Palmitoylethanolamide (PEA) phofo

April 7, 2020

Cofttek ke moetsi oa phofo ea Palmitoylethanolamide (PEA) Chaena. Fektheri ea rona e na le sistimi e felletseng ea taolo ea tlhahiso (ISO9001 & ISO14001), e nang le tlhahiso ea khoeli le khoeli ea 3200kg.

 


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 1kg / mokotla, 25kg / Drum

Pale ea video ea Palmitoylethanolamide (PEA) (544-31-0)

 

Palmitoylethanolamide (PEA) phofo Slitšobotsi

 

Name: Palmitoylethanolamide (PEA)
CAS: 544-31-0
Ho hloeka 98% Micronized PEA ; 98% phofo
Limolek'hule Mokgwa wa ho Nahana: C18H37NO2
Boima ba limolek'hule: 299.49 g / mol
Melt Point: 93 ho 98 ° C
Lebitso la k'hemik'hale Hydroxyethylpalmitamide Palmidrol N-Palmitoylethanolamine Palmitylethanolamide
Li-synonyms: Palmitoylethanolamide

Palmidrol

N- (2-Hydroxyethyl) hexadecanamide

N-Palmitoylethanolamine

InChI Key: HXYVTAGFYLMHSO-UHFFFAOYSA-N
Halofo ea bophelo: dihora tse 8
Solubility: Soluble ho DMSO, Methanol, Metsi
Boemo ba ho Boloka: 0 - 4 C bakeng sa nako e khuts'oane (matsatsi ho isa ho libeke), kapa -20 C nako e telele (likhoeli)
e sebetsa joang: Palmitoylethanolamide (PEA) ke ba lelapa la endocannabinoid, sehlopha sa li-amide acid tse mafura. PEA e netefalitsoe hore e na le ts'ebetso ea analgesic le anti-inflammatory mme e sebelisitsoe lithutong tse 'maloa tse laoloang tse lebisitsoeng ho taolo ea bohloko bo sa foleng ho bakuli ba baholo ba nang le maemo a fapaneng a tlasa khatello ea kliniki.
Ponahalo: Pula e tšoeu

 

Palmitoylethanolamide (544-31-0) Ponahalo ea NMR

Palmitoylethanolamide (544-31-0) - NMR Spectrum

Haeba o hloka COA, MSDS, HNMR bakeng sa sehlopha ka seng sa sehlahisoa le tlhaiso-leseling e ngoe, ka kopo ikopanye le rona mookameli oa papatso.

 

Palmitoylethanolamide ke endogenic fatty acid amide e oelang tlasa sehlopha sa Nuclear Factor Agonists. Ka tlhaho e hlaha lijong tse kang soya, matokomane a lecithin le 'mele oa motho.

Palmitoylethanolamide e fumanoe ka lekhetlo la pele li-1940 tsa pele. Bo-rasaense ba fumane pele hore ts'ebeliso ea lehe le phofshoana le phofshoana e khothaletsa karabelo e ntle ea boits'ireletso ho bana mme ea fokotsa menyetla ea ho ba le rheumatic fever. Liphuputso tse ling li fihletse qeto ea hore li-yolk tsa mahe li na le motsoako o khethehileng ke hore, PEA. PEA e boetse e fumanoe lijong tse felletseng joalo ka linate le soya, tse thusang ho fana ka ts'ireletso e matla le melemo ea bophelo bo botle.

Ntle le ho fumanoa lijong tse ling, PEA e boetse e etsahala 'meleng oa rona ka tlhaho. K'hemik'hale e hlahisoa 'meleng oa rona ke lisele tsa rona tse ngata e le karolo ea karabelo e ntle ea boits'ireletso ba mmele. PEA e entsoe ka ho khetheha ke 'mele ea rona ho arabela ho ruruha. Ho tsebahala ho sebetsana le bohloko ba rona 'meleng ka ho sireletsa sesole sa rona sa' mele hore se se itšoare ka tsela e fetelletseng mme se khothaletsa boits'oaro bo botle ba mmele le boits'ireletso 'meleng.

Palmitoylethanolamide phofo e sebelisoa haholo joalo ka moriana oa bohloko, fibromyalgia, bohloko ba methapo, multiple sclerosis, carpal tunnel syndrome, le maemo a mang a mangata.

 

Palmitoylethanolamide le Lelapa la Cannabinoid

Palmitoylethanolamide ha se hakaalo hore e tsoa ho cannabis empa e ka nkuoa e le karolo ea lelapa la li-cannabinoid. PEA e sebetsa ka tsela e ts'oanang haholo le CBD (cannabidiol), e leng e 'ngoe ea metsoako e meholo ea kannete empa ha e na litlamorao tsa kelello. Lihlahisoa tsa CBD li ratoa haholo matsatsing ana 'me li fumaneha hoo e batlang e le ho tsohle ho tloha ho lioli ho ea ho litlolo le lihlahisoa tsa lijo. Lihlahisoa tsa CBD li boetse li sebelisetsoa melemo e mengata ea bophelo bo botle, ho kenyeletsoa kelello, methapo ea kutlo le bophelo bo kopaneng.

PEA le eona ke cannabinoid, empa e hlahlojoa e le qetellongcannabinoid joalo ka ha e entsoe kahare ho mmele. Leha ho le joalo, e fapane le cannabidiol le tetrahydrocannabinol kaha 'mele ha o etse lik'hemik'hale tsena ka tlhaho.

 

Mokhoa oa Khato

Palmitoylethanolamide e baka mafura a chesa mafura, a matlafatsang le a khahlanong le ho ruruha. Ha liprotheine tsena tsa bohlokoa li qala ho ts'oaroa, PEA e emisa ts'ebetso ea liphatsa tsa lefutso tse khonang ho khothaletsa ho ruruha le ho fokotsa tlhahiso ea lintho tse 'maloa tsa ho ruruha. PEA e boetse e fokotsa ts'ebetso ea lefutso la FAAH le senyang tlhaho cannabinoid anandamide mme e eketsa maemo a anandamide 'meleng. Anandamide e ikarabella ho fokotsa bohloko ba hau, ho khutsisa likelello tsa hau le ho khothaletsa boikhathollo 'meleng oa hau.

PEA e boetse e tsejoa e tlama lisele tsa 'mele le ho fokotsa bohloko le ho ruruha. E na le asiti ea palema ka sebopeho sa eona, e thusang 'mele ho etsa Palmitoylethanolamide' meleng.

Ho ea ka bo-rasaense ba bang, ho eketsa feela ho noa acid ea palmitic ho ke ke ha ama tlhahiso ea PEA. Lebaka ke hore 'mele oa hau o tla sebelisa PEA feela' meleng oa hau ha feela o hloka ho folisa ho ruruha kapa bohloko ba hau. Sena se fella ka maemo a PEA 'meleng ka tloaelo a fapana ho pholletsa le letsatsi.

Tsela e molemohali ea ho fumana melemo ea PEA ke ka ho ja lijo tse nang le PEA kapa li-supplement tse tloaelehileng.

 

Palmitoylethanolamide phofo melemo le likopo

PEA e netefalitsoe hore e na le thepa ea ho kokobetsa bohloko le e khahlanong le ho ruruha mme e sebeliselitsoe taolo ea bohloko bo sa foleng har'a batho ba baholo ba nang le maemo a mangata a tlholeho. Mohlala, e ka fana ka phello e thusang joalo ka thuso ea kalafo ea mahlaba a bohloko ba morao ho bakuli ba baholo kapa e ka sebelisoa e le mong bakeng sa taolo ea bohloko bo sa foleng ho bakuli ba kulang haholo sebakeng sa li-analgesics tsa setso tse nang le kotsi e kholo ea litlamorao.

Liphetho tse ts'episang li bonts'itsoe kalafong ea li-radiculopathies tse sa sebetseng tse nang le tlhahiso e nyane ea mica ea PEA le kalafo e kopaneng le alpha-lipoic acid ho fokotsa lefu le sa foleng la prostatitis / chronic pelvic pain syndrome.

Ka tlase ke melemo e meng e meholo ea PEA:

 

· Thuso ea Bohloko

Ho na le bopaki bo netefatsang bokhoni ba PEA ba ho fokotsa bohloko bo boholo. PEA e 'nile ea batlisisoa ho batho ba fetang likete tse 6 le liteko tsa bongaka tsa 30 ho tloha lilemong tsa bo-1070. Leha ho le joalo, hangata thuto e hlotsoe ho khetholla pakeng tsa bohloko ba methapo le bo seng ba methapo. The melemo ea Palmitoylethanolamide hobane bohloko ba methapo ha bo hlake hantle ka lebaka la tlhaiso-leseling e sa lekaneng ho fihlela joale.

Thibelo e 'ngoe e ne e le hore boholo ba lithuto tsena li ne li sena taolo ea placebo mme lipatlisiso tsa boleng bo holimo li hlokahala ho etsa qeto ea katleho ea PEA ho feliseng mefuta e fapaneng ea bohloko.

Phuputsong ea lithuto tsa batho tse 12, litlatsetso tsa PEA li bonts'itse katleho ho fokotsa bohloko bo sa foleng le bo bohloko ba pelo ntle le litlamorao tse mpe. Batho bao ba 12 ka tloaelo ba ne ba fuoa litlatsetso tsa PEA ka litekanyetso pakeng tsa 200 le 1200 mg / letsatsi bakeng sa libeke tse fetang 3 ho isa ho tse 8. Tlatsetso e nkile hoo e ka bang libeke tse peli ho fihlela boemo ba ho imolla bohloko. Ho e nka nako e telele ho matlafalitse litlamorao ntle le ho baka litlamorao.

Phuputso e 'ngoe e entsoeng ka 300 kapa 600 mg / letsatsi la PEA e bonts'itse phokotso e matla ea bohloko ba sciatica tekong ea bohlokoahali ea batho ba fetang 600. PEA e fokotsa bohloko ka 50% ka libeke tse 3 feela, tse sa fihlelleheng ka li-painkillers tse ngata.

 

· Bophelo bo botle ba 'mele le nchafatso

PEA e boetse e tsejoa e le molemo bakeng sa mafu a methapo ea pelo le stroke. Tlatsetso e bonoa e ntlafatsa ts'ebetso ea boko ka ho thusa lisele tsa boko ho phela le ho fokotsa ho ruruha.

Phuputsong ea bakuli ba 250 ba nang le stroke, sebopeho sa PEA le luteolin se bonts'itse matšoao a ntlafatso ea ho fola. E phatlalatsoa hape hore e na le phello e ntle ho bophelo bo botle ba boko, boiphihlelo ba ts'ebeliso ea kelello le ts'ebetso ea letsatsi le letsatsi ea boko. Liphetho li ile tsa bonahala kamora matsatsi a 30 a tlatsetso mme ha kamora likhoeli tse peli tsa tlatsetso, ntlafatso e eketsehileng e ile ea hlokomeloa.

Ka bobeli li na le luteolin hape, PEA e ile ea bonoa e thibela lefu la Parkinson ho litoeba ha li sebelisoa le luteolin. E fokotsa tšenyo bokong ka ho sireletsa methapo ea kutlo ea dopamine. Leha ho le joalo, ho hlokahala lithuto tse tloaelehileng tsa bongaka ho netefatsa liphuputso tsena.

Phuputso e 'ngoe e bontšitse hore PEA e nang le luteolin e thusitse ho ntlafatsa maemo a neurotrophic joalo ka BDNF & NGF e leng liprotheine tse nyane tse matla tse thusang ho theha lisele tse ncha tsa boko. E ntlafalitse bokhoni ba boko ba ho nchafatsa lisele le lisele tse ncha kamora ho senyeha ho bohloko mokokotlong kapa bokong. Ha PEA hammoho le luteolin e ne e sebelisoa ho litoeba e ne e ntlafatsa pholiso ea methapo ea litoeba tse nang le likotsi tsa mokokotlo.

Ka lebaka la ketsahalo ea tlhaho ea li-cannabinoids ho PEA, litlamorao li bonts'a ntlafatso boitšoarong ba bakuli, maikutlong. E bontšitse kotsi e fokotsehileng ea ho inkela litoeba. Leha ho le joalo, litlamorao tsa ona tsa ho ts'oaroa li ntse li lokela ho batlisisoa bathong mme lithuto tse ling lia hlokahala ho netefatsa sena.

 

· Liphello Pelong

Lefu la pelo le hlaha ka lebaka la ho thijoa ha methapo ea mali e lebisang pelong. PEA e tsejoa ho hlaphoheloa tšenyo ea lisele tsa pelo le ho eketsa phallo ea mali ho ea pelong e thusang ho fokotsa linyeoe tsa lefu la pelo. Phuputso e entsoeng ka litoeba e boetse e bonts'a ho theoha hoa maemo a ts'oaetso a cytokine lipelong.

Ts'ebeliso ea PEA le eona e fokolitse boemo ba khatello e phahameng ea mali ho likhoto le ho thibela tšenyo ea liphio ka ho fokotsa lintho tse ruruhang. Ka ho fokotsa methapo ea mali, PEA e ne e sebetsa hantle ho thibela li-enzyme le li-receptor tse eketsang khatello ea mali.

 

· Matšoao a khatello ea maikutlo

Phuputsong ea haufinyane, batho ba 58 ba nang le khatello ea maikutlo ba ile ba alafshoa ka PEA. Tekanyo ea 1.2 gm ka letsatsi e ile ea fuoa bakuli ka libeke tse fetang 6. Sena se felletse ka ntlafatso e potlakileng ea maikutlo le matšoao a akaretsang. PEA ha e kenyelletsoa pheko ea ho imeloa kelellong, ke hore, citalopram, e theola matšoao a khatello ea maikutlo ka 50% e tloaelehileng.

 

· Matšoao a sefuba se tloaelehileng

Phuputso e 'ngoe e bontšitse PEA ho ba pheko e sebetsang ea ho loants'a vaerase ea ntaramane e bakang sefuba. Lipatlisisong tse ling tsa pejana tsa batho ba fetang likete tse 4, PEA e ile ea khona ho bonahatsa tšusumetso e ntle ho boits'ireletso 'me ea thusa ho fokotsa matšoao a kang a ntaramane ho bakuli.

Phuputsong e 'ngoe, masole a bacha a 900 a ile a fuoa hoo e ka bang 1,200 mg ea PEA e ileng ea fokotsa nako ea serame le ho folisa matšoao a kang' metso, nko ea mokokotlo, feberu le hlooho.

 

· Ho ruruha hoa mala

Qetellong PEA e sebelisitsoe ka katleho ho hlasimolla matšoao a lefu la ho ruruha ha mala (IBS) liphoofolong. Lisebelisoa tsa PEA ha li lekoa ho litoeba tse nang le ho ruruha ho sa foleng ha mala, li thusitse ho tsitsisa mantle le ho thibela tšenyo ea mala.

Tšenyo ea mala kapa ho ruruha ho bakoa ke ulcerative colitis e ka lebisang kotsing ea mofets'e. Ts'ebeliso ea PEA e emisitse lisele tse tloaelehileng tsa mala ho khothaletsa ho eketseha ha mofets'e ho litoeba. PEA e fokotsa li-cytokine tsa ho ruruha le kholo ea li-neutrophil le lisele tsa 'mele tse matlafatsang matšoao a ts'enyo ea mala.

 

Mehloli ea lijo tsa Palmitoylethanolamide

Le ha PEA e le mafura a nang le mafura a mangata, ho kenyeletsoa mafura a mangata lijong tsa hau a tla ba kotsi ho feta molemo. Ho ja lijo tse nang le mafura a mangata ho ke ke ha eketsa tlhahiso ea 'mele oa' mele oa hau ho e-na le hoo ho tla eketsa menyetla ea ho ba le mafu a sa foleng a sa foleng.

Lijo tse kang lihlahisoa tsa soya, lecithin ea soya, makotomane le lesere ke mehloli e meng e meholo ea PEA. Batho ba nang le pheko ea linate ba tlameha ho tlola linate le ho ja lijo tse ling. Lehe la yolk ke mohloli o mong o motle mme le ka jeoa ke batho ba se nang kutloelo mahe. Bareki ba ka nahana ho nka li-supplements tsa PEA kaha ke khetho e sireletsehileng le e sebetsang.

 

PEA e eketsa litekanyetso le polokeho

Ho ea ka lithuto tsa bongaka, bonyane ho ka hlokahala 600 mg / letsatsi ho kokobetsa bohloko ba methapo, 'me tekanyetso ea 1.2 g / letsatsi e ka sebelisoa ho phekola bohloko ba methapo ea lefu la tsoekere.

Bakeng sa bakuli ba nang le lefu la tsoekere ba nang le mathata a mahlo, litekanyetso ho fihlela 1.8 g / letsatsi li ne li sebetsa ho fokotsa tšenyo ea methapo ea mahlo.

Bakeng sa pheko ea sefuba se tloaelehileng, 1.2 g / letsatsi la PEA e ne e le tekanyetso e tloaelehileng.

Bua le ngaka ea hau pele u nka li-PEA tse tlatsetsang kaha PEA ha e so amoheloe ke FDA ho nka litekanyo tse kholo.

Ho ja phofo ea Palmitoylethanolamide kapa li-supplements tse nyane, ka tekanyetso e lekanyelitsoeng hangata ho nkuoa ho bolokehile. Leha ho le joalo, ho hlokahala lithuto tse tsoetseng pele tsa bongaka bakeng sa litekanyetso tse phahameng. Tlatsetso ea PEA ea nako e telele e boetse e tsejoa e sireletsehile ho latela lithuto tse ling tse nyane.

Bahlahisi ba bang ba tsoang fekthering ea baetsi ba PEA ba khothaletsa ho arola palo e felletseng likarolo tse peli ebe ba e ja motšehare. Maemong a mang, PEA e nang le micronized, eo ka mantsoe a bonolo e leng phofo e ntle ea palmitoylethanolamide, e tsebahala hore e kenella hantle 'meleng mme bo-rasaense ba nka mofuta oa phofo o phahametse mefuta e meng.

 

Litla-morao tsa PEA

Ts'ebeliso ea molomo ea palmitoylethanolamide hangata e nkuoa e bolokehile ho batho ba baholo ha e sebelisoa ho fihlela likhoeli tse 3. Ho fihlela joale, ha ho mathata a tebileng kapa tšebelisano-'moho ea lithethefatsi le lithethefatsi e fumanoeng. Leha ho le joalo, ha ho na tlhaiso-leseling e lekaneng ea hore setlhare se ka bolokeha ha se sebelisoa nako e telele ho feta likhoeli tse tharo. Litla-morao li ka kenyelletsa mpa e halefileng, e leng ntho e sa tloaelehang haholo.

Ho hlaka haholoanyane, PEA ha ea ka ea baka mathata afe kapa afe a tebileng thutong efe kapa efe e kaholimo empa e ntse e hloka lithuto tse nepahetseng tsa polokeho. Hape, ha ho na bopaki bo lekaneng ba ho bona palo ea katleho ea PEA ho bakuli ba nang le mefuta ena ea bohloko.

 

Boimana le bana

Hangata PEA e nkuoa e bolokehile bakeng sa ts'ebeliso ea batho ba baholo mme lithuto tse 'maloa le tsona li bontšitse likotsi tse tlase ho bana. Empa lithuto tse kholo li tla hloka ho netefatsa polokeho ea PEA ho bana. Ka lebaka la khaello ea tlhaiso-leseling e lekaneng ea bongaka, basali ba baimana le ba anyesang ba khothalletsoa ho latela tlhokomeliso le ho bona ngaka pele ba nka litlatsetso tsa PEA.

 

fihlela qeto e

PEA e fokolitse litlamorao tse bohloko le bohloko ha e ntse e ntlafatsa boleng ba bophelo. Lithuto tsa eona li ts'ehetsa polokeho le ts'ebetso ea mafura a mafura mme li khothalletsoa hore li bolokehe ts'ebelisong ea bongaka ea PEA. Tlatsetso e sebetsa ka ho fetisisa bakeng sa compression syndromes ho kenyelletsa carpal tunnel syndrome le bohloko ba mahlaba. Tlatsetso ea PEA e boetse e bonolo ho e nka mme e ka tsamaisoa ka molomo.

Hopola ho buisana le ngaka pele u nka li-PEA tse tlatsetsang kaha litekanyetso tse phahameng tsa PEA li ka baka mathata. Le ha mathata a le bobebe haholo ebile a sa teba, PEA ha ea lokela ho sebelisoa e le sebaka sa kalafo e amoheloang ea bongaka. Leha ho le joalo, melemo le lithuto tse hlalositsoeng kaholimo li ne li etsoa haholo liphoofolong le liseleng. Bopaki bo tsitsitseng ba kliniki bo ntse bo haella.

Liphuputso tse ling ho batho li hlokahala ho tseba litlamorao tsa PEA ho bophelo bo botle ba pelo, pelo le histamine.

 

Palmitoylethanolamide (PEA) phofo e rekisoang le moo o ka rekang phofo ea Palmitoylethanolamide (PEA) ka bongata

Khamphani ea rona e thabela likamano tsa nako e telele le bareki ba rona hobane re tsepamisa maikutlo mosebetsing oa bareki le ho fana ka lihlahisoa tse ntle. Haeba o rata sehlahisoa sa rona, re feto-fetoha le maemo ka mokhoa oo re ratang ho odara ka oona o lekanang tlhoko ea hau le nako ea hau ea kapele ea li-odara e tiisa hore o tla latsoa sehlahisoa sa rona ka nako. Re shebile hape le lits'ebeletso tse kenyellelitsoeng boleng. Re fumaneha bakeng sa lipotso tsa ts'ebeletso le tlhaiso-leseling ho ts'ehetsa khoebo ea hau.

Re morekisi oa phofo ea Palmitoylethanolamide (PEA) ka lilemo tse ngata, re fana ka lihlahisoa ka theko ea tlholisano, 'me sehlahisoa sa rona ke sa boleng bo holimo ebile sea hlahlojoa ka thata, se ikemetseng ho netefatsa hore se bolokehile bakeng sa ts'ebeliso lefatšeng ka bophara.

 

References

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  • Petrosino S, Iuvone T, Di Marzo V. N-Palmitoyl-ethanolamine: biochemistry le menyetla e mecha ea phekolo. Biochimie. 2010; 92 (6): 724-7
  • Cerrato S, Brazis P, della Valle MF, Miolo A, Puigdemont A. Liphello tsa Palmitoylethanolamide ho histunised e kentsoeng histamine, PGD2 le TNFα ho lokolloa liseleng tsa 'mele oa "canine". Vet Immunol Immunopathol. 2010; 133 (1): 9–15
  • Palmitoylethanolamide (PEA): Melemo, Tekanyetso, Tšebeliso, Tlatsetso