Adelmidrol (1675-66-7) Moetsi - Cofttek

Adelmidrol (1675-66-7)

June 29, 2022

Cofttek ke moetsi ea molemo ka ho fetisisa oa Adelmidrol (1675-66-7) Chaena. Feme ea rona e na le sistimi e felletseng ea taolo ea tlhahiso (ISO9001 & ISO14001), e nang le bokhoni ba khoeli le khoeli ba tlhahiso ea 260kg.


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 1kg / mokotla, 25kg / Drum

Adelmidrol Slitšobotsi

Name: Adelmidrol
CAS: 1675-66-7
Ho hloeka 98%
Limolek'hule Mokgwa wa ho Nahana: C13H26N2O4
Boima ba limolek'hule: 274.36 g / mol
Qhibiliha Point: 132-134 ºC
Lebitso la k'hemik'hale N,N′-Bis(2-hydroxyethyl)nonanediamide
Li-synonyms: Adelmidrol 1675-66-7 N,N'-bis(2-hydroxyethyl)nonanediamide AdelMitrol UNII-1BUC3685QU More…
InChI Key: PAHZPHDAJQIETD-UHFFFAOYSA-N
Halofo ea bophelo: N / A
Solubility: E qhibilihang ka metsing; Ethanol; DMSO
Boemo ba ho Boloka: 0 - 4 C bakeng sa nako e khuts'oane (matsatsi ho isa ho libeke), kapa -20 C nako e telele (likhoeli)
e sebetsa joang: E sebelisoa haholo Italy meriana ea bongaka ba liphoofolo ho phekola ho ruruha ha letlalo. Ka 2015, ho ile ha fumanoa hore motsoako o boetse o na le khato e khahlanong le ho ruruha e fanoang ka mokhoa oa 10 mg ka boima ba 'mele.
Ponahalo: Pula e tšoeu

 

Adelmidrol (1675-66-7) ke eng?

Adelmidrol ke semisynthetic diethanolamide e nkiloeng ho azelaic acid, 'me e na le sebopeho sa lik'hemik'hale tse lekanang. E khethiloe e le amide, 'me e tšoana le palmitoylethanolamide, molek'hule ea motsoali sehlopheng sa lithethefatsi sa ALIAmide. ALIAmides ke sehlopha sa lintho tse nkiloeng ka mafura a acid tse nang le thepa ea cannabimimetic tse nang le litlamorao tse thibelang ho ruruha le li-analgesic mme ho nahanoa hore li sebetsa ka ho fokotsa tšebetso ea mast cell. Adelmidrol ke sehlahisoa sa ethanolamide se thibelang ho ruruha ho tsoa ho azelaic acid.

 

Adelmidrol (1675-66-7) melemo

Adelmidrol ke motsoako oa maiketsetso oa azelaic acid, e leng "dicarboxylic acid" e fumanehang ka tlhaho, e fumanoang lijo-thollong tse ling le ka bongata 'meleng oa motho. Ka lik'hemik'hale, ademidrol ke N,N-bis (2-hydroxyethyl) e seng anediamide 'me ke motsoako oa amphiphilic kapa amphipathic, o nang le thepa ea hydrophilic le hydrophobic, e ratang ho qhibiliha ha eona mecheng ea metsi le ea tlhaho. Adelmidrol ke ea lelapa la aliamide, sehlopha sa lihlahisoa tsa acid e mafura tse nang le thepa ea cannabimimetic, e khonang ho laola mast cell (MC) hyperreactivity maemong a 'maloa a pathophysiological le pathological. Pro-inflammatory NF-κB tsela e ile ea fokotseha ka mokhoa o hlakileng ka phekolo ea adelmidrol. Phello e khahlanong le ho ruruha ea adelmidrol e ne e bonahala e amana le ts'ebetso ea PPAR-gamma. Adelmidrol e sebetsa hantle bakeng sa mathata a letlalo a motho mme e khona ho fetola karabelo ea ho ruruha ho li-keratinocyte tsa batho. Motsoako oa hyaluronic acid le adelmidrol o ntlafatsa matšoao a osteoarthritis a bakoang ke monosodium iodoacetate.

 

Adelmidrol (1675-66-7) kopo?

Adelmidrol ke semisynthetic derivative ea azelaic acid le analogue ea anti-inflammatory compound palmitoylethanolamide (PEA), e leng aliamide le setho sa lelapa la mafura a acid amide a bontšang limolek'hule tse nang le thepa ea cannabimimetic. Liphello tse khahlanong le ho ruruha le li-antinociceptive tsa aliamides PEA le adelmidrol li bontšitsoe lithutong tse ngata tsa pele ho kliniki, ka bobeli le ka vivo. Liketso tsa bona ho nahanoa hore li bakoa, bonyane ka karolo e 'ngoe, ke bokhoni ba bona ba ho theola-modulate mast cell activation le mast cell mediator release maemong a pathophysiological le pathological.

 

Adelmidrol phofo Ho rekisoa(Moo u ka Rekang phofo ea Adelmidrol ka bongata)

Khamphani ea rona e thabela likamano tsa nako e telele le bareki ba rona hobane re tsepamisa maikutlo mosebetsing oa bareki le ho fana ka lihlahisoa tse ntle. Haeba o rata sehlahisoa sa rona, re feto-fetoha le maemo ka mokhoa oo re ratang ho odara ka oona o lekanang tlhoko ea hau le nako ea hau ea kapele ea li-odara e tiisa hore o tla latsoa sehlahisoa sa rona ka nako. Re shebile hape le lits'ebeletso tse kenyellelitsoeng boleng. Re fumaneha bakeng sa lipotso tsa ts'ebeletso le tlhaiso-leseling ho ts'ehetsa khoebo ea hau.

Re barekisi ba phofo ea Adelmidrol ea profeshenale ka lilemo tse 'maloa, re fana ka lihlahisoa ka theko ea tlholisano,' me sehlahisoa sa rona ke sa boleng bo holimo 'me se etsa liteko tse thata, tse ikemetseng ho netefatsa hore li bolokehile hore li ka sebelisoa lefatšeng ka bophara.

 

References

  1. Cerrato, Santiago; Brazis, Pilar; della Valle, Maria Federica; Miolo, Alda; Puigdemont, Anna (2012). "Phello e thibelang ea topical Adelmidrol holim'a letlalo le bakoang ke antigen le boitšoaro ba lisele tsa mast ka mohlala oa canine oa allergic dermatitis". Lipatlisiso tsa bongaka ba liphoofolo tsa BMC. 8 (1): 230. doi:10.1186/1746-6148-8-230. PMC 3540011. PMID 23181761.
  2. Cordaro, M; Impellizzeri, D; Gugliandolo, E; Siracusa, R; Crupi, R; Esposito, E; Cuzzocrea, S (2016). "Adelmidrol, Analogue ea Palmitoylethanolamide, e le Phekolo e Ncha ea Pharmacological bakeng sa Tsamaiso ea Mafu a Tšoaetso". Limolek'hule Pharmacology. 90 (5): 549–561. doi:10.1124/mol.116.105668. PMID 27625036.
  3. Abramo, F; Salluzzi, D; Leotta, R; Auxilia, S; Noli, C; Miolo, A; Mantis, P; Lloyd, D. H (2008). "Mast cell morphometry le densitometry ka maqeba a letlalo a liteko a tšoaroang ka gel e nang le adelmidrol: Thuto e laoloang ke placebo". Maqeba : A Compendium of Clinical Research and Practice. 20 (6): 149–57. PMID 25942520.

 


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