamide vs cbd: ke efe e molemo bakeng sa bophelo bo botle ba hau? Tsohle tseo o hlokang ho li tseba ka bona!
  3. Ntho e ngoe le e ngoe eo u hlokang ho e tseba ka nicotinamide riboside chloride
  4. Lisebelisoa tsa Magnesium l-threonate: melemo, litekanyo le litla-morao
  5. Palmitoylethanolamide (erekisi): melemo, litekanyetso li behoa, tšebeliso, tlatsetsa
  6. Melemo e 6 e holimo ea bophelo bo botle ea litlatsetso tsa resveratrol
  7. Melemo e meholo e mehlano ea ho nka phosphatidylserine (ps)
  8. Melemo e meholo e mehlano ea ho nka pyrroloquinoline quinone (pqq)
  9. Molemo ka ho fetisisa nootropic tlatsetsa ea alpha gpc
  10. Tlatsetso ea nicotinamide mononucleotide (nmn) e molemohali ho thibela botsofali

 

Sengoloa ke: Dr. Zeng

Sehlooho ka:

Ngaka Zeng

Mothehi-motheo, boetapele ba tsamaiso ea mantlha ea k'hamphani; PhD e amohetse Univesithing ea Fudan ka k'hemistri ea manyolo. Ho ba le boiphihlelo bo fetang lilemo tse robong ho chemistry ea tlhaho le moralo oa lithethefatsi; lipampiri tse ka bang 10 tsa lipatlisiso tse phatlalalitsoeng likoranteng tse nang le matla, tse nang le litokelo tse fetang tse hlano tsa China.

 

Tse ka Hare