Pyridoxal hydrochloride (65-22-5)

Pyridoxal hydrochloride (65-22-5) Slitšobotsi

Pyridoxal hydrochloride (65-22-5) Ponahalo ea NMR

Haeba o hloka COA, MSDS, HNMR bakeng sa sehlopha ka seng sa sehlahisoa le tlhaiso-leseling e ngoe, ka kopo ikopanye le rona mookameli oa papatso.

Pyridoxal Hydrochloride ke eng?

Pyridoxal hydrochloride ke mofuta oa vithamine B6. E le mofuta oa 4-carbaldehyde ea vithamine B6, e entsoe ka ho kopanya pyridoxal le molar e lekanang le hydrochloric acid. Ke tlatsetso ea phepo e nepahetseng. Foromo ea eona ea lik'hemik'hale ke C8H10ClNO3. Lebitso la eona la IUPAC ke 3-hydroxy-5-(hydroxymethyl) -2-methyl pyridine-4-carbaldehyde hydrochloride.

Ntho ena ke ea sehlopha sa organic compound se bitsoang pyridoxal le lihlahisoa tsa eona. Tsena li na le karolo ea pyridoxal e nang le selikalikoe sa pyridine se nang le libaka tse ling tse fapaneng. Lintlha tsena tse nkang sebaka li kenyelletsa sehlopha sa methyl se boemong ba 2, sehlopha sa hydroxyl se boemong ba 3, sehlopha sa carbaldehyde se boemong ba 4, le sehlopha sa hydroxymethyl se boemong ba 5.

Pyridoxal hydrochloride e sebelisoa ho phekola lefu la tsoekere la nephropathy. Hoa hlokahala ho boloka bophelo bo botle ba methapo, letlalo, le lisele tse khubelu tsa mali. E sebelisoa ke 'mele ho etsa li-neurotransmitters tse kang serotonin le norepinephrine. E boetse e thusa ho etsa sphingolipids le aminolevulinic acid. Pyridoxal hydrochloride e fetoloa ho pyridoxal 5-phosphate, coenzyme bakeng sa ho kopanya li-amino acid.

Kaha vithamine B6 ha e khone ho hlahisoa ke 'mele e hloka ho jeoa ho tsoa mehloling e fapaneng kapa ka li-supplement. E fumaneha ka mefuta e mengata e 'ngoe ea tsona ke pyridoxal e leng mofuta oa 4-carboxaldehyde oa vithamine B6 hape ke cofactor bakeng sa mesebetsi e mengata ea metabolic.

Pyridoxal hydrochloride ke mofuta oa letsoai oa pyridoxal 'me o fetoha habonolo ho pyridoxal phosphate eo hape e tsejoang ka hore ke PLP kamora tsamaiso mme e sebetsa joalo ka coenzyme bakeng sa ts'ebetso ea metabolic.

Pyridoxal Hydrochloride e sebetsa joang?

Vithamine B6 e na le mefuta e meraro ka tlhaho: pyridoxine, pyridoxal, le pyridoxamine, tseo kaofela li fetohang sebopeho sa tsona se sebetsang 'meleng mme li bitsoa pyridoxal 5'-phosphate. Matšoao a khaello ea vithamine B6 ke seborrheic dermatitis, microcytic anemia, glossitis, convulsions, peripheral neuropathy, depression, joalo-joalo Vithamine B6 e boetse e le ho phekola overdose ea isoniazid, chefo ea bohata ea morel mushroom, ho pepeseha ha hydrazine, joalo-joalo Pyridoxal hydrochloride e ka sebetsa e le tlatsetso. ho tlatsa vithamine B6 'meleng.

Pyridoxal hydrochloride ke selelekela sa pyridoxal 5'- phosphate. Kamora ho sebelisa pyridoxal hydrochloride, e fetoha pyridoxal 5-phosphate ka har'a hepatocytes le lisele tsa mucosal tsa mala. E ntan'o nkoa ke mali 'me e ajoa ho pholletsa le' mele. E ameha mefuteng e mengata ea karabelo ea metabolic. Sena se kenyelletsa sebopeho le metabolism ea li-amino acid le glycogen. E ka boela ea thusa ho kopanya li-nucleic acid, hemoglobin, le li-neurotransmitters.

Pyridoxal 5'-phosphate ke coenzyme e amehang ho metabolism ea amino acid. E sebetsa joalo ka coenzyme liketsong tsohle tsa transamination. E boetse e ameha ho oxidation le deamination reaction ea amino acid.

Sehlopha sa aldehyde se teng ka pyridoxal 5'-phosphate se theha kamano ea Schiff-base le sehlopha sa epsilon-amino sa sehlopha se itseng sa lysine sa li-enzyme tsa aminotransferase. Sehlopha sa alpha-amino sa substrate ea amino acid joale se tlosa sehlopha sa epsilon-amino. Sena se fella ka hore ho thehoe adimine, e senyehang. Kamora sena, e fetoha quinoid mahareng e amohelang protons maemong a fapaneng mme qetellong e fetoha ketimine. Ketimine ebe e fumana hydrolyzed e le hore sehlopha sa amino se lule se le protheine.

Pyridoxal hydrochloride e boetse e thusa ho kopanya li-neurotransmitters tse kang serotonin, dopamine, norepinephrine, le gamma-aminobutyric acid.

Pyridoxal hydrochloride ha e so amoheloe hore e sebelisoe ke FDA hajoale.

Synthesis

Pyridoxal hydrochloride e entsoe ho tsoa karabelong ea manyolo ka ho arabela pyridoxamine ka molar e le 'ngoe ea hydrochloric acid. Pyridoxal hydrochloride e ka boela ea etsoa ka ho khetha oxidation. Karabelo e kenyelletsa ho nka pyridoxine hydrochloride e le sesebelisoa sa ho qala mme mokhoa oa catalytic oxidation o ne o tla etsoa ka metsing. Catalytic oxidation e kenyelletsa mohloli oa oksijene, mokelikeli, letsoai la inorganic le amine ligand. Sehlahisoa sa ho qetela sa catalytic oxidation e ka ba pyridoxal hydrochloride.

Pharmacokinetics ea Pyridoxal Hydrochloride

Ho ikhethela: Li honoa habonolo ke phallo e sa sebetseng, 'me ho monya ha tsona hangata ho fumaneha liseleng tsa mala a mala tse nang le pyridoxine kinase le pyridoxal phosphate.

Metabolism: Bongata ba metsoako ena ea lintho tse phelang e nkoa ke sebete 'me ho kenngoa ha eona ho etsoa ka ho arola ka har'a mojari le ho tšoasa metabolism e le metsoako ea phosphate. Phosphorylation ea metsoako e etsahala habonolo sebeteng.

Phatlalatso: Phosphate ea mahala ea pyridoxal sebeteng e tšeloa ka hydrolyzed ho pyridoxal, eo hamorao e romelloang kantle ho naha ebe e tlama ho hemoglobin le albin ka har'a erythrocyte. Karolo ea dephosphorylated e siea sele ka ho phatlalla, ka hona ho ne ho tla ba le pokello e nyane ea pyridoxal phosphate liseleng.

Mantle: Pyridoxal ea mahala e setseng sebeteng e kenngoa ka potlako ho 4-pyridoxic acid 'me ke eona sehlahisoa se ka sehloohong sa excretory ea motsoako. Oxidation ho 4-pyridoxic acid e kopanngoa ke aldehyde dehydrogenase, e fumanehang ka bongata liseleng tse ngata, oxidation e boetse e etsoa ke renal le hepatic aldehyde oxidase enzymes. Tsela ea bohlokoa ea ho ntša pyridoxal hydrochloride ka mor'a metabolism ke ka moroto.

Melemo ea Pyridoxal Hydrochloride

Ho na le lisebelisoa tse 'maloa tsa pyridoxal hydrochloride. Leha ho le joalo, boholo ba litšebeliso tsena li ntse li le tlas'a lipatlisiso 'me li ke ke tsa nkoa e le litšebeliso tse hlakileng tsa motsoako ona.

Mona ke tse ling tsa melemo ea pyridoxal hydrochloride

Phello ho Diabetes Nephropathy

Sephetho sa sehlahisoa sa Pyridoxal hydrochloride pyridoxal 5'-phosphate se ka thibela ho thehoa ha lihlahisoa tse tsoetseng pele tsa glycation (AGEs). E etsa sena ka ho ts'oara 3-deoxyglucosone. Phuputsong e entsoeng ka likhoto tse nang le lefu la tsoekere la streptozotocin, li ile tsa phekoloa ka pyridoxal 5-phosphate bakeng sa libeke tse 16 [1]. Liphello li bontšitse ho fokotseha ho hoholo ha albuminuria, glomerular hypertrophy, katoloso ea mesangial, le interstitial fibrosis. E boetse e fokotsa maemo a AGE. Kahoo, ha nako e ntse e ea, pyridoxal hydrochloride e ka fokotsa nephropathy e hlahang lefung la tsoekere.

E sebetsa joalo ka Metabolite

Pyridoxal hydrochloride le pyrimidine 5'-phosphate li sebetsa e le lintho tsa bohlokoa tse hlokahalang nakong ea karabelo ea metabolic. Bokhoni ba bona ba ho sebetsa joalo ka coenzyme bo hlokoa ka bobeli 'mele oa motho hammoho le likokoana-hloko tse sa tšoaneng le libaktheria tse kang Escherichia coli, Saccharomyces cerevisiae, litoeba. Li hlokahala ho hlahisa metsoako e sa tšoaneng e hlokahalang 'meleng.

Phello ho Neurotransmitters

Pyridoxal hydrochloride e ka thusa ho etsa li-neurotransmitters tse fapaneng 'meleng.

Phello ea Phokolo ea mali

Libakeng tse ling tsa phokolo ea mali, vithamine B6 ea hlokahala ho fana ka eona e le tlatsetso. Pyridoxal hydrochloride e ka thusa ho fana ka pyridoxal 5'-phosphate e hlokahalang ho phekola maemo a joalo.

Sebelisa Lipatlisisong Tsa Bongaka

Pyridoxal 5'-phosphate, motsoako o hlahisoang ke pyridoxal hydrochloride, oa hlokahala bakeng sa libaktheria tse ling tse amanang le bongaka. Ke ho netefatsa kholo ea bona e nepahetseng. E kenyelletsa libaktheria tse kang Granulicatella le Abiotrophia [2]. Tlhokahalo ea phepo ea pyridoxal hydrochloride e ka baka moetlo oa kholo ea satellite ho libaktheria tsena. In vitro culture, libaktheria tsena li ka hola feela libakeng tseo ho nang le libaktheria tse ling tse etsang pyridoxal. E 'ngoe ea lintlha tsa mantlha mabapi le motsoako oa pyridoxal ke hore e kanna ea ba e bile karabelo ea khale ka ho fetesisa ea aerobic metabolism lefatšeng.

Litlamorao tsa Pyridoxal Hydrochloride

• Ho halefa ha letlalo
• Hypersensitivity
• Ho kgena ka ho hema
• Nausea
• Ho otla
• Pheliso ea meriana ea mafu
• Boikutlo bo fokotsehileng
• Hlooho ea hlooho
• Boitšoaro
• Ho bapala
• Mathata a ferekane

Litšebelisano tsa Pyridoxal Hydrochloride le Lithethefatsi tse ling

Ha ho na tlhahisoleseling e lekaneng mabapi le tšebelisano e tobileng ea pyridoxal hydrochloride le lithethefatsi tse ling. Leha ho le joalo, ho na le tlhahisoleseling e tsebahalang mabapi le tšebelisano ea eona ea motsoako oa pyridoxal 5'-phosphate le meriana e meng.

Tse ling tsa likamano tsena ke:

Amiodarone - Ha e sebelisana le pyridoxine 5'-phosphate, e ka eketsa kutloisiso ea leseli, ea baka ho chesoa ke letsatsi, joalo-joalo.

Phenytoin - Pyridoxine 5'-phosphate e ka eketsa metabolism ea phenytoin 'meleng, e bakang katleho e fokolang ea ho qetela.

Phenobarbital - Pyridoxine 5'-phosphate e ka eketsa nako ea ho senyeha ha phenobarbital.

Levodopa - E ka baka metabolism e potlakileng ea levodopa.

Leha khaello ea pyridoxine e tsejoa hore e etsahala nakong ea kemaro le ho anyesa, ha ho na tlhahisoleseding mabapi le liphello ea pyridoxal hydrochloride maemong ana. Kahoo, ho kgothaletswa ho ba hlokolosi.

U ka Reka kae Pyridoxal Hydrochloride ka 2021?

U ka reka phofo ea pyridoxal hydrochloride ka ho toba ho tloha k'hamphani ea moetsi oa pyridoxal hydrochloride. E fumaneha ka bongata ba 1kg ka mokotla kapa 15kg ka moropa. Leha ho le joalo, sena se ka fetoloa ho latela litlhoko tsa mosebelisi. Phofo ena e hloka ho bolokoa mocheso oa 0 ho isa ho 4 ° bakeng sa nako e khuts'oane le ho -20 °C nako e telele.

Pyridoxal hydrochloride powder e fumaneha ka mokhoa o mosoeu kapa o mosoeu o mosoeu. E entsoe ka lisebelisoa tse ntle ka ho fetisisa tlas'a tlhokomelo e tiileng ho netefatsa hore basebelisi ba fumana sehlahisoa se setle ka ho fetisisa.

References

1. Nakamura, S., Li, H., Adijiang, A., Pischetsrieder, M., & Niwa, T. (2007). Pyridoxal phosphate e thibela tsoelo-pele ea lefu la tsoekere. Nephrology Dialysis Transplantation, 22(8), 2165-2174.
2. Kitada, K., Okada, Y., Kanamoto, T., & Inoue, M. (2000). Thepa ea serological ea mefuta ea Abiotrophia le Granulicatella (e fapaneng ka phepo e nepahetseng streptococci). Microbiology le immunology, 44(12), 981-985.

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