Noopept (157115-85-0) Slitšobotsi
| Name: | Noopept |
| CAS: | 157115-85-0 |
| Ho hloeka | 98% |
| Limolek'hule Mokgwa wa ho Nahana: | C17H22N2O4 |
| Boima ba limolek'hule: | 318.37 g / moll |
| Melt Point: | 94.0 ho 98.0 ° C |
| Lebitso la k'hemik'hale | ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate |
| Li-synonyms: | Noopept; ethyl 2 - [[((2S) -1- (2-phenylacetyl) pyrrolidine-2-carbonyl] amino] acetate; N- (1- (Phenylacetyl) -L-prolyl) glycine ethyl ester; Ethyl 1- (phenylacetyl ) -L-prolylglycinate; phofo ea noopept; Nootropic GVS-111; (S) -ethyl 2- (1- (2-phenylacetyl) pyrrolidine-2-carboxaMido) acetate; SGS 111 |
| InChI Key: | PJNSMUBMSNAEEN-AWEZNQCLSA-N |
| Halofo ea bophelo: | Noopept half-life ke metsotso e 60 ho isa ho e 90 feela, ho bolelang hore motho ea tloaelehileng a ka sebetsa halofo ea lethal dose ka nako eo. |
| Solubility: | E qhibiliha ka DMSO (25 mg / ml) |
| Boemo ba ho Boloka: | 0 - 4 C bakeng sa nako e khuts'oane (matsatsi ho isa ho libeke), kapa -20 C nako e telele (likhoeli) |
| e sebetsa joang: | Noopept ke e ratoang temoho-ntlafatso tlatsetso ka nootropic sechaba. Lithuto tsa batho li bonts'itse litholoana tse ts'episang, ka ts'ebeliso e ka bang teng kalafong ea lefu la Alzheimer's. |
| Ponahalo: | e tsoeu e le hore e be phofo ea beige |
ke eng Noopept (157115-85-0)?
Noopept ke lebitso la N-phenylacetyl-L-prolylglycine ethyl ester; motsoako oa maiketsetso oa nootropic hangata ho thoeng ka phoso ke karolo ea sehlopha sa racetam sa nootropics (ha e na khubung ea 2-oxo-pyrollidine kahoo ha se racetam). Russia, moo Noopept e qalileng ho etsoa, ka linako tse ling e bitsoa GSV-111.
Noopept e entsoe ka 1996. Sebopeho sa eona se ipapisitse le cycloprolylglycine; neuropeptide e sa feleng. Cycloprolylglycine e tsejoa e le ho khothaletsa polelo ea Brain Derives Neurotrophic Factor bokong. Bafuputsi ka hona ba hlahisa hore nootropic e thehiloeng ho cycloprolylglycine e tla ba le litlamorao tse ts'oanang, mme ke sona se boleloang ka Noopept.
Le ha e se racetam, Noopept e ts'oana hantle le Piracetam. Noopept ha e le hantle ke conjugate ea dipeptide ea Piracetam. Ho boleloa hore limolek'hule tse peli li na le litlamorao tse ts'oanang, ha Noopept e le eona e matla ho feta li-nootropics tse peli ka boima.
Melemo ea Noopept (157115-85-0)
Melemo e amanang le Noopept e pharaletse ebile e fapane. Sena ha se makatse hobane se ka hlahisa acetylcholine hape sa eketsa maemo a NGF le BDNF.
Mona ke lenane la melemo e atisang ho amahanngoa le Noopept:
- Khopotso e ntlafalitsoeng mosebetsi
- Tlhokomelo e ntlafetseng, ho tsepamisa maikutlo le ho tsepamisa mohopolo
- Ho tsoha ho eketsehileng
- E khothalletsa methapo ea pelo le kholo ea lisele tse ncha tsa boko
- E fokotsa khatello ea mali mme e khothaletsa bophelo bo botle ba boko
- E fokotsa matšoenyeho mme e khothaletsa thabo
Litholoana tsena kaofela li ka bakoa ke ho eketseha ha linomoro tsa acetylcholine receptor mokokotlong oa methapo ea kutlo le ho eketseha ha maemo a NGF / BDNF ka nako e telele. Phello eo ho phahamisa neuropeptide ho nang le ts'oaetso e kholo, mme litlamorao tsa nakoana tsa acetylcholine li ka bonahala. Phello e kopaneng ea mekhoa ena e 'meli e tla ba ntlafatso e phethahetseng ea boko, ka karolo e ngoe le e ngoe ea ts'ebetso ea boko e ntlafalitsoe ka tsela e itseng.
Noopept (157115-85-0) e sebelisa?
Noopept ke tlatsetso e tsebahalang e matlafatsang mohopolo sechabeng sa nootropic. Noopept e sebelisoa haholoholo bakeng sa ho eketsa lets'oao la acetylcholine, ho eketsa polelo ea BDNF le NGF, ho sireletsa ho chefo ea glutamate, le ho eketsa ts'oaetso ea methapo bokong. Tsena ke mekhoa ea ts'ebetso ea ts'ebetso e thehiloeng lithutong tsa pele ho nako.
Noopept (157115-85-0) Tekanyo
Ho khetha li-noopept ho ka ferekanya, haholo-holo ho ba qalang, empa mona ke tataiso e potlakileng le e bonolo ea ho u thusa.
Hopola, ha Noopept hangata e bapisoa le Piracetam, e hlile e fihlile makhetlo a 1000 ho feta Piracetam!
Le hore o ile a re, se ke sebelisa e tšoanang le hore u ne u tla ka tloaelo etsa le Piracetam kapa esita le tse ling tse nootropics le tšoanang liphello.
E le molao o akaretsang, o lokela ho jala tekanyetso e le 'ngoe ho pholletsa le letsatsi mme o phomole kamora likhoeli tse ling le tse ling tse peli molemong oa polokeho.
- Palo ea molomo
Tekanyo e khothalletsoang ea motho e moholo ke 10-30 mg, ho latela boima ba 'mele oa hau. Leha ho le joalo, kamehla ho molemo ho qala ka 10 mg feela ho lekola phello ea 'mele oa hau.
Ntle le moo, o ka eketsa lethal dose hamorao.
Li-capsules li na le boholo bo fapaneng, ka hona etsa bonnete ba hore o sheba leibole hantle pele o reka botlolo.
Nka feela bonyane bonyane boo u bo hlokang bakeng sa polokeho ea hau. Sena se tla u thusa ho u thibela ho haha mamello ea lithethefatsi.
- Tekanyo ea lipuo tse ling
Bakeng sa litekanyo tsa lipuo tse ling, o lokela ho qala hanyane ka hanyane, ho 5 mg.
Kaha e na le liphetho tse potlakileng hape tse matla, o lokela ho hlokomela hore na o itšoara joang ka mokhoa ona pele o eketseha ho ea tekanyong ea 10 mg.
Ho bohlokoa haholo ho lekanya ka nepo palo ea phofo eo u e hlokang. Meriana e phahameng e ka lebisa ho Noopept e nang le mathata ditlamorao, kahoo e-ba hlokolosi haholoanyane!
- Ho foka Phofo Tekanyo
Joalo ka litekanyo tsa lipuo tse nyane, ho noa litekanyetso tsa phofo e lokela ho ba tlase haholo.
Le ha ka kakaretso ho bolokehile ho noa 10-30 mg ka mokhoa o fe kapa o fe, Noopept e ka baka hlooho, mokhathala le ho nyekeloa ke pelo, kahoo lula u le tseleng ea tlhokomeliso.
- Megadose
Haeba tekanyetso e tloaelehileng e le limiligrama tse 10 ho isa ho tse 30, Noopept megadose ke 50 milligrams e otlang. Batho ba bang ba bile ba nka chelete e fetang 100 mg!
Megadose e sebelisoa ha u batla ho bona ntho e makatsang ntlafatso mohopolong oa hau, ho ithuta, bohlale, le tsebo ea kelello ka kakaretso.
Sena se lokela ho etsoa hang feela ka beke haholo, kaha ts'ebeliso e tsoelang pele e ka etsa hore e se sebetse hantle nakong e telele.
Ntle le moo, sena se ka ba kotsi haholo ho batho ba bang, ka hona etsa bonnete ba hore o tseba boemo ba hau ba mamello pele o leka sena.
Phofo ea Noopept Ho rekisoa (Moo u ka rekang phofo ea Noopept ka bongata)
Khamphani ea rona e natefeloa ke likamano tsa nako e telele le bareki ba rona hobane re tsepamisa maikutlo ho bareki tšebeletso le ho fana ka lihlahisoa tse kholo. Haeba u thahasella sehlahisoa sa rona, re tenyetseha le mokhoa oa ho etsa litaelo tse lumellanang le tlhoko ea hau e khethehileng le nako ea rona ea ho etella pele ka kotara ho tiisa hore u tla latsoa sehlahisoa sa rona ka nako. Re tsepamisa maikutlo hape ho lits'ebeletso tse eketsoang boleng. Re fumaneha bakeng sa lipotso tsa ts'ebeletso le tlhaiso-leseling ho ts'ehetsa khoebo ea hau.
Re setsebi Phofo ea Noopept mofani oa thepa ka lilemo tse 'maloa, re fana ka lihlahisoa ka theko ea tlholisano,' me sehlahisoa sa rona ke sa boleng bo holimo 'me se etsoa liteko tse thata, tse ikemetseng ho netefatsa hore li bolokehile hore li ka sebelisoa lefatšeng ka bophara.
References
[1] Ostrovskaya RU, Gudasheva TA, Zaplina AP, Vahitova JV, Salimgareeva MH, Jamidanov RS, Seredenin SB. Noopept e susumetsa polelo ea NGF le BDNF ho rat hippocampus. Bull Exp Biol Med. 2008 Sep; 146 (3): 334-7. doi: 10.1007 / s10517-008-0297-x. PMID: 19240853.
[2] Neznamov GG, Teleshova ES. Papiso lithuto tsa Noopept le piracetam kalafo ea bakuli ba nang le bothata ba kelello bo bobebe ho mafu a boko a vascular le a sithabetsang. Neurosci Behav Physiol. 2009 Mar;39(3):311-21. doi: 10.1007/s11055-009-9128-4. PMID: 19234797.
[3] Murzina, GB, Pivovarov, AS Modulation of the Acetylcholine-Induction Input Current ke Noopept ho Helix Lucorum Neurons. BIOPHYSICS 64, 393-399 (2019).
[4] Neznamov, GG; Teleshova, ES (2009). "Lithuto tsa papiso ea Noopept le piracetam kalafong ea bakuli ba nang le mathata a bonolo a ho tseba likelello tsa maloetse a bokong a methapo le a sithabetsang". Neuroscience le Physiology ea Boitšoaro. 39 (3): 311--321.
[5] Tardner, P (2020). "Ho fumana litekanyetso tse nepahetseng bakeng sa moemeli oa nootropic Noopept: Tlhahlobo ea lingoliloeng tse fumanehang" (PDF). Koranta ea Machabeng ea Saense ea Tikoloho le Theknoloji.
