Alpha-GPC (28319-77-9) Fektheri ea baetsi ba lihlahisoa

Alpha-GPC (28319-77-9)

April 7, 2020

Alpha GPC (alpha glycerophosphocholine), joalo ka citicoline, le eona e ka thusa tšebetso ea methapo. Ke motsoako o qapiloeng ke glycerophosphate le choline.

 


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 1kg / mokotla, 25kg / Drum

Video ea Alpha GPC (28319-77-9) video

 

Alpha GPC Slitšobotsi

 

Name: Alpha GPC
CAS: 28319-77-9
Ho hloeka 50% e seng phofo ea hygroscopic ; 50% & 99% phofo liquid 85% mokelikeli
Limolek'hule Mokgwa wa ho Nahana: C8H20NO6P
Boima ba limolek'hule: 257.223 g / mol
Melt Point: 142.5-143 ° C
Lebitso la k'hemik'hale Alpha GPC; Choline Alfoscerate; Alpha Glycerylphosphorylcholine
Li-synonyms: (R) -2,3-dihydroxypropyl (2- (trimethylammonio) ethyl) phosphate; sn-Glycero-3-phosphocholine
InChI Key: TLHOKOMELISO-MRVPVSSYSA-N
Halofo ea bophelo: dihora tse 4-6
Solubility: Soluble ho DMSO, Methanol, Metsi
Boemo ba ho Boloka: 0 - 4 C bakeng sa nako e khuts'oane (matsatsi ho isa ho libeke), kapa -20 C nako e telele (likhoeli)
e sebetsa joang: Alpha GPC (Choline Alfoscerate) ke phospholipid; moetapele oa choline biosynthesis le bohareng ba tsela ea "catabolic" phosphatidylcholine. Alpha GPC e sebelisoa e le Nootropic.
Ponahalo: Pula e tšoeu

 

Alpha GPC ke eng (28319-77-9)?

Alpha GPC (alpha glycerophosphocholine), joalo ka citicoline, le eona e ka thusa tšebetso ea methapo. Ke motsoako o qapiloeng ke glycerophosphate le choline. Alpha GPC ke motsoako oa tlhaho o ka sebelisanang hantle le li-nootropics tse ling. Alpha GPC e sebetsa ka potlako mme e thusa ho isa choline bokong mme ha e le hantle e eketsa tlhahiso ea acetylcholine hammoho le phospholipids ea cell membrane. Ho ka etsahala hore komiki e ka eketsa ho lokolloa ha dopamine le calcium.

 

Melemo ea Alpha GPC (28319-77-9)

Alpha GPC e tlisa melemo e mengata e ka bang teng, e 'ngoe ea bohlokoa ka ho fetisisa ke monyetla oa ho ntlafatsa bophelo bo botle ba kelello le kelello. Ho kanna ha khoneha bakeng sa Alpha GPC ho ntlafatsa mokhoa oa ho hopola le ho ntlafatsa bokhoni ba ho ithuta. Melemo ea ho ntlafatsa memori e tsoang ho alpha GPC e kanna ea khutlisa memori, empa maemong a itseng feela. Alpha GPC e ka boela ea phahamisa maemo a dopamine, e leng e thusang boko ba ts'ebetso haholo.

Alpha GPC ke phospholipid metabolite e qhibilihang ka metsi e sebetsang e le selelekela sa acetylcholine (ACh) le phosphatidylcholine (PC) biosynthesis ho pholletsa le 'mele. Ka lebaka la boemo ba eona ba tšebetso le bokhoni ba ho tšela tšitiso ea mali le bokong, e bonahala e le komporo e sebetsang ka ho fetisisa ea cholinergic, ha e bapisoa le choline le CDP-choline, 'me e mamelloa hantle. Patlisiso e fana ka maikutlo a hore alpha-GPC e ts'ehetsa likarolo tse ngata ka har'a CNS ho kenyelletsa: karabelo ea maikutlo, ho ts'ehetsa ho ithuta le ho hopola, mme e ka bapala karolo ea ho ba le maikutlo a phetseng hantle. Ka lebaka la phepelo ea glycerophosphate, alpha-GPC le eona e bonahala e ts'ehetsa sebopeho le ts'ebetso ea lisele tsa methapo le lisele tsa cellular, mme e ka bapala karolo ea ho ts'ehetsa ts'ebetso ea boko bo phetseng hantle nakong ea ho hlaphoheloa ha kotsi.

 

Alpha GPC (28319-77-9) Mechanism Of Ketso?

Alpha GPC e khothalletsa tsamaiso ea cholinergic e hlokomelang likarolo tsa kelello tse kang ho hopola le ho nahana ka hlooho. Ke mohloli o ratoang oa choline o sebetsang e le selelekela sa neurotransmitter acetylcholine.

Acetylcholine e fumaneha hohle bokong le mmeleng mme e ikarabella bakeng sa melaetsa e mengata ea lik'hemik'hale eo re e romellang le ho e amohela. Hape, ntho e ncha e tsebahala haholo ka ho ithuta, le ho ts'oaroa ke mesifa, ka hona e theha sehokelo sa boko. Alpha GPC e sebetsa ka potlako mme e thusa ho isa choline bokong mme ha e le hantle e eketsa tlhahiso ea acetylcholine. Ka ho fana ka boko ba hau le choline e ngata ho ka fetolela seo ho acetylcholine mme ea kenya letsoho litlamorao tse ngata. Haholo-holo, acetylcholine e sebelisoa ke hippocampus ho theha mehopolo.

Acetylcholine e sebetsa ka mekhoa e fapaneng ea ho ts'ehetsa mohopolo oa hau oa ts'ebetso. E ka boela ea ntlafatsa tsebo ea hau ea puo, bokhoni ba hau ba ho beha mabaka le ho sebelisa mabaka, hammoho le tsebo ea hau ea ho iqapela. Ho tšoanang ho bohlokoa hape molemong oa ho hopola, ho hokahanya, le ho sisinyeha. Maemo a neurotransmitter ena ka tlhaho ea tlhaho le lilemo. Ho etsa bonnete ba hore o na le lik'hemik'hale tse ngata tsa boko tse fumanehang ho fihlela litlhoko tsa ts'ebetso ea hau ea kelello, o hloka ho phahamisa maemo.

 

Alpha GPC (28319-77-9) Kopo

Alpha-GPC ke k'hemik'hale e ntšoang ha acid e mafura e fumanoang ka har'a soya le limela tse ling li senyeha. E sebelisoa e le moriana.

Europe alpha-GPC ke moriana o fanang ka litlhare bakeng sa kalafo ea lefu la Alzheimer's. E fumaneha ka mefuta e 'meli; e mong o nkuoa ka molomo, e mong a fanoa joalo ka thupa. United States alpha-GPC e fumaneha e le tlatsetso ea lijo, haholo lihlahisoa tse khothaletsoang ho ntlafatsa memori.

Lisebelisoa tse ling tsa alpha-GPC li kenyelletsa kalafo ea mefuta e fapaneng ea 'dementia', stroke, le "mini-stroke" (tlhaselo e potlakileng ea ischemic, TIA). Alpha-GPC e boetse e sebelisetsoa ho ntlafatsa mohopolo, tsebo ea ho nahana le ho ithuta.

 

Alpha GPC phofo Ho rekisoa(U ka reka phofo ea Alpha GPC kae ka bongata)

Khamphani ea rona e thabela likamano tsa nako e telele le bareki ba rona hobane re tsepamisa maikutlo mosebetsing oa bareki le ho fana ka lihlahisoa tse ntle. Haeba o rata sehlahisoa sa rona, re feto-fetoha le maemo ka mokhoa oo re ratang ho odara ka oona o lekanang tlhoko ea hau le nako ea hau ea kapele ea li-odara e tiisa hore o tla latsoa sehlahisoa sa rona ka nako. Re shebile hape le lits'ebeletso tse kenyellelitsoeng boleng. Re fumaneha bakeng sa lipotso tsa ts'ebeletso le tlhaiso-leseling ho ts'ehetsa khoebo ea hau.

Re morekisi oa phofo ea Alfa GPC ea profesheneng ka lilemo tse ngata, re fana ka lihlahisoa ka theko ea tlholisano, 'me sehlahisoa sa rona ke sa boleng bo holimo haholo ebile se etsoa tlhahlobo e thata, e ikemetseng ho netefatsa hore e bolokehile bakeng sa ts'ebeliso lefatšeng ka bophara.

 

References

  • Ricci A, Bronzetti E, Vega JA, Amenta F. Oral choline alfoscerate e sebetsana le tahlehelo ea lilemo-lemo ea tahlehelo ea mossy ho hippocampus ea rat. Mech Aging Dev. 1992; 66 (1): 81-91. PubMed PMID: 1340517.
  • Amenta F, Ferrante F, Vega JA, Zaccheo D. Nako e telele ea kalafo ea alfoscerate ea kalafo e lekanya liphetoho tse tlisoang ke lilemo tsa liphetoho tsa bongoaneng tsa rat. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Sep; 18 (5): 915-24. PubMed PMID: 7972861.
  • Amenta F, Del Valle M, Vega JA, Zaccheo D. Liphetoho tsa sebopeho tse amanang le Age ho cortex ea rat cerear: phello ea kalafo ea alfoscerate ea choline. Mech Aging Dev. 1991 Dec 2; 61 (2): 173-86. PubMed PMID: 1824122.