7,8-Dihydroxyflavone (38183-03-8)

November 23, 2021

Cofttek ke moetsi ea molemo ka ho fetisisa oa 7,8-DIHYDROXYFLAVONE oa phofo Chaena. Feme ea rona e na le sistimi e felletseng ea taolo ea tlhahiso (ISO9001 & ISO14001), e nang le bokhoni ba khoeli le khoeli ba tlhahiso ea 260kg.


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 1kg / mokotla, 25kg / Drum

7,8-DIHYDROXYFLAVONE (38183-03-8) Slitšobotsi

Name: 7,8-DIHYDROXYFLAVONE
CAS: 38183-03-8
Ho hloeka 98%
Limolek'hule Mokgwa wa ho Nahana: C15H10O4
Boima ba limolek'hule: 254.238 g / mol
Melt Point: 250-252 ° C
Lebitso la k'hemik'hale Tropoflavin; 7,8-DHF
Li-synonyms: 7,8-dihydroxyflavone 38183-03-8 7,8-dihydroxy-2-phenyl-4H-chromen-4-one 7,8-Dihydroxyflavone hydrate 7,8-DHF
InChI Key: COCYGNDCWFKTMF-UHFFFAOYSA-N
Halofo ea bophelo: < metsotso e 30 (ka litoeba)
Solubility: 7,8-DHF e qhibiliha ka har'a metsoako ea tlhaho e kang ethanol, DMSO, le dimethyl formamide (DMF).
Boemo ba ho Boloka: 0 - 4 C bakeng sa nako e khuts'oane (matsatsi ho isa ho libeke), kapa -20 C nako e telele (likhoeli)
e sebetsa joang: 7,8-DHF ke flavonoid ea maiketsetso e ka fihlang bokong le ho kenya tšebetsong receptor (TrkB) e khothalletsang kholo ea neuronal. Bopaki bo bong ba liphoofolo bo fana ka maikutlo a hore 7,8-DHF e ka 'na ea e-ba le melemo e itseng ea kelello le motlakase' me e ka 'na ea e-ba nootropic.
Ponahalo: Phororo e mosehla

 

7,8-DIHYDROXYFLAVONE (38183-03-8) ke eng?

7,8-Dihydroxyflavone (7,8-DHF) ke flavone e fumanehang dimeleng. E ile ea sibolloa ha ho ntse ho batlisisoa limolek'hule tse etsisang tšebetso ea boko-derived neurotrophic factor (BDNF).

BDNF e khothalletsa kholo ea methapo ea kutlo le li-synaptogenesis (synaptogenesis) mme e bohlokoa haholo bakeng sa ts'ebetso e tloaelehileng ea boko. Palo e tlase ea BDNF e bonoa mafung a kang khatello ea maikutlo, Alzheimer's, Parkinson's, le schizophrenia.

Liphuputso tse entsoeng liphoofolong li bontša hore 7,8-DHF e ka thusa ho lokisa boko, ho hopola nako e telele, ho tepella maikutlong le mafu a amanang le neurodegenerative.

 

7,8-DIHYDROXYFLAVONE (38183-03-8) melemo e

Khopolo le ho ithuta

7,8-DHF e ntlafalitse temoho ea ntho (teko e sebelisetsoang ho fumana thuto le mohopolo) ho likhoto tse phetseng hantle ha li fanoa hang ka mor'a le lihora tse tharo ka mor'a ho ithuta. E boetse e ntlafalitse mohopolo ho litoeba tse nang le 'dementia'. Mehlala ea likhoto tsa post-traumatic stress disorder (PTSD), 7,8-DHF e ile ea thibela ho senyeha ha mohopolo ho amanang le khatello ea kelello. 7,8-DHF le eona e ntlafalitse mohopolo ho likhoto tse tsofetseng.

 

Ho lokisa Boko

7,8-DHF e khothalelitse tokiso ea methapo ea kutlo e senyehileng. E boetse e ekelitse tlhahiso ea li-neurone tse ncha bokong ba litoeba tsa batho ba baholo ka mor'a kotsi ea boko le ho khothaletsa kholo ea neuron ho litoeba tse tsofetseng. Ka mokhoa o ts'oanang, 7,8-DHF, hammoho le boikoetliso, e ntlafalitse ts'ebetso ea boko ho likhoto tse ileng tsa hlaheloa ke kotsi e bohloko ea boko.

 

Maloetse a Alzheimer

Mehlala ea liphoofolo bakeng sa lefu la Alzheimer, 7,8-DHF:

Ho fokotseha ha plaque ea amyloid

Khatello ea oxidative e fokotsehileng

Thibelo ea tahlehelo ea li-synapses

E thibetsoe ho haelloa ke mohopolo le ho boloka ts'ebetso ea kelello

Leha ho le joalo, thuto e 'ngoe ha ea ka ea fumana melemo ea ho phekola litoeba ka tšenyo ea boko e kang ea Alzheimer's ka 7,8-DHF.

 

Lefu la Parkinson

7,8-DHF e ntlafalitse ts'ebetso ea makoloi mme e thibela tahlehelo ea li-neurone tse amanang le dopamine ka mohlala oa toeba oa lefu la Parkinson.

E boetse e thibela lefu la dopamine-sensitive neurons mefuteng ea litšoene ea lefu la Parkinson.

 

7,8-DIHYDROXYFLAVONE (38183-03-8) sebelisa khanya?

7,8-Dihydroxyflavone (7,8-DHF) ke flavonoid ea tlhaho ea tlhaho. E bontšitse katleho khahlanong le mafu a 'maloa a tsamaiso ea methapo, ho kenyelletsa le Alzheimer's, Parkinson's, le Huntington's. 7,8-Dihydroxyflavone (7,8-DHF) ho nahanoa hore ke moemeli ea tšepisang oa phekolo bakeng sa mafu a fapaneng a neurodegenerative.

 

7,8-DIHYDROXYFLAVONE (38183-03-8) tekanyo

7,8-DHF e ka rekoa e le li-capsules/lipilisi, kapa phofo.

Ha ho tekanyo e sireletsehileng le e sebetsang ea 7,8-DHF hobane ha ho phuputso e lekaneng ea matla a lekaneng e entsoeng ho fumana e le 'ngoe. Tekanyo e atileng haholo ho li-supplement tse fumanehang khoebong ke 10 - 30 mg ka letsatsi.

 

7,8-DIHYDROXYFLAVONE phofo Ho rekisoa(Moo u ka Rekang phofo ea 7,8-DIHYDROXYFLAVONE ka bongata)

Khamphani ea rona e thabela likamano tsa nako e telele le bareki ba rona hobane re tsepamisa maikutlo mosebetsing oa bareki le ho fana ka lihlahisoa tse ntle. Haeba o rata sehlahisoa sa rona, re feto-fetoha le maemo ka mokhoa oo re ratang ho odara ka oona o lekanang tlhoko ea hau le nako ea hau ea kapele ea li-odara e tiisa hore o tla latsoa sehlahisoa sa rona ka nako. Re shebile hape le lits'ebeletso tse kenyellelitsoeng boleng. Re fumaneha bakeng sa lipotso tsa ts'ebeletso le tlhaiso-leseling ho ts'ehetsa khoebo ea hau.

Re setsebi sa 7,8-DIHYDROXYFLAVONE se fanang ka phofo ka lilemo tse 'maloa, re fana ka lihlahisoa ka theko ea tlhōlisano,' me sehlahisoa sa rona ke sa boleng bo phahameng ka ho fetisisa 'me se etsoa liteko tse thata, tse ikemetseng ho netefatsa hore li bolokehile hore li ka sebelisoa lefatšeng ka bophara.

 

References

  1. Schliebs R, Arendt T (2006) Bohlokoa ba tsamaiso ea cholinergic bokong nakong ea botsofali le lefung la Alzheimer. J Neural Transm (Vienna) 113: 1625-1644.
  2. Corbett A, Ballard C (2012) Liphekolo tse ncha le tse ntseng li hlaha tsa lefu la Alzheimer. Lithethefatsi Tse Hlahang tsa Setsebi 17:147–156.
  3. Giacobini E, Gold G (2013) Phekolo ea lefu la Alzheimer: Ho tloha ho amyloid-β ho ea tau. Nat Rev Neurol 9:677–686.
  4. Zuccato C, Cattaneo E (2009) Boko bo entsoeng ke neurotrophic factor ho mafu a neurodegenerative. Nat Rev Neurol 5:311–322.