Coluracetam (135463-81-9)

E se eka 8, 2021

Cofttek ke moetsi o motle ka ho fetisisa oa phofo ea Coluracetam Chaena. Fektheri ea rona e na le sistimi e felletseng ea taolo ea tlhahiso (ISO9001 & ISO14001), e nang le tlhahiso ea khoeli le khoeli ea 160kg.

 


Boemo: Ka Phatlalatso ea Mesebetsi
Sehlopha: 1kg / mokotla, 25kg / Drum

Coluracetam (135463-81-9) Slitšobotsi

Name: Coluracetam
CAS: 135463-81-9
Ho hloeka 98%
Limolek'hule Mokgwa wa ho Nahana: C19H23N3O3
Boima ba limolek'hule: 341.411 g / moll
Melt Point: N / A
Lebitso la k'hemik'hale N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide

EA-231-MK

EA-540

Li-synonyms: Coluracetam; BCI-540; EA-231-MK EA-540-BC. EA-231-MK BCI540; MKC231.
InChI Key: PSPGQHXMUKWNDI-UHFFFAOYSA-N
Halofo ea bophelo: N / A
Solubility: Ho qhibiliha ho DMSO
Boemo ba ho Boloka: E omme, e lefifi ebile e le 0 - 4 C ka nako e khuts'oane (matsatsi ho isa ho libeke) kapa -20 C nako e telele (likhoeli ho isa ho lilemo)
e sebetsa joang: Phororo ea Raw Coluracetam (MKC-231) ke lithethefatsi tse entsoeng ka racetam tse nkoang e le methapo ea nootropic.
Ponahalo: phofo e tšoeu ea kristale

 

Coluracetam (135463-81-9) NMR Spectrum

Coluracetam (135463-81-9) NMR Spectrum

Haeba o hloka COA, MSDS, HNMR bakeng sa sehlopha ka seng sa sehlahisoa le tlhaiso-leseling e ngoe, ka kopo ikopanye le rona mookameli oa papatso.

 

ke eng Coluracetam (135463-81-9)?

Phororo ea Raw Coluracetam (MKC-231) ke lithethefatsi tse entsoeng ka racetam tse nkoang e le methapo ea nootropic. Ha e na bopaki bo bongata ba lipatlisiso, empa mekhoa ea liketso (hammoho le moralo) e bonahala e fapane haholo le metsoako e meng ea racetam e kang Piracetam kapa Aniracetam.

Mokelikeli oa Raw Coluracetam o bonahala o sebelisana le ts'ebetso e tsejoang e le ho ba le kamano e phahameng ea coline (HACU ka nako e khuts'oanyane), e leng mohato o lekanyelitsoeng oa ho taka o kene ka neuron bakeng sa ho kenngoa ka neurotransmitter acetylcholine. Ho eketsa lebelo la HACU ho bonahala ho eketsa ts'ebetso ea li-neurons tsa cholinergic, kahoo ke sepheo se lakatsehang sa ho ntlafatsa tsebo.

 

Coluracetam (135463-81-9) melemo e

  • Ntlafatsa Memori le Ho Ithuta
  • Ntlafatsa Ho Utloisisa ho Bala le ho Hopola Mahala
  • Ntlafatso ea Kelello ea nako e telele
  • Fokotsa Phekolo e Loantšang ho Tepella Maikutlo
  • Khothatso e ka bang teng ea Neurogeneis
  • E ka ntlafatsa Ho holofala kelellong
  • E kanna ea Ntlafatsa Pono
  • Ntlafatso ea matšoao a Bowel Syndrome
  • Tšebeliso ea boithabiso ba Coluracetam

 

Coluracetam (135463-81-9) sebelisa khanya

Coluracetam (INN) (lebitso la khoutu BCI-540; eo pele e neng e le MKC-231) phofo ke moemeli oa nootropic oa lelapa la racetam. Qalong e ile ea ntlafatsoa le ho lekoa ke Mitsubishi Tanabe Pharma Corporation bakeng sa lefu la Alzheimer's. Kamora hore sethethefatsi se hlolehe ho fihlela lintlafatso litekong tsa sona tsa bongaka se ile sa fuoa laesense ke BrainCells Inc bakeng sa lipatlisiso mabapi le lefu le leholo la khatello ea maikutlo (MDD), le neng le etelletsoe pele ke ho fuoa "Grantifying Therapeutic Discovery Program Grant" ke naha ea California.

 

Coluracetam (135463-81-9) Tekanyo

Boholo ba lipatlisiso ka coluracetam e ne e etsoa liphoofolong ho e-na le batho, kahoo ha ho na tataiso e amohelehang ea litekanyetso. Mofuta o lekaneng oa tekanyo ea tekanyetso e hlalosoa e le 5-20 mg. Basebedisi ba coluracetam ba tlalehile litekanyetso tse fapaneng tsa litekanyetso tse tsamaisoang ka molomo le ka mokhoa o sa tšoaneng.

Maikutlo a basebelisi a boetse a boletse hore mamello ea phofo ea coluracetam e ka hlaha kapele. Joalo ka meriana eohle, haholo-holo li-nootropics, ho molemo ho qala ka litekanyetso tse nyane mme o nyolohe lethal dose hanyane ka hanyane ha mmele oa hau o sebetsana le ho fetohela ho meriana. Coluracetam ha e na chefo ebile e nkuoa e mamelloa hantle ebile e bolokehile.

 

Coluracetam powder Ho rekisoa(Moo u ka rekang phofo ea Coluracetam ka bongata)

Khamphani ea rona e thabela likamano tsa nako e telele le bareki ba rona hobane re tsepamisa maikutlo mosebetsing oa bareki le ho fana ka lihlahisoa tse ntle. Haeba o rata sehlahisoa sa rona, re feto-fetoha le maemo ka mokhoa oo re ratang ho odara ka oona o lekanang tlhoko ea hau le nako ea hau ea kapele ea li-odara e tiisa hore o tla latsoa sehlahisoa sa rona ka nako. Re shebile hape le lits'ebeletso tse kenyellelitsoeng boleng. Re fumaneha bakeng sa lipotso tsa ts'ebeletso le tlhaiso-leseling ho ts'ehetsa khoebo ea hau.

Re mofani oa litsebi oa phofo ea Coluracetam ka lilemo tse 'maloa, re fana ka lihlahisoa ka theko ea tlholisano,' me sehlahisoa sa rona ke sa boleng bo holimo haholo 'me se etsoa liteko tse thata, tse ikemetseng ho netefatsa hore se bolokehile hore se ka sebelisoa lefatšeng ka bophara.

 

References

[1] Akaike A, et al. (1998). Tšireletso ea MKC-231, bukana e phahameng ea kamano e matla ea choline e matlafatsang, ho glutamate cytotoxicity ho li-cortical neurons tse tsoetseng pele. Jpn J Pharmacol.

[2] Bessho, T., Takashina, K., Tabata, R., Ohshima, C., Chaki, H., Yamabe, H., Egawa, M., Tobe, A., & Saito, K. (1996). Phello ea bukana e phahameng ea kamano e amanang le choline e ntlafatsang 2- (2-oxopyrrolidin-1-yl) -N- (2,3-dimethyl-5,6,7,8-tetrahydrofuro [2,3-b] quinolin-4- yl) acetoamide ka khaello ea methati ea metsi e ithutang ka likhoto. Arzneimittel-Forschung, 46 (4), 369-373.

[3] Murai, S., Saito, H., Abe, E., Masuda, Y., Odashima, J., & Itoh, T. (1994). MKC-231, e ntlafatsang choline, e ntlafatsa likhaello tsa mohopolo le ho fokotsa hippocampal acetylcholine e susumetsoang ke ethylcholine aziridinium ion ho litoeba. Leqephe la Phatlalatso ea Neural Transmission, 98 (1), 1-13 / bf10.1007.

[4] Takashina K, Bessho T, Mori R, Eguchi J, Saito K. MKC-231, ntlafatso e ntlafatsang ea choline: (2) Kameho ea ho qala le ho lokolloa ha acetylcholine ho likhoto tse tšoeroeng ke AF64A. J Neural Transm (Vienna). 2008 Jul; 115 (7): 1027-35. Doi: 10.1007 / s00702-008-0048-1. PubMed PMID: 18446264.

[5] Shirayama Y, Yamamoto A, Nishimura T, Katayama S, Kawahara R. Ho pepeseha hoa ts'ebetso ea choline e ntlafatsang MKC-231 ho hlekefetsa boitšoaro ba phencyclidine bo bakiloeng ke boitšoaro le phokotso ea li-neurons tsa septal cholinergic ho litoeba. Eur Neuropsychopharmacol. 2007 Sep; 17 (9): 616-26. PubMed PMID: 17467960.